维亚生物2023年度报告

247102643506891979899101103105233 (Chartered Governance Institute) 97927 榮 榮 榮 PO Box 309Ugland HouseGrand Cayman, KY1-1104Cayman Islands (Chartered Governance Institute) 735 33191901 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 1617 1873 www.vivabiotech.com 2.25CROBDCDMOCDMO •2,155.6738.599.8504.2208.8 •2.25•16,11081,3982,059 •CROPROTACBioassay(CADD)(AIDD)V-DELXDC •CMCCDMOCMCCMC155183860400 •2223761-37 • BDCROCDMO 維 亞 生 物 主 2,155.62,379.69.4%738.5815.79.5%99.8504.2 208.8133.9 i. a)b) CROCDMO 2,2782,379.62,155.69.4%815.7738.59.5%99.8504.2133.9208.8 2.25 CRO CRO895.1844.95.6%397.3363.78.5%EFSCRO 65,03516,1101,8868BDBDCROV-DELXDCCRO1,39825.7%CRO87.1%3.7%12.9%16.6% 2,05913 CDMOCMC CDMOCMC 1,310.711.7%388.810.1%CDMO 88051.2%100%CROCMCCDMO8604002024 CMCCMC183CMC113CMC56.7CMCBDCMCCMCBD63.0%37.0%CMCBD31.0%69.0%CMCBD 619267.0%26.0% 12236.022218537131-37 DogmaArthrosi BaskingTriumviraDeka Mediar Cybrexa 14 CROPROTACBioassay(CADD)(AIDD)V-DELXDC V-DELDNADEL PDCRDCV-DEL XDC (CADD)(AIDD)FEPRNACADDAIDD Cryo-EM Single Particle Analysis, SPAXX-ray crystallography XRDNuclear Magnetic Resonance,NMR PROTACCRO10.42%PROTACBioassayCADD/AIDDE350PROTAC131PROTACCRO CROFIC 2,077CRO1,155689 •40,000•7,5765,552•64,56412,21010,800•77,50030%•7,5455,305•6,3625,335 •(CADD)(AIDD) •35,1682,5001,3001,500 (SBDD)CROCDMO 2,155.62,379.69.4%(1)EFS(2)CDMO 1,417.11,564.09.4% 738.5815.79.5%34.3% 87.167.628.8% 132.5130.81.3% 277.1273.61.3% 128.0135.85.7% EFS5% 11.7Anji Pharmaceuticals Inc., Tabomedex Biosciences, Inc., and VersaPeutics,Inc.364.2 8.19.4 321.7254.0 176.6184.74.4% 174.310.1 43.845.12.9% 99.8504.2 208.8133.9 1,036.3678.652.7%546.1 2,030.91,036.31,534.2949.51,544.9 50.5%54.5%1,532.0339.51,286.3585.220%949.5922.0 HLC VGC Partners HK II LimitedHuangshan Investments Pte. Ltd.True Light Investments H Pte. Ltd(i)547.7(ii)514.607.7 Raed Capital Holdings 2 LtdRaedRaed15,000,0001,536,6112.33% 207.1115.5196.07.1161.7 158.9349.8 51.0146.4 2,156.42,156.4 Synthesis HKCDMOCROCDMOBD 榮 4349 1 6225 • CROCMO • • • • EFSEFS • (i)(ii)(iii)(iv)(v)(vi) ISO 14001(PSCI)ES 2.4 30,016,0000.75% 41 14A 14A.71 28.1%30.0%19.6%18.1% 21.5%24.7%10.1%11.4% 5% 7 1 14 35 180 J.P. Morgan Securities plc1802.50%100%5.7456(i)4.5626.0%(ii)4.5925.1%1806(e)5.74565.112.618.3177.41,256.033 280 BVIJ.P. Morgan Securities plcBVI2801.00%100%11.6370(i)8.6235.0%(ii)8.3539.4%28011.6370186,519,8934.227.5275.81,801.6Viva Biotech Investment250,000,000256,521,0001,785,937,00033 470 470,000,0002%HLC VGC Partners HK II LimitedHuangshan Investments Pte. Ltd.True LightInvestments H Pte. Ltd470,000,000 2.01.905.26%235,000,000 470,000,0003336 97232 1011023,874.23,637.0 31 8,670,50011.2 (1) 250256.6 (1) BVI470,000,000 1641671011 20120736 1617 62CRO27BVI ••ZRG1AARR-1 (50)•Medicilon Inc. 45 61CRO15Viva ManagementVivaGT 64CROCRO14 • • 10 52Fenghe Fund Management Pte. Ltd. 502190 61Pharmacyclics, Inc. 李 向 榮 女 士51(HK.3389)HMIN(600258)MakeMyTrip LimitedMMYT 61 64(MRK)14 40CROIPO 40(CDMO) 37 49Vistra Corporate Services (HK) LimitedVistraVistra 23(Chartered Governance Institute) 13.2013.21 13.22 ••• C.2.1 兩 榮 43493.09D3.09D C.2.1 C.5.1 16C.5.1 1. 3.13 3.21C.4D.3榮榮榮3.10(2)3.21 55 •••• 3.25E.1榮榮E.1.2(c)17 55 10 B.3 55 50596069 4346 0.54:0.46 40% A.2.1 C.1.4 C.1.1 榮 9196 • 1)2)3) • • • • • • Vistra Corporate Services (HK) Limited 3.2915 1. 12.3 212150% 735201318+86 2160893288+86 2158243936info@vivabiotech.com www.vivabiotech.com XV(a)XV78(b)352(c) (i) (1)L(2)Mao Investment TrustMao Investment TrustMin Zhou 2018 Family TrustMZFT, LLCMZFT, LLCMin Zhou 2018 Family TrustCCMFT Trust SchemeThe Chen Mao Charitable Remainder TrustJ.P. Morgan Securities plcZhou MinZhou Min維 亞 生 物 科 技 控 股 集 團(3)維 亞 生 物 科 技 控 股 集 團(4)維 亞 生 物 科 技 控 股 集 團(5)HLC VGC Partners HK II LimitedHLC SPV85,000,000HLC SPVVGC Fund IV L.P.HLC VGC GP IV Limited+ (ii) (1)(2)Chencheney Ltd.100.0%Chencheney Ltd.Anji PharmaceuticalsClues Therapeutics(3)ChencheneyLtdClues Therapeutics Inc.447,039.0928%(4)5 XVXV78352 336 1.LS2.Mao and Sons LimitedZhang and Sons Limited JL and JSW Holding LimitedTIANL Holding Limited131,057,654Mao Investment Trust3.Fenghe Harvest LtdWu and Sons Limited100.00%Fenghe CanaryLimited45.00%Fenghe Harvest LtdWu and Sons LimitedFenghe CanaryLimitedFenghe Harvest LtdWu and Sons LimitedJ.P. Morgan Securities plc4.135,464(S)3,863,625(S)5.Huangshan Investments Pte. Ltd.True Light Investments H Pte. Ltd.Tamasek HoldingsPrivate Limited+ 336 1. (a) (i)270,937,30257,892,3512,194,55522.07% (ii) (iii) (iv)(i)422(ii)(a)(b) (v) (vi)(i)(a)10%110%(b)100%(ii)85%(iii) (vii) (viii) (ix) (1)40%20%20%20% 2. 1 i.0.1% ii.5(i)(ii)(iii) i. ii.iii. 10%150,000,000 10% 30%30% 121% 121% 11,820,00011,820,0002.892.6510.052.436 (1)(i)40%(ii)30%(iii)30% 60%90%120%9.70 (2)(i)60%(