278 683 1484 3186 3787 5788 152 2024157 1617 33191918 1 120 1 www.totbiopharm.com.cn 12 1875 1 ESG1 • (1)20253 12(a)(b)(c)ESG(d)(e)(f)ESG 20253 21(a)(b) ADCNMPACDMOCDMO CDMO4 202412 31 202410 (ADC)ADCADCADC ADCBDKcellTMGMP12g/LCMCDisacLinkTMADCCDMOCDMOADC pre–BLA NMPAFDAGMPPMDACDMO 2025CDMOCDMO 20253 11 EBITDAEBITDA EBITDAEBITDAEBITDA EBITDA EBITDAEBITDA 202431,43720238,1622024EBITDA106,7342023EBITDA40,041CDMO 20241,098,3292023780,629317,70041%202434,757202337,757202479,3132023103,890202481,375202368,3102024606,7112023441,019 CDMO/CMO 2024877,4102023630,207247,203® 2024CDMO/CMO207,1332023140,89866,235CDMO/CMO CDMO 202479,3132023103,89024,577ADC CDMO 2024606,7112023441,019165,692 202481,375202368,31013,065 20248,005202311,481 202418,216202317,654562 20243,38320232,974409 20249,88020235,1754,705 202420231 202434,757202337,757 202412 31729,6552023686,68642,969 202412 31381,2562023351,60029,656 2024116,403202356,43159,972CDMO122,5052023164,10541,60034,183202338,2254,042 202412 31394,013202312 31344,285299,050202312 31265,71528 (1)(2)(3) 20242023 202111 91.8202112 3183,500202112 31202412 318,35043,489 2021ADC202412 3114,821 202412 31 202412 31 202412 31 202412 31 202412 31611202412 31 2024205,0322023174,463 202412 312023202412 31 2024CDMO124CDMOCDMOCDMOCDMO 2024CDMOCDMOADCXDCADCGMPADCXDC CDMO ®2025 2024116,403 •CDMO34,757 202412 31 •CDMO 58ADC 48153 •1,098,32941% •877,41039%®CDMO/CMO207,13347% 2pre-BLA8CDMO 1.9139% (ADC) 1. 2024ADCADC2000ADC17ADC2023ADC10ADCADC201820202310439.1%2023203030.3%2030ADC662 2.ADC CDMOADC ADCADCCDMOADCADC CDMOADC CDMOADCADCADCADC CDMO CDMO 1.CDMO ADCXDC 2.CDMO –2.1· ••ADCCDMO 202412 31 •CDMO/CMO207,13347%ADC86%•5848ADC•8pre-BLA2•MNC• ADC PMDACDMO –2.2GMP ICH Q10FDAALOCA+GMPGMP(NMPA)FDAGMPGMPGMP202438GMP7GMP342QP1GMP (DMS)(ERP)(EMS)VAISALA(LIMS)(ELN) XDCGL-DisacLink®ADCCMC CDMOGMP 2024OSHydroTrioOSADC/BioconjugatesOSADC –2.3 ADCCDMO 20237GL-DisacLink™ ADCCDMO ADCpre-BLACDMOADC CDMO HydroTrioDAR 2.5CDMO 2024CDMO15+202412 31CDMOCDMO –2.4 422ADC54303,000ADC9605302023CDMOCDMOADC 75%ADC CDMO17%85%2024CDMO –2.6 CDMO2024ADCXDC 2024CDMO 20223TAB014(wAMD)TAB014(MAH)20251B (6622.HK)TAB014IIITAB014 18A.05 202442%2024123134202025 ® ®202120241231®Avastin®1002030490202120307.6%2030184202120308.3%®2022® ® ®2021531NMPA2021®2022202412 31 2024CDMOADC/XDC/AXCCDMOCDMO GMPADCCDMO20,000LADC100L500L5kg6,000~50,000GMPADCADC 2024 •20244XDCXDCAb/ADC/XDCCDMOADC •20246(CBA-China)ADC/XDCCDMOADCCBA-ChinaCBA-China •20246BiG&ADCADCCDMO •20249BioJapanBioJapan •202410ADCSAPA-China 2024ADC •202411ADC&XDCGL-DisacLink® •202411World ADC(ADCs)World ADCADC 2024CDMO CDMO 57201610 17201810 2620193 12202010 15ESG201610 17202010 1520204 21202010 15 201072016102005420107Bayer USLLCBayer Healthcare 20021219917 19864201512201141983719858 5720161 1920189 28ESG 201310(VivoCapital LLC)2008620131020216229120187Sinovac Biotech Ltd.SVA201811256120253202132021620243GenetronHoldings LimitedGTH20182202339969688428 1982619836 5620238 12ESG CMC20011020155ArrayBioPharma Inc.ARRY(PfizerInc.)PFE2015620162Avista Pharma SolutionsCambrex CorporationCBM20163201742359603259 1991719887 6620107 520201015ESG20107 5202010 1520231 1 20211220243 20178(Vivo Capital LLC)20191120216(Genetron Holdings Limited)GTH 199792002120176 198919942000 5620253 12 5320253 12 20221020094 2022120226CTHAtlas TechnologyGroup LLC2019920206SoftBank Investment Advisers (US) Inc.201762018122000112017617 199172002720032 6920253 12ESG 60202311ADC30 202410Linbio Consulting LLC20148202492269JNJPPD Inc.TMO 2014920231022692268(Sigma Aldrich)(DuPont-MerckPharmaceuticals)(Amgen) 1982719891120015 482024720 6120241(MS&T) 20149202412269Pharmaceutical Product Development, Inc.Thermo Fisher Scientific, Inc.TMOBristol Myers Squibb CompanyBMY 201211202311Novartis AGNVSMS&T(Novo Nordisk)(Eli Lilly) 198619892003 (Wincor Nixdorf AG)WIN2016(Diebold Nixdorf, Inc.)DBD 5120233CMC 201912023318776881802014201815130005132012201420072012Shire HGT(Takeda) 19982005(Universität Paderborn)2005(Diplom-Kauffrau)(FCMA)(CGMA)(HKICPA) 422019420174201932011920173 199520002007 2003720091 442022120244 52201612019420142201512200912011920028200811 2021620211020161120215(Fuba Automotive Electronics GmbH)2019820051120169(Wincor Nixdorf International GmbH) 20022005(FIPA)(FFA) 19956 462014122019420074201410EPS2002720074 20027 45202052024420222 1 2017120205Flex Ltd.FLEX20127201612Multi-Fineline Electronix,Inc.MFLX2008320125Canadian Solar Inc.CSIQ20022003 202412 31 C1 202412 31 • •••• 2022CSOCSO2022CSO2024CSOCSOCSOCSO 20253 21 C3 202412 31 20253 1220253 1220253 1220253 1220253 1220253 12 20253 1220253 113.09D 3136 Vivo Capital LLC C.5.1 C.2.7 202412 31 202412 31 20241231 –2024 202412 31 42.9% ESG 3.13 B.2.2 202412 31C.1.4 202412 31 20253 1220253 1220253 1220253 1220253 1220253 12 A B • ESG • • • 2 • 20253 213.10(2)3.