昭衍新药2024年度报告

（於中華人民共和國註冊成立的股份有限公司）股份代號：6127 2024年度報告 27810111235417195102104106108111 H 1617 202412 2020251 2320251 23202410 30 20251 2320251 2320251 2320251 2320251 2320251 23 20251 2320251 2320251 2320251 23 5100176 20251 2320251 2320251 2320251 23202412 20 33191920 20251 2320251 2320251 2320251 23 5100176 15323203-3207 20251 2320251 23202412 2020251 23 35A509100033 H6127A603127 108https://www.joinnlabs.com 2024 20.185,018.6822 2025 20253 28 1. 20242218.42024 (1)(2)GLP-1PROTAC(CNS)ADC(3)CGTiPSCmRNA(4)(5)20243.8 2024 (i) (1) 2024FDA GLPFDA3GLP5FDA GLPGLP NMPAFDAOECDMFDSPMDAGLP (2) AMD GLP-1GCGHPVPBMC GLP-1R/GCGR/GIPRGLP-1RGCGR GIPR MSDADCPEGELISAqPCRELISPOT WB FLOWmRNAsiRNAPCRmRNA ADCPROTAC (3) BADC 300-500mgProtein A BPCR10X genomics B (ADC)INDADCADCADC 20242024 (ii) IIIT ADCPROTAC (IHC)(MIF)LC-MS/MSPCR20241120251 (iii) (1) 2024allo-HSCTGvHD (2) (Nano-antibody)(ZL 2023 1 1309170.3)HINI (Homology Independent and Navigated Insertion) (3) 2024CiPSCsiPSCs iPSC (iv) 12CNASGLP 202412 31CHO/3T3NK2022CDEFDA 20242024202412312,652 II20,00022,0002025 2024 2. 202412 312,018.3202312 312,376.515.1% 202412 311,512.8202312 311,397.18.3%202412 31 202412 31505.525.0%202312 31979.441.2%202412 31 202412 31161.2202312 31240.533.0% 202412 31103.2202312 31142.527.6% 4.12023123143.2109.5% 202412 31122.9202312 31288.8 202412 3127.9202312 3124.613.3% 202412 31315.920231231296.56.6%202412 31 202412 3192.9202312 3196.94.1%202412 31 202412 312.4202312 313.122.1% 202412 3134.3202312 31115.470.3% 202412 3133%202312 3122.8% 202312 31391.682.2%2024123169.8202312 3116.5%202412313.5% 202412 31 202412 3120,000 202412 313580,000 •••••17• ••••• 202412 31 202412 31965.2202312 312,862.966.3% 202412 3114.0%202312 3117.4% 202412 31 202412 31 202412 31 3. CROCROCRO CRO CROCRO CROCRO CROCRO 1. (1)2025GLP (2) (3)PCC;FDA/EMAADMEPK-PDLC-MS/MSPDPKAI (4)GLP (5)2025 2. GLPGCP (1)(2)(3)(4) 3. (1) (2)2025 (3) 4. 1. 2. 3. 4. CRO 5. 6. 7. 61199582007620208 1995820076 19868198982521992199420192 1986719928 4320121120131020208201912013320208 2012112013120131202032019720203 200582006720076201210300204 20057 571999102019120208201212 1999102005420054200862008720091220101 201110201810201911 19957 4820077201242012520153201532021920219202311202312 4520064 20187201712021102017120214 20066 602025119877199212199212199561995620001220001220046(NIH)(NHLBI)20067820046200510201510201710202310 55202511993619999201191993719999200051120012200732007420098200992015120151202012202122023520239 552025120245202020057201082005720104202311200742008520091020198201022014820244201532015820226201882018620247300901.SZ 4620212 20012006201020182018201920192024420245 2001620105(Carnegie MellonUniversity) 50202211 IPMPC200142005420055200772007820217202182023120232 43202211 200662007420191 41202211 20062006200720081201072010820228 43 57 45 4920197201972020320204 20002200232005720081220086201212012220194 2005720109(ICAEW) 20241231202412 316225 1995 102103 202412 31202420240.0320230.1620253 28749,477,3343,303,034A20242024746,174,30022,385,2292023119,977,000 202412 31202412 314 202420258 31 2024 AH 10 H10%HH 12 622 H II. 202412 31822.2 20242 2720242024A2024H2021A 202412 31 B882377509411,365AA42.37A20247 11 202412 3113.91C2 2024328A0.51A2024A2,656,10042,658,273.40 34(d) 16616734(a) H6,174,000H55,734,805.00 202412 31H2,689,314A H20212 2620213 1940,800H20213 24H151.006,373.65,285.2 20224 2820238 30202412 20 202412 312,747.2 9 13.51B(1) 3540 3.25C1 14014289 202412 31202412 31 202412 31 202412 31 202412 31 13.2013.21 13.22 A201720178 25 202412 31 (i) (ii) (iii) 202412 31 (d) 5% 201820192020 (e) A (a) (f) 1%10% (b) 2020 (g) (c) 48 201820192020 20192020(i)50%1224(ii)50%2436 (h) 60 (i) (j) 122436 2019(i)50%1224(ii)30%2436(iii)20%3648 48 (k) (1) (i)1A11(ii)20A20A20A (2) (i)1A1150%(ii)20A20A20A50% (3) (4) (6) (7) (m) (8) (1)(2)(3)(4)A(5)AAA (9) (10) 20241 1202412 31202412 31A (1)20241 12020818,888(2)202412 312020(3)20241 12020818,8880.1%20182019(4)20248 302020818,888A2020 (b) 2022HH 20221 19202211 182021A2021A2022A (c) 20241 1202412 312021A2021A2022AA2021A2021A2022A (d) 2022HH 2022H 20226 242022H (e) (a) 2022H600H 2022H(i)(ii)(iii) H (g) 2022H2022H2022624102022H7 2022H (h)H (f) 2022HH 2022H 2022H 2022HH6,174,000H55,734,8050.82% (i)(ii)(iii) 202412 31XV352C3 (1)A167,160,633A202412 3122.30%A74,725,981A202412 319.97%A2,689,314A202412 310.36%244,575,928202412 3132.63%A (2)L (3)20241231749,477,334630,482,128A2,689,314118,995,206HA XVXV78352 202412 31XV233365% (1)L(2)20241231749,477,334630,482,128A2,689,314118,995,206HA(3)(1) 202412 31XV233365% 20241231852 • • 202412 312,6522019Biomere 5% 10%10%10%(1)10%(2)10%20%(3)20% 2.87%11.76% 20068 21[2006]88410%25%5% 9.46%30.39% 5% H [1993]045[2011]348 HH12 20081110% 200811 6H[2008]897H200810% 202412 312,6522,6522,43