Illumina Inc美股招股说明书(2025-11-12版)

$500,000,000 $500,000,000 4.750% Notes due 2030 We are offering $500,000,000 aggregate principal amount of 4.750% notes due 2030 (the “Notes”). Interest on the Notes is payable semiannually inarrears on June 12 and December 12 of each year, beginning on June 12, 2026. The Notes will mature on December 12, 2030. We may redeem some orall of the Notes, at any time and from time to time, at our option at the redemption price calculated as described in this prospectus supplement. See“Description of Notes — Optional Redemption” in this prospectus supplement. If a change of control triggering event occurs with respect to the Notes,we will be required to offer to purchase all of the Notes from the holders at a purchase price equal to 101% of the principal amount thereof plus accruedand unpaid interest to, but excluding, the purchase date. See “Description of Notes — Change of Control Triggering Event” in this prospectussupplement. The Notes will be our unsecured and unsubordinated obligations and will rank equally with all of our other unsecured and unsubordinated indebtednessfrom time to time outstanding. The Notes will be issued only in book-entry form in minimum denominations of $2,000 and integral multiples of $1,000in excess thereof. The Notes are a new issue of securities with no established trading market. We do not intend to list the Notes on any securities exchange. Investing in the Notes involves risks. You should read carefully the entire accompanying prospectus and this prospectussupplement and the documents incorporated by reference herein and therein, including the section entitled “RiskFactors” beginning onpageS-5of this prospectus supplement. Neither the United States Securities and Exchange Commission nor any other state securities commission has approved or disapproved of theNotes or passed upon the accuracy or adequacy of this prospectus supplement or the accompanying prospectus. Any representation to thecontrary is a criminal offense. (1)Plus accrued interest, if any, from November 25, 2025, if settlement occurs after that date. See “Underwriting (Conflicts of Interest) — ExtendedSettlement”. We expect the Notes to be delivered in book-entry form only through the facilities of The Depository Trust Company for the accounts of its participants,including Clearstream Banking S.A. and Euroclear Bank SA/NV, against payment in New York, New York on or about November 25, 2025, which is thetenth U.S. business day following the date of this prospectus supplement (such settlement being referred to as “T+10”). See “Underwriting (Conflicts ofInterest) — Extended Settlement.” Joint Book-Running Managers GoldmanSachs&Co.LLCJ.P. Morgan BofASecuritiesBNP PARIBAS Co-Managers Table of Contents We have not, and the underwriters have not, authorized anyone to provide you with different or additional information from that contained orincorporated by reference in this prospectus supplement or the accompanying prospectus or any free writing prospectus to which we have referred you.We take no responsibility for, and can provide no assurance as to the reliability of, any information that others may give. This prospectus supplementand the accompanying prospectus do not constitute an offer to sell or the solicitation of an offer to buy any securities other than the securities describedin this prospectus supplement or an offer to sell or the solicitation of an offer to buy those securities in any circumstances in which such offer orsolicitation is unlawful. Neither the delivery of this prospectus supplement, the accompanying prospectus or any free writing prospectus prepared by usto which we have referred you, nor any sale made hereunder and thereunder shall, under any circumstances, create any implication that there has beenno change in our affairs since the date hereof or thereof or that the information contained or incorporated by reference herein or therein is correct as ofany time subsequent to the date of such information. Unless the context indicates otherwise, all references in this prospectus supplement and the accompanying prospectus to “we,” “us,” “our” and“Illumina” refer to Illumina, Inc., our consolidated subsidiaries or to all of them taken as a whole. Table of Contents TABLE OF CONTENTS Prospectus Supplement ABOUT THIS PROSPECTUS SUPPLEMENTFORWARD-LOOKING STATEMENTSWHERE YOU CAN FIND MORE INFORMATIONDOCUMENTS INCORPORATED BY REFERENCESUMMARYRISK FACTORSUSE OF PROCEEDSDESCRIPTION OF NOTESMATERIAL UNITED STATES FEDERAL TAX CONSIDERATIONSUNDERWRITING (CONFLICTS OF INTEREST)LEGAL MATTERSEXPERTS Prospectus ABOUT THIS PROSPECTUSRISK FACTORSDISCLOSURE REGARDING FORWARD-LOOKING STATEMENTSDOCUMENTS INCORPORATED BY REFERENCE INTO THIS PROSPECTUSTHE COMPANYUSE OF PROCEEDSDESCRIPTION OF SECURITIESDESCRIPTION OF DEBT SECURITIESDESCRIPTION OF CAPITAL STOCKDESCRIPTION OF WARRANTSDESCRIPTION OF STOCK PURCHASE CONTRACTS AND STOCK PURCHASE UNITSDESCRIPTION OF SUBSCRIPTION RIGHTSPLAN OF DISTRIBUTIONLEGAL M