Inotiv Inc美股招股说明书(2025-07-18版)

Offered by the Selling Shareholders (collectively, the “Prospectus”), covering the resale by the selling shareholders named in the Prospectus of 4,146,250 of our commonshares issued or issuable upon the exercise of certain Warrant Certificates with an exercise price of $1.57 per share (the “Warrants”).The purpose of this Prospectus Supplement No. 2 is solely to supplement and update the “Selling Shareholders” table in the SPV, LLC for no consideration on July 11, 2025.This Prospectus Supplement No. 2 is not complete without, and may not be utilized except in connection with, the Prospectus, except to the extent that the information provided by this Prospectus Supplement No. 2 supersedes information contained in theProspectus.Our common shares are traded on The Nasdaq Capital Market under the symbol “NOTV.” On July 17, 2025, the last reported sale Investing in our securities involves risks. See “Risk Factors” on page4of the prospectus for a discussion of information that should be considered in connection with an investment in our securities.Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal NumberofCommonShares Being OfferedSelling Shareholder(s)NumberPercentage