方达控股2023中期报告

方達控股公司 * （於開曼群島註冊成立的有限公司）股份代號 : 1521 2023中 期 報 告 * 僅供識別 目錄 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27. . . . . . . . . . . . . . . . . . . . . . . . . . . .45. . . . . . . . . . . . . . . . . . . . . . . .47. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .48. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .50. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .52. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .53. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .91 Morgan, Lewis & Bockius Conyers Dill & Pearman Yin Zhuan Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 700 Pennsylvania DriveExton, PA 19341, USA 700 Pennsylvania DriveExton, PA 19341, USA 3485 Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 1617 1521 Wells Fargo Bank, N.A. www.frontagelab.com 537,048550,594338,959335,848198,089214,74677,52687,433 ADME 231,600 20230.959.02023(i)COVID-19(ii)2023COVID-19 2022630118.98.0%2023630128.42023630340.52022630315.38.0% 760(760 Pennsylvania Dr., Exton, PA)(CLIA/CLP)FDACLIAFDA(ADA)(NAb)ADANAb(PK)(PD) (NGS)293CLIA3%100%293Gemogenovatucel-TGemogenovatucel-T1(BRCA1)2(BRCA2)DNABRCA1BRCA2100%293NGSDNA(cfDNA)IlluminaTSO500CAPCAPNGS3 CGTCGTGMPCESPRAUCSEC-MALSLC/MSCGTCGTGMP 2023 BE11810,000 2023189,000 20235I504 2 0 2 362 1 5 , 0 0 0NMPA(GLP)IND(AAALAC)20233 1)(BSEP)(PAMPA) 2)5030G(GPCR) 3)FDAINDIND 4)ADCCGTADC 5)BEBEFDA API 2023COVID-19 2022I 2023630(12) •(3)•(2)•(1)•(1)•(1)•(1)•(1)•(1)•(1) 2023630(11) •(4)•(4)•(1)•(2) 2022630118.98.0%2023630128.4202263094.45.9%2023630100.02022630159.324.524.2%2023630197.828.4 202359.0202369.4 202352.8202347.211.9% 2023116.716.6202381.111.843.9%COVID-19GLP 202263021.90.5%202363022.0202363017.1%202263018.4% 202263029.92.3%202363030.6202363023.8%202263025.1% 202263074.719.7%202363089.42022 202263044.211.8%202363039.0202263037.2%202363030.4%202263041.8%202363034.8%202263019.4%202363014.8%(a)(b)(c) 20226303.417.6%20236304.0COVID-19 202263021.66%202363022.9202263015.712.1%202363017.6(i)(ii) (i)(ii) 20226301.693.8%20236303.1 20226301.4121.4%20236303.1 20226304.841.7%20236302.8 202263013.164.9%20236304.620236303.6%202263011.0%COVID-1920235.520230.92022630(i)(ii) 202263018.845.7%202363010.220236308.0%202263015.8%2022630 20238.320231.9 1202263032.515.4%202363027.5202363021.4%202263027.3%64.9% 2202263034.714.1%202363029.8202263029.2%202363023.2% 20226300.006363.5%20236300.002320226300.006163.9%20236300.0022 20236300.005020226300.009145.1%20236300.005020226300.0088 202363059.72022123165.28.4% 202363030.02022123133.510.4% 2022123157.63.5%202363059.6 2022123117.75.1%202363018.6 20236302.8 2022123137.529.3%202363026.5 10.3% 202363077.52022123187.4 202363011.5202263020.844.7% 202363051.52022123148.920236303.75%8%26.4181.125.1 202363063.92022123169.3 2023630 100%20236302022123110.3%8.2% 20236301,6137049091,32828581%546 202363053.5202263048.8 20182021 2023815F r o n t a g e L a b sFrontageCanada Inc.Nucro-TechnicsInc.NucroNucro-Technics Holdings, Inc.Nucro HoldingsNurco100%70,000,000410,431,00070,000,000 Nucro-Technics,Inc.60,000 Nucro HoldingsNucroNucro Holdings 2023815 193.220236302.6 2023630 20236302022630 2023630 20236302,000,0004,745,680 2023630 2023630 2023630C.2.1 C.2.1202313202313C.2.1Abdul Mutlib202313 20221231202363013.51B(1) •202313•Frontage Laboratories, Inc.202313•Abdul MutlibFrontage Laboratories, Inc.202313•YinZhuan33473003472023523 3.21 2023630XV(a)XV78(b)352(c) (1)201922820154,700,000202112520211,850,000202210720181,500,000202363034,633,050TheLinna Li GST ExemptTrustThe Wendy Li GST Exempt TrustThe Yue Monica Li GST Exempt Trust202363045,600,09045,602,09045,606,090 (2)201922820154,500,000202112520211,250,000(3)AbdulMutlib200820157,000,00020181,000,00020211252021975,000(4)20236302,058,579,910 2023630XVXV78352 2023630XV23336 (1)1,032,964,09038,742,000 (2)20236302,058,579,910 2023630XV23336 FrontageLabsFrontageLabsFrontage Labs20082015FrontageLabs9,434,43412,000,000FrontageLabs510 2018417Frontage LabsFrontageLabs201812314,035,000 201922820157,990,0002.00 201951110% (1)(2) 0.0160.200 202120155,001,0002023630 2019228 201922818%3% 20236302022630 2018 201951120182018 (i)2018 20182018 2018 (ii) 201820182018 (iii)2018 2018200,764,09110% 2018145,258,5917.1% (iv) 121% 2018 (v) 201810 (vi) 2018 (vii) 1.00 2018 (viii) a)b)c) 2018 (ix)2018 201820195301010 2023630 2018 202363020182018145,258,591145,258,591 20236302018829,0002022630 2021 202112220212021 (i)2021 2021 (ii