卡地纳健康 2025年度报告

Washington,D.C. 20549 FORM 11-K ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year endedDecember31, 2025 or TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ________ to ________ Commission File Number1-11373 A.Full title of the plan and the address of the plan, if different from that of the issuer named below:Cardinal Health 401(k) Savings Plan for Employees of Puerto Rico B.Name of the issuer of the securities held pursuant to the plan and the address of its principal executive office:Cardinal Health, Inc.7000 Cardinal PlaceDublin, Ohio 43017 Cardinal Health 401(k) Savings Plan for Employees of Puerto RicoFinancial Statements and Supplemental ScheduleYears Ended December31, 2025 and 2024 Table of Contents Report of Independent Registered Public Accounting Firm1 Financial Statements:Statements of Net Assets Available for BenefitsStatements of Changes in Net Assets Available for BenefitsNotes to Financial Statements Supplemental Schedule*:Schedule H, Line 4i on Form 5500: Schedule of Assets (Held at End of Year) Signature Exhibit:Consent of Independent Registered Public Accounting Firm Exhibit 23.1 *All other financial schedules required by Section 2520.103-10 of the U.S. Department of Labor’s Annual Reporting andDisclosure Requirements under the Employee Retirement Income Security Act of 1974, as amended, have beenomitted because they are not applicable. Report of Independent Registered Public Accounting Firm To the Plan Participants and the Plan Administrator of Cardinal Health 401(k) Savings Plan forEmployees of Puerto Rico Opinion on the Financial Statements We have audited the accompanying statements of net assets available for benefits of Cardinal Health 401(k) Savings Planfor Employees of Puerto Rico (the Plan) as of December31, 2025 and 2024, and the related statements of changes in netassets available for benefits for the years then ended, and the related notes (collectively referred to as the “financialstatements”). In our opinion, the financial statements present fairly, in all material respects, the net assets available forbenefits of the Plan at December31, 2025 and 2024, and the changes in its net assets available for benefits for the yearsthen ended, in conformity with U.S. generally accepted accounting principles. Basis for Opinion These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion onthe Plan’s financial statements based on our audits. We are a public accounting firm registered with the Public CompanyAccounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan inaccordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and ExchangeCommission and the PCAOB. We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan andperformthe audit to obtain reasonable assurance about whether the financial statements are free of materialmisstatement, whether due to error or fraud. The Plan is not required to have, nor were we engaged to perform, an auditof its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internalcontrol over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Plan’s internalcontrol over financial reporting. Accordingly, we express no such opinion. Our audits included performing procedures to assess the risks of material misstatement of the financial statements,whether due to error or fraud, and performing procedures that respond to those risks. Such procedures includedexamining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits alsoincluded evaluating the accounting principles used and significant estimates made by management, as well as evaluatingthe overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion. Supplemental Schedule Required by ERISA The accompanying supplemental schedule of assets (held at end of year) as of December31, 2025 (referred to as the“supplemental schedule”), has been subjected to audit procedures performed in conjunction with the audit of the Plan’sfinancial statements. The information in the supplemental schedule is the responsibility of the Plan’s management. Ouraudit procedures included determining whether the information reconciles to the financial statements or the underlyingaccounting and other records, as applicable, and performing procedures to test the completeness and accuracy of theinformation presented in the supplemental schedule. In forming our opinion on the information, we evaluated whether suchinformation, including its form and content, is presented in conformity with th