维亚生物2024年度报告

年度報告 247102641496789959697100102105233 Chartered Governance Institute 97927 榮 榮 榮 PO Box 309Ugland HouseGrand Cayman, KY1-1104Cayman Islands Chartered Governance Institute 735 33191901 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 1617 1873 www.vivabiotech.com CROCROBDAICDMOCDMOCMC •1,986.7687.4222.099.8314.650.6%CRO •72.9% •17,6811121,5681,867 •CROAIFICNew targetNovel MOANewModalityAIAIAI •CDMOCMCCDMOPPQ400CMC •22741936162.53 • (SBDD)CROCDMO 維 亞 生 物 主 1,986.72,155.67.8%687.4738.56.9%222.099.8 314.6208.8 i. CROCROCROCDMO 2,4652,155.61,986.77.8%738.5687.46.9%222.099.8208.8314.650.6%CRO 72.9% CRO CRO844.9810.94.0%363.8357.11.9%CROCROCROCROCRO 82,71617,6812,098112BDBDAI AIFICNew targetNovel MOANew ModalityAIAIAICRO1,56824.4%CRO87.3%3.9%12.7%5.1% 1,86713AIDD157CADD/AIDD51AIAI CDMO CDMOCMC 1,175.710.3%344.511.4%FDACDMO 89761.1%100%CDMOPPQCDMO860400WHOFDACDMO CMC CMCBDCMC255CMC105CMC43.0CMCBDCMCCMCBD74.0%26.0%CMCBD38.0%62.0%CMCBD Focus-X, Saverna, Dogma, Riparian, DTXNerio162.59367.7%25.8% 11292.722718641153 HayaMediar Nerio Full-LifeAbsciDogma Arthrosi Basking CybrexaFuseBio SBDDStructure-based Drug DiscoverySBDD(AI)SBDDNew TargetNovel MOANew ModalityAISBDD 2,098112PDBmRNA CROBioassay GPCRIonChannel ProteinsTransport Proteins Cryo-EM Single Particle Analysis, SPAXX-ray crystallography XRDNuclear Magnetic Resonance,NMR V-DELDNADNAGPCRASMS, SPRIntactbioassayASMSSPRHDX-MSX XDCXDCXDCXDCXDCDNA(DEL)DEL(AOC)XDCXDC AIAIDELAIPKPDCRDCCEM Liberty Blue 2.0H12APC PROTACCRO10.75%PROTACBioassayCADD/AIDDE350PROTAC150PROTACCRO AISBDDComputer-aided Drug Discovery, CADDArtificial Intelligence Drug Discovery, AIDD(modality)AIDDADME/PKPROTACRNACADDAIDD AIAIAIAIAI AISBDDCRO 2,063CRO1,121711 •40,000•7,5765,552•64,56412,21010,800•7,5455,305•6,3625,335•(CADD)(AIDD)•35,1682,5001,3001,500 (SBDD)CROCDMO 1,986.72,155.67.8%(1)(2)FDA(3)CDMO 1,299.31,417.18.3% 687.4738.56.9%34.6%34.3% 81.787.16.1% 112.2132.515.3% 251.9277.19.1% 88.0128.031.2% EFS5% 83.7Dogma Therapeutics, Inc.Mediar Therapeutics, Inc.Nerio Therapeutics,Inc.11.7 5.68.1 45.4321.7 53.9176.669.5% 174.3 73.743.868.2% 222.099.8 314.6208.8CRO 941.61,036.39.1%616.2 1,876.6941.61,126.7549.4948.2 45.9%50.5%866.4388.91,871.5616.2549.4705.9 196.1191.00.1827.7 134.3158.9 5% 16.251.0 2,156.42,156.4 Synthesis HKCDMOCROCDMOBD 榮 4148 1 6225 • CRO/CMO • • • EFSEFS • (i)(ii)(iii)(iv)(v)(vi) ISO 14001(PSCI)ES 2.4 30,016,0000.75% 40 14A 14A.71 33.8%28.1%26.8%19.6% 25.0%21.5%10.7%10.1% 5% 7 1 14 35 280 BVIJ.P. Morgan Securities plcBVI2801.00%100%11.6370(i)8.6235.0%(ii)8.3539.4%28011.6370186,519,8934.227.5275.81,801.6Viva Biotech Investment250,000,000256,521,0001,785,937,000 36 95232 1001012323,874.23,874.2 32 28,604,50025.1 (1) 28,604,500 BVI 1641681011 19920836 1617 63CRO28BVI ••ZRG1AARR-1 (50)•Medicilon Inc. 45 62CRO16Viva ManagementVivaGT 65CROCRO15 • • 10 53Fenghe Fund Management Pte. Ltd. 512190 62Pharmacyclics, Inc. 榮52HK.3389HMIN(600258)MakeMyTrip LimitedMMYT6686NOAH 62 65MRK14 41 4510Scientific Leader & GSK FellowFrank and Sara McKnight FellowHelen Hay Whitney Fellow·50Faculty OpinionsSAPA-GP 52EHSNYSEBABACDN 38 50Vistra Corporate Services (HK) LimitedVistraVistra 24Chartered Governance Institute 13.2013.21 13.22 C.2.1 ••• 榮 41483.09D C.2.1 C.5.1 C.5.1 3.13 3.21C.4D.3榮榮榮3.10(2)3.21 54 •••• 3.25E.1榮榮E.1.2(c)17 54 10 B.3榮 54 50596069 4346 0.55:0.45 40% A.2.1 C.1.4 C.1.1 榮 8994 (1)(2)(3) • • • • • • Vistra Corporate Services(HK)Limited 3.2915 12.3 212150% 735201318+86 21 60893288+86 21 58243936info@vivabiotech.com www.vivabiotech.com XV(a)XV78(b)352(c) (i) (1)L(2)Min Zhou 2018 Family TrustMZFT, LLCMZFT, LLCMin Zhou 2018 Family TrustThe Chen Mao Charitable Remainder TrustZhou MinZhou Min維 亞 生 物 科 技 控 股 集 團(3)維 亞 生 物 科 技 控 股 集 團(4)維 亞 生 物 科 技 控 股 集 團(5)HLC VGC Partners HK II LimitedHLC SPV85,000,000HLC SPVVGC Fund IV L.P.HLC VGC GP IV Limited+ (ii) (1)(2)Chencheney Ltd.100.0%Chencheney Ltd.Anji PharmaceuticalsClues Therapeutics(3)Chencheney LtdClues Therapeutics Inc.447,039.0928%(4)(5)(6)5 XVXV78352 XV23336 (2)(3)Fenghe Harvest Ltd(3)JPMorgan Chase & Co.(4) 1.LS2.Mao and Sons LimitedZhang and Sons Limited JL and JSW Holding LimitedTIANL Holding Limited131,057,6543.Fenghe Harvest LtdWu and Sons Limited100.00%FengheHarvest LtdWu and Sons Limited4.29,500(S)5.Huangshan Investments Pte. Ltd.True Light Investments H Pte. Ltd.Tamasek HoldingsPrivate Limited+ XV23336 1. (a) (i)270,937,30257,892,3512,194,55522.07% (ii) (iii) (iv)(i)422(ii)(a)(b) (v) (vi)(i)(a)10%110%(b)100%(ii)85%(iii) (vii) (viii) (ix) (1)40%20%20%20% 2. 1 i.0.1% ii.5(i)(ii)(iii) i.ii.iii. 10%150,000,000 10% 30%30% 121% 121% (1)(i)40%(ii)30%(iii)30% 60%90%120%9.70 (2)(i)60%(ii)40%270%360%5.46 (3)(i)60%(ii)40% 90%2.89 36111,235,000118,085,00019,960,0000.94