方达控股2023年度报告

Frontage Holdings Corporation 方達控股公司 * （於開曼群島註冊成立的有限公司）股份代號 : 1521 2023年 度 報 告 * 僅供識別 目錄 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8. . . . . . . . . . . . . . . . . . . . . . . . . .36. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .45. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .87. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .116. . . . . . . . . . . . . . . . . . . . . . . . . . . .123. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .125. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .127. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .129. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .131. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245 Wells Fargo Bank, N.A. Morgan, Lewis & Bockius Yin Zhuan Conyers Dill & Pearman Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 700 Pennsylvania DriveExton, PA 19341, USA 700 Pennsylvania DriveExton, PA 19341, USA 3485 Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 1617 1521 www.frontagelab.com (1)20201231201912310.2 (2)2021123120201231 2023COVID-1920233.8% 2023 •202313AbdulMutlibFrontageLabsMutlib •2 0 2 38F r o n t a g eC a n a d a ,I n c .Nucro-TechnicsInc.Nucro-TechnicsHoldings,Inc.Nucro-TechnicsNucro-Technics5060,000(NaturalHealthProductRegulations) •20231231231,759 •(ADME/PK) •2023(Clinical Leader )(Life Science Leader )(ISR )(CRO Quality Benchmarking )20 •2023 ••• 2024328 2023(ADME) 20238Nucro-TechnicsNucro-TechnicsNucro-TechnicsNucro-TechnicsIND BRI 2023 202320221231250.43.8%20231231259.920231231342.220221231341.80.1% IND IND BiotranexIND John KapeghianDABTJohn BernalDVMStewartJacobson DVM DACVPStewartJacobson2023AAALACUSDAFDA(12) A(Pig-a)ICHE14S7BQT/QTc ADME/PK Nucro-TechnicsNucro-Technics50Nucro-TechnicsINDISO 9001:2015Nucro-TechnicsGLPGMP CMCBE11810,000 20236215,000NMPAGLPIND20233AAALACFDA (BSEP)(PAMPA)5030G(GPCRs) (ADC)(CGT) 89,000 20235(50)(4)(1) BEBEFDABE APICMC 2023COVID-19 2022I 20231231(12) •(3)•(2)•(1)•(1)•(1)•(1)•(1)•(1)•(1) 20231231(11) •(4)•(4)•(1)•(2) SOPs FDADEACNSCPHAC(CLIA/CAP)DOH AAALAC USDA DOHAAALACUSDA NMPA SOPsUSDA FrontageLabs(LifeScience Leader)(ClinicalLeader)2023 202320 Nucro-Technics Inc.Nucro-Technics Holdings Inc.100% 20238F r ont age C anada,In c .FrontageLabsNucro-Technics70,000,000410,431,000Nucro-Technics100%Nucro-Technics,Inc.60,000 2023815 2023616Frontage LabsAcceleraS.r.l.AcceleraNMSGroupS.p.A.Frontage LabsFrontage Europe S.r.l.Accelera6,835,000 202411Accelera IQVIAInstitute 20221231250.43.8%20231231259.9 20221231196.31.4%20231231199.120221231365.154.017.5%20231231428.960.8COVID-19GLP 2022123149.012.2%2023123143.02023123116.5%2022123119.6% 2022123163.35.4%2023123159.92023123123.0%2022123125.3% 20221231161.212.6%20231231181.5 2022123189.212.1%2023123178.42022123135.6%2023123130.2%2022123139.3%2023123133.2%2022123122.4%2023123120.4%(a)(b)(c) 202212314.214.3%202312314.8 202212312.5202312311.12022 202212317.213.9%202312318.2 2022123144.40.5%2023123144.62022123132.34.3%2023123133.7 (i)(ii) 202212313.953.8%202312316.0 202212313.982.1%202312317.1 2022123110.262.7%202312313.8 2022123125.958.7%2023123110.7202312314.1%2022123110.3%20221231(i)(ii) 2022123136.233.7%2023123124.0202312319.2%2022123114.4%20231231 12022123169.918.2%2023123157.22023123122.0%2022123127.9%58.7% 22022123173.213.7%2023123163.22022123129.3%2023123124.3% 202212310.012657.9%202312310.0053202212310.012357.7%202312310.0052 202312310.0118202212310.017633.0%202312310.0116202212310.017332.9% 20221231115.08.4%20231231124.7 2023123159.12022123165.29.4% 20221231149.223.3%20231231183.9Nucro-Technics 2023123137.22022123133.5 2022123157.66.4%2023123161.3 2022123117.76.2%2023123118.8 202312311.4 20.4% 2023123153.22022123187.4 20231231335.847.42022210.930.336.0202266.0 2023123121.22022123148.055.8% 2023123181.42022123148.956.4177.325.0 2023123163.72022123169.3 20231231 100%20232022123126.2%8.2% 202312311,7598519081,47828181%540 20231231112.220221231102.9 20182021 662021210202313 2001FrontageLabsFrontageLabsGreatValleyPharmaceuticals2014820184300347334715(PhiladelphiaAlliance for Capital and Technologies)(Healthcare CEO award)(Ernst & Young Entrepreneur ofthe Year Award)(Pennsylvania Welcoming Society)(Realizing the American Dream)(Asian American BusinessDevelopmentCenter)50(Outstanding50 AsianAmericans in Business)1992(McGill University) 692018416201862020212