基石药业-B2025年中期报告

(Incorporated in the Cayman Islands with limited liability)( 於開曼群島註冊成立的有限公司 )Stock Code股份代號 :2616 Interim Report中期報告2025 2 4 6 10 25 34 58 59 60 62 63 Paul Herbert ChewKenneth Howard Jarrett Kenneth Walton Hitchner III Kenneth Walton Hitchner III Paul Herbert ChewKenneth Howard Jarrett Paul Herbert ChewKenneth Howard Jarrett www.cstonepharma.com Vistra (Cayman) LimitedP.O. Box 31119, Grand PavilionHibiscus Way802 West Bay RoadGrand Cayman KY1-1205Cayman Islands Paul Herbert Chew Paul Herbert Chew 717710 218C1 24840 2616 •8835 Walkers Corporate LimitedCayman Corporate Centre27 Hospital RoadGeorge TownGrand Cayman KY1-9008Cayman Islands 183171712-1716 826 •254.2204.880.5%49.420.217.911.3(1)(2)Istituto GentiliGentili •82.160.1142.2 •66.239.0105.2 •46.73.243.5 •62.827.135.7 •270.215.7285.9 •652.8 •71.031.1102.1 •109.632.477.2•265.110.8275.9 •®PD-L1 IVNSCLCEMAIIINSCLCCRTIIINSCLCPD-(L)1 SteinCares10LATAMGentili2360 •GEMSTONE-303GC/GEJCPFSOSJAMA(GEMSTONE-302IVNSCLC•(Lancet Oncology) •ESMONSCLCNSCLCI, A •®(RET) ®100mg •®KIT/PDGFRA ®300mg100mg® •CS5001ROR1ADC Ib CS5001CS5001R-CHOP++++BDLBCLCS5001SOCDLBCLDLTIICS5001 •CS2009PD-1/VEGF/CTLA-4 I/II CS2009I/IIIIIPKPDESMOII FICBICI/O I61-45mg/kgCS2009 • (DLT) •PK/PD PDCS2009PD-1/CTLA-4TVEGFA • PD-(L)1 •NofazinlimabPD-1 CS1003-305 CS1003-305IIInofazinlimabOSPFSORR INDADC ADCFIC/BIC2.0 ADC2.0ADCCS5007EGFR3HER3ADCCS50052SSTR2 ADCCS5008δ3DLL3SSTR2ADCCS5006β4ITGB4ADCCS5009B7H3/PD-L1ADC AACRCS2009PD-1/VEGF/CTLA-4CS2011EGFR/HER3CS5007EGFR/HER3ADCCS5006(ITGB4ADC)CS5005(SSTR2 ADC) CS2013BBAFFAPRILCS2015OX40OX40LTSLPFIC/BICIND • CS5001(ROR1ADC)CS2009PD-1/VEGF/CTLA-4 • ®® • ADCESMOASH 18A.08(3) 26164916NDAADC16 16–/ •®PD-L1 PD-L1OmniRat®G4(IgG4) •IVNSCLC(EGFR)(ALK)NSCLCNSCLC •IIINSCLCIIINSCLC •NK/TNK/T•E S C CESCC•G/GEJPD-L1CPS≥5G/GEJ ECMHRA®EGFRALK1ROS1RETNSCLCEMAIIINSCLCIIIIVNSCLC E w o p h a r m aP h a r m a l i n kSteinCares10Gentili2360Gentili1.92550%Gentili •ESMO®NSCLCI,A •GEMSTONE-303G/GEJCPS≥5PFSO SGEMSTONE-302• RET ®RETRETNSCLCRETNSCLCRETMTCRETTCR E TNSCLCTFDARETNSCLCRETTC ®®® ®100mg ®11NSCLCTC®CSCONSCLCRET®RETNSCLC®IVRETNSCLCCSCO •®KIT/PDGFRA ®KIT/PDGFRAPDGFRA18PDGFRAD842VGIST®TFDAPDGFRA D842VGIST ® ®®PDGFRA18PDGFRAD842VGIST ®CSCO CS5001LCB71 ROR1 ADCIb •C S 5 0 0 1R O R 1A D CC S 5 0 0 1pyrrolobenzodiazepinePBD(Payload)(linker)CS5001PBDPBDPBDCS5001CS5001CS5001DARCS5001ROR1 ADC •CS5001Ia/IbIbIIIbCS5001DLBCL CS5001R-CHOPDLBCLCS5001DLBCLCS5001ROR1CS5001 CS2009PD-1/VEGF/CTLA-4I/OI/II •CS20092.0PD-1/VEGF/CTLA-4PD-1CTLA-4VEGFACS2009TPD-1CTLA-4TCTLA-4TMETMEVEGFACS2009PD-1CTLA-4 •CS2009I/IIII100 I61-45mg/kgCS2009 •DLT•PK/PDPDCS2009PD-1/CTLA-4TVEGFA•PD-(L)1 IPKPDESMO CS1002SHR-8068CTLA-4III •CS1002/SHR-8068CS1002 •CS1002/SHR-8068 II/IIICS1002/SHR-8068NSCLC IIICS1002/SHR-8068HCCCS1002/SHR-8068CRCIIINDIIICS1002/SHR-8068PD-L1TPS1%NSCLC NofazinlimabCS1003PD-1 •CS1003-305III74PD-1nofazinlimab(CS1003)LENVIMA®HCCOSBICRPFSORR •nofazinlimabOSPFSORRnofazinlimabPD-(L)1 IND ADC •A D CA D Cβ A D CA D C2.0A D CC S5005( S S T R2A D C )C S5008D L L3& S S T R2A D CCS5006(ITGB4 ADC)CS5007 EGFR&HER3ADCCS5009B7H3/PD-L1ADC •ADC CS5007EGFR/HER3ADCCS5007EGFR/HER3(CS2011)βexatecanCS5007EGFRHER3EGFRHER3CS5007CS5007NSCLCSCCHNCRC CS5005(SSTR2 ADC)CS5008SSTR2/DLL3ADCCS5005SSTR2βIexatecanNENSCLCSSTR2CS5008DLL3/SSTR2ADCNENSCLCSSTR2DLL3CS5008 CS5006(ITGB4ADC)CS5006ITGB4ADCITGB4α6(ITGA6)(α6β4)NSCLCSCCHNCRC • CS2013BAFF/APRILCS2013BBAFFAPRILCS2013SLERAIgAIgANB CS2015OX40L/TSLPCS2015OX40LTSLPTh2ADCOPD 18A.08(3) EwopharmaPharmalinkSteinCaresGentili ®® PD-L1®Ewopharma18PharmalinkMENASteinCaresGentili 254.2204.880.5%49.420.217.911.3(1)(2)Gentili 82.160.1142.2 14.85.59.3 12.98.34.6 66.239.0105.215.435.951.3 46.73.243.55.32.72.6 62.827.135.753.519.633.9 8.31.46.9 939218 12.00186,396,0000.0001146,294.762,090.16H.10 13.37115,928,803200.01,355.9 8 4 , 8 0 0 , 0 0 04.6336.61%389.07338.12 2.93380,000,0005.86%232.29215.82 652.8672.9 1 0 0 %73.6%73.9% 363,200,000 M.D.,Ph.D.61 30®®®®4PD-L1 BGNE6160688235PD-1BTKPARPRAF(FIH)PD-1 CovanceInc.Tularik Inc.Amgen Inc. 8010+JAMANatureMedicine•TheLancetOncologyJCONatureCancerClinicalCancer Research15 MichaelS.BrownJosephL.GoldsteinStuartL.Schreiber Ph.D.53 20CreacionVentures6Dimensions Capital,L.P.WuXiHealthcareVenturesII,L.P.1477 MBA KennethWalton Hitchner III65Hitchner Hitchner30 HitchnerProvidentAcquisition Corp.PAQCValianceAssetManagementHitchner Hitchner2269HitchnerElementsAdvisors SPVAntler6032592359HitchnerHH&LAcquisitionCo.HHLAHitchnerCydar MedicalSphere Fluidics2268 Hitchner 62 •1228 •AmbrxBiopharma Inc.AMAM•2269•Viela Bio Inc.VIE•WuXiPharmaTech(Cayman)Inc.•TanoxInc.TNOXGenentech Inc.•BiogenInc.BIIB• (Carnegie Mellon University) GBS,JP71 87001140611051515000625001477 (Teesside Polytechnic) 56 (DHgate Holdings Limited) PhoenixNewMediaLimitedFENGA8A8800A8 LJInternational,Inc.JADELorenzoJewelry LimitedArthur Ander