欧洲艾滋病毒预防和护理标准：暴露前预防模块

ECDCOPERATIONAL SUPPORTEuropean standards of HIV prevention andcare: Module on pre-exposure prophylaxis iiThis report by the European Centre for Disease Prevention and Control (ECDC) was coordinated by Teymur Noori.The draft version was produced under a specific contract with the European Centre for Disease Prevention andControl (ECDC). The European AIDS Clinical Society (EACS) was awarded this specific contract under ‘Europeanstandards of HIV care’ (service contract number: ECDC/2022/0210)This report on standards of care for Pre-Exposure Prophylaxis is one in a series of standards for HIV care. Otherreports in the series can be found on ECDC’s website athttps://www.ecdc.europa.eu/en/infectious-disease-topics/hiv-infection-and-aids/ecdceacs-standards-hiv-careECDC would like to acknowledge the support, guidance, and quality assurance throughout the duration of theproject provided by members of the Standards of Care Advisory group: Alma Cicic (Montenegro), Caroline Hurley(Ireland), Cianán Russell (ILGA-Europe), Cristina Mussini (Italy), Cristiana Oprea (Romania), Deniz Gökengin(Türkiye), Dominique Van Beckhoven (Belgium), Ferenc Bagyinszky (Germany), Georg Behrens (Germany), JoseBernardino (Spain), Omar Syarif (GNP+),Teymur Noori (ECDC).ECDC would also like to thank the technical writing group for their time, energy, and technical expertise in thedrafting of the Standards of Care: Writinggroup Lead Miłosz Parczewski (Poland), Alma Cicic (Montenegro), AnnaKoval (Ukraine), Ann Sullivan (UK), Bartosz Szetela (Poland), Bogusz Aksak-Wąs (Poland), Caroline Hurley(Ireland), Cianán Russell (ILGA-Europe), Deniz Gökengin (Türkiye), Eva Orviz (Spain), Ferenc Bagyinszky(Germany), Fiona Burns (UK), Georg Behrens, (Germany), Jean-Michel Molina (France), Jessika Deblonde(Belgium), Omar Syarif (GNP+), Pep Coll (Spain), Sime Zekan (Croatia).ECDC would also like to thank the SoC project Core Group members for their dedicated support to preparing theapplication for this project, providing day-to-day support to the working process; Ann Sullivan (Expert EACS),Daniel Simões (Expert Community), Dorthe Raben (CHIP), Esteban Martinez (Expert EACS), Fiona Burns (ExpertEACS), Jürgen Rockstroh (Expert EACS), Joelle Verluyten (EACS), Miłosz Parczewski (Expert EACS), Sanjay Bhagani(Expert EACS).ECDC would also like to thank the European Standard of Care Coordination team in EACS and CHIP for jointlycoordinating the work and ensuring support to all phases of the project. The project team consists of JoelleVerluyten (EACS) and Dorthe Raben (CHIP) including project coordinators, Anne Raahauge, Susanne Olejas (CHIP)and Olga Fursa (CHIP).Suggested citation: European Centre for Disease Prevention and Control. European standards of HIV preventionand care: Module on pre-exposure prophylaxis. Stockholm: ECDC; 2025.Stockholm, June 2025ISBN 978-92-9498-806-5doi: 10.2900/4677371Catalogue number TQ-01-25-036-EN-N© European Centre for Disease Prevention and Control, 2025Reproduction is authorised, provided the source is acknowledged ContentsAbbreviations ........................................................................................................................................................................ivBackground and introduction.................................................................................................................................................. 5Methodology ......................................................................................................................................................................... 61. Access to pre-exposure prophylaxis (PrEP) .......................................................................................................................... 72. PrEP initiation, including safety aspects ............................................................................................................................... 83. Continuum of pre-exposure prophylaxis care (including adherence and post-exposure prophylaxis) ...................................... 104. Pre-exposure prophylaxis delivery, integrated services, and combination prevention ............................................................ 115. Staff training ................................................................................................................................................................... 136. Monitoring and evaluation ................................................................................................................................................ 14Applying the standards ........................................................................................................................................................ 14References .......................................................................................................................................................................... 15Annex 1. Contributors to the development of the stan