方达控股2024年度报告

（於開曼群島註冊成立的有限公司）股份代號 : 1521 2024年 度 報 告 目錄 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9. . . . . . . . . . . . . . . . . . . . . . . . . .35. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .45. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .85. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .113. . . . . . . . . . . . . . . . . . . . . . . . . . . .119. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .121. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .123. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .125. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .127. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .242 Wells Fargo Bank, N.A. Morgan, Lewis & Bockius Yin Zhuan Conyers Dill & Pearman Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 700 Pennsylvania DriveExton, PA 19341, USA 700 Pennsylvania DriveExton, PA 19341, USA 33191920 Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 1617 1521 www.frontagelab.com 2024 20231231259.91.9%20241231254.920241231390.620231231342.214.1% 2024202025 2024 • 202420241220242125 202516Wentao ZhangZhangZhongpingLinLinZhang2012Quintara Discovery, Inc.4Lin17FrontageLabsZhangLin • 202446,300PBMCDNAFFPE200,000 2024 • 20241Frontage LabsFrontage Europe S.r.l.AcceleraS.r.l.AcceleraAcceleraNMS Group S.p.A.Accelera Frontage LabsPharma Tech Outlook202420FrontageLabs • 2024 20242025 2025327 (IND)(FIH) 2024AcceleraAcceleraNMSGroup S.p.A.Accelera 202446,300 202420 2024 20231231259.91.9%20241231254.920241231390.620231231342.214.1% 202435%1 ADME/PK(ADC)50%PK PK202414C(hAME)(QWBA) hERGGLPAAALAC 46,3004°C-70°C-80°CPBMCDNAFFPE200,000 AcceleraAccelera 2024 (NMPA)2024 11810,000API 2024GLP89,000 PRMT5T2(AhR)NMPAINDUSP1APIFDA ADCp-Tau217(LDT)(Journal of Prevention of Alzheimer’s Disease)LDT(RWE) (BE)(FDA)BE 20241231(13) •(3)•(2)•(1)•(1)•(1)•(1)•(1)•(1)•(1)•(1) 20241231(11) •(4)•(4)•(1)•(2) SOPSOP FDADEACNSCPHAC(CLIA/CAP)DOHAAALACUSDA NMPA FrontageLabsZenQMSSOPKPI (SDWAN)SDWANSDWANGDPRISO27001NetSuiteSalesforce SOPUSDAFDA Frontage LabsPharma Tech Outlook202420 2023616Frontage LabsAcceleraNMS Group S.p.A.Frontage LabsFrontageEuropeAccelera6,835,000 202411Accelera 20241231 20241231 IIV2024834.920321,926.820242032(CAGR)11.1%2 (AI) 20 20231231259.91.9%20241231254.9 20231231199.10.5%20241231198.220231231428.960.85.9%20241231403.556.7 2023123143.013.5%2024123137.22024123114.6%2023123116.5% 2023123159.912.4%2024123152.52024123120.6%2023123123.0% 20231231181.52.0%20241231185.1NucroFrontageEurope2023820241NucroFrontageEurope 2023123178.411.0%2024123169.82023123130.2%2024123127.4%2023123133.2%2024123129.3%2023123120.4%2024123120.7% 202312314.810.4%202412314.3 202312311.1202412310.2 202312318.23.7%202412318.5 2023123144.65.6%2024123147.12023123133.74.2%2024123135.1NucroFrontage Europe2023820241 (i)(ii) 202312316.06.7%202412315.6 202312317.135.2%202412319.6 202312313.844.7%202412312.1 202412310.62023123110.7202412310.2%202312314.1%20231231 2023123124.045.0%2024123113.2202412315.2%202312319.2%20241231 32023123157.212.6%2024123150.02024123119.6%2023123122.0%NucroFrontage Europe 42023123163.214.6%2024123154.02023123124.3%2024123121.2% 202312310.0053202412310.0004202312310.0052202412310.0004 202412310.0066202312310.011844.1%202412310.0066202312310.0116 2024123154.32023123159.18.1% 2024123130.02023123137.219.4% 2023123161.312.7%2024123169.1 2023123138.750.1%2024123119.3Quintara 9.4% 2024123144.12023123153.2 2024123125.92023123121.222.2% 2024123195.72023123181.4202412312.75%6.73%71.0177.324.7 2024123158.72023123163.7 20241231 100%202412312023123133.0%26.2% 202412311,5608397211,29126984%562 20241231114.620231231112.2 20182021 672021210202313 2001FrontageLabsFrontageLabsGreatValleyPharmaceuticals2014820184300347334715(PhiladelphiaAlliance for Capital and Technologies)(Healthcare CEO award)(Ernst & Young Entrepreneur ofthe Year Award)(Pennsylvania Welcoming Society)(Realizing the American Dream)(Asian American BusinessDevelopmentCenter)50(Outstanding50 AsianAmericans in Business)1992(McGill University) 70201841620186202021210202271 201841720212102007420227FrontageLabsFrontageLabsSciosInc.2003MegabiosCorporation(Valentis,Inc.)197881993519959 Yin ZhuanYin59202261 3347300347Yin2023523Yin29Yin19952003200510200911YinYin1988719939(University of Massachusetts) 57 20201172020119948199910199910200212200312007720078200912010