Illumina Inc 2025年度报告

Form10-K For the fiscal year ended December 28, 2025 or TRANSITION REPORT PURSUANT TO SECTION13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF1934For the transition period fromto Illumina, Inc.(Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization)(I.R.S. Employer Identification No.) Securities registered pursuant to Section12(b) of the Act: Securities registered pursuant to Section12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule405 of the Securities Act.YesNo Indicate by check mark if the registrant is not required to file reports pursuant to Section13 or Section15(d) of the Act.YesNo Indicate by check mark whether the registrant (1)has filed all reports required to be filed by Section13 or 15(d) of the Securities Exchange Act of 1934 during thepreceding 12months (or for such shorter period that the registrant was required to file such reports), and (2)has been subject to such filing requirements for the past90days.YesNo Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule405 of RegulationS-Tduring the preceding 12months (or for such shorter period that the registrant was required to submit such files).YesNo Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitionsof “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one): Accelerated filer☐Non-accelerated filer☐Smaller reporting company☐Emerging growth company If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revisedfinancial accounting standards provided pursuant to Section 13a of the Exchange Act. Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control overfinancial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its auditreport.☑ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of theregistrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). Indicate by check mark whether the registrant is a shell company (as defined in Rule12b-2 of the Exchange Act).Yes☐No As of February6, 2026, there were 152.9million shares (excluding 48.4millionshares held in treasury) of the registrant’s common stock outstanding. The aggregatemarket value of the common stock held by non-affiliates of the registrant as of June29, 2025 (the last business day of the registrant’s most recently completed secondquarter), based on the closing price for the common stock on The Nasdaq Global Select Market on June27, 2025 (the last trading day before June29, 2025), was$9.2billion. This excludes an aggregate of 57.1million shares of common stock held by officers and directors and each person known by the registrant to own 10% ormore of the outstanding common stock. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, directly orindirectly, to direct or cause the direction of the management or policies of the registrant, or that the registrant is controlled by or under common control with suchperson. DOCUMENTS INCORPORATED BY REFERENCEPortions of the registrant’s proxy statement for the 2026 annual meeting of stockholders are incorporated by reference into Items10 through 14 of PartIII of this Report. ILLUMINA, INC.FORM 10-KFOR THE FISCAL YEAR ENDED DECEMBER28, 2025TABLE OF CONTENTS Business Overview5Risk Factors15Legal Proceedings30Market Information30Share Repurchases and Sales32 Management’s Overview and Outlook33Results of Operations36Liquidity and Capital Resources40Critical Accounting Policies and Estimates42Quantitative and Qualitative Disclosures About Market Risk47Recent Accounting Pronouncements48 See “Form 10-K Cross-Reference Index” within Other Key Information for a cross-reference to the parts and itemsrequirements of the Securities and Exchange Commission Annual Report on Form 10-K. Consideration Regarding Forward-Looking Statements This Annual Report on Form 10-K contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of1995. Words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,”“strategy,” “future,” “likely,” “may,” “potential,” “pr