礼来 2025年度报告

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2025.OR TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from __________________________to __________________________ Commission file number 001-06351 A.Full title of the plan and the address of the plan, if different from that of the issuer named below: B.Name of issuer of the securities held pursuant to the plan and the address of its principal executive office: Eli Lilly and CompanyLilly Corporate CenterIndianapolis, Indiana 46285 REQUIRED INFORMATION The following financial statements shall be furnished for the plan: 1.Not applicable.2.Not applicable.3.Not applicable.4.The Lilly Employee 401(k) Plan and The Savings Plan for Lilly Affiliate Employees in Puerto Rico (the Plans) are subject to therequirements of the Employee Retirement Income Security Act of 1974 (ERISA). Attached hereto are copies of the most recentfinancial statements and schedule of the Plans prepared in accordance with the financial reporting requirements of ERISA. The Lilly Employee 401(k) Plan and The Savings Plan for Lilly Affiliate Employees in Puerto Rico Financial Statements and Supplemental Schedules December 31, 2025 and 2024 and for the Year Ended December 31, 2025 Table of Contents Report of Independent Registered Public Accounting Firm Financial Statements Statements of Net Assets Available for Benefits- 20255Statements of Net Assets Available for Benefits- 20246Statements of Changes in Net Assets Available for Benefits7Notes to Financial Statements8 Supplemental Schedules Schedule of Assets (Held at End of Year)-The Lilly Employee 401(k) Plan19Schedule of Assets (Held at End of Year)-The Savings Plan for Lilly Affiliate Employees in Puerto Rico20Signatures21Exhibit 23 Consent of Independent Registered Public Accounting Firm23 Report of Independent Registered Public Accounting Firm To the Plan Participants and the Plan Administrator of The Lilly Employee 401(k) Plan and The Savings Planfor Lilly Affiliate Employees in Puerto Rico Opinion on the Financial Statements We have audited the accompanying statements of net assets available for benefits of The Lilly Employee 401(k)Plan and The Savings Plan for Lilly Affiliate Employees in Puerto Rico (the Plans) as of December 31, 2025and 2024, and the related statements of changes in net assets available for benefits for the year ended December31, 2025, and the related notes (collectively referred to as the “financial statements”). In our opinion, thefinancial statements present fairly, in all material respects, the net assets available for benefits of the Plans atDecember 31, 2025 and 2024, and the changes in their net assets available for benefits for the year endedDecember 31, 2025, in conformity with U.S. generally accepted accounting principles. Basis for Opinion These financial statements are the responsibility of the Plans’ management. Our responsibility is to express anopinion on the Plans’ financial statements based on our audits. We are a public accounting firm registered withthe Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independentwith respect to the Plans in accordance with the U.S. federal securities laws and the applicable rules andregulations of the Securities and Exchange Commission and the PCAOB. We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we planand perform the audit to obtain reasonable assurance about whether the financial statements are free of materialmisstatement, whether due to error or fraud. The Plans are not required to have, nor were we engaged toperform, an audit of their internal control over financial reporting. As part of our audits we are required toobtain an understanding of internal control over financial reporting but not for the purpose of expressing anopinion on the effectiveness of the Plans’ internal control over financial reporting. Accordingly, we express nosuch opinion. Our audits included performing procedures to assess the risks of material misstatement of the financialstatements, whether due to error or fraud, and performing procedures that respond to those risks. Suchprocedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financialstatements. Our audits also included evaluating the accounting principles used and significant estimates madeby management, as well as evaluating the overall presentation of the financial statements. We believe that ouraudits provide a reasonable basis for our opinion. Supplemental Schedules Required by ERISA The accompanying supplemental schedules of assets (held at end of year) as of December 31, 2025 (referred toas the “supplemental schedules”), have been subjected to audit procedures per