关于指定未来欧洲公共卫生参考实验室的快速欧洲疾病预防控制中心建议

2of EURLs is still under consideration. When relevant, it also contains recommendations for changes to thesteps of the general EURL implementation process.A list of all currently designated EURLs, including all consortium members and coordinators, is available on theDG SANTE website [5].Decisions on which EURL(s) to be implemented and on general EURL implementation processes are made by DGSANTE.3. Proposed EURL(s) for implementation3.1 Proposed EURL for implementation in 2025/2026The ECDC proposal on the diseases/health issues for EURL implementation in 2025/2026 is listed inTable 1. Thisis based on an assessment according to the methodology described under Methods (section6.1) below. Weighingthe factors described for all remaining disease/health issues where EURLs have not yet been designated,respiratory viruses were identified as the best candidate for implementation in2025/2026.Table 1. ECDC proposal on diseases/health issues for EURL implementation in 2025/2026EURLDisease(s)/health issuesSupporting diseasenetwork(s)RationaleRespiratory virusesInfluenza virus (seasonal, emerging/pandemicand human infections of zoonotic influenzavirus), SARS-CoV-2 and RSV. The scope ofthe EURL should also include other respiratoryviruses of epidemic and/or pandemicpotential, such as SARS-CoV, MERS-CoV,enterovirus D68, adenovirus and humanmetapneumovirus.Viral respiratory diseasesnetworks of ECDC.Respiratory viruses are a highpriority for EU-levelsurveillance due to existinghigh burden of disease andpandemic potential; ensuringadequate laboratory supportas well as training andcapacity-building are essentialto continued pandemicpreparedness and high-qualityEU surveillance activities forpublic health.3.1.1Related changes to the networks supported by the proposedEURL to be implemented in 2025/2026Should a decision be made to implement the EURL for respiratory diseases as proposed in section3.1 above,ECDC would explore the possibility of merging the two networks ERLI-Net and ECOVID-LabNet. This is mainlydue to strong synergy effects identified between the network activities and a high degree of overlap betweennetwork members. In addition, ECDC would also propose to Member States that Operational Contact Points arealso nominated for RSV, to ensure that the EURL would be able to contact the relevant Member Staterepresentatives for activities focusing on RSV.Once a decision has been made by SANTE, in-depth discussions with the two networks should be initiated withthe goal to discuss and agree on a plan for how these network merges should be managed.3.2Proposed EURLs for implementation in coming yearsECDC recommends that over the coming years, EURLs should also be established for the diseases/health issueslisted inTable 2. Recommendations for specific timepoints for implementation of these EURLs will be assessedaccording to the methodology described under Methods (section6.1) below. 34Additional diseases/health issues underconsideration for EURL implementationIn addition to the proposed list of EURLs for implementation, Table 3 contains a list of additional diseases/healthissues/pathogens or their vectors under consideration for EU-level laboratory support under the EURL system.Depending on the stakeholders’ opinion on the usefulness and public health added value of laboratory support forthese diseases, these may be added to the list of EURLs for implementation in future revisions of this rapidscientific advice.ECDC recommends that in 2025 SANTE and ECDC should carry out a structured stakeholder consultation toassess the need for, potential benefits and estimated costs of implementing EURLs for these diseases/healthissues/pathogens or their vectors. Stakeholders to be consulted should include Member States (disease networkmembers, National Focal Points for Microbiology, ECDC Advisory Forum, Heath Security Committee) as well asother relevant initiatives relevant to these topics.Table 3. Additional diseases/health issues under consideration for EURL implementationPotential EURLfunctionDisease(s)/healthissuesSupporting diseasenetwork(s)RationaleArthropod vectorsArthropod vectors,including mosquitoes, ticks,sand flies, and bitingmidges; lice, fleas, mites,etc.EVD-NetWith climate change, arthropod vectors’distributions have been expanding, and the riskof disease outbreaks have been increasing. Thelack of an EU reference laboratory for vectorspecies identification, assessment of vectorcompetence and vectorial capacity, as well asmonitoring of insecticide resistance, is a barrierto adequate preparedness and response tovector-borne diseases.As many vector-borne diseases are zoonotic, thisEURL should be developed taking a One Healthapproach, and cover arthropods of both publichealth and animal health relevance. Ideally, thisEURL should be mandated to evaluate andmonitor cost-effectiveness of vector controlmethods and contribute to the detection ofpathogens in vectors in cooperation withpathogen-specific EURLs.PrionsAll prion diseases, inc