东曜药业-B2023年中期报告

225 326 27 18 45 2256 2 20238 1220238 12 1617 3485 20238 1220238 12 120 www.totbiopharm.com.cn 20238 1220238 12 1875 ESG20238 1220238 12 • CDMOADC CDMO20236 30CDMO4596%ADC 2814ADC(RDC)3pre-BLAADCADC CDMO 2023 ADCCDMOADC CDMO 2023202215,72415,16349,96962,413 2023328,06380%2023202249,4342023147%277,881167%®CDMO/CMO46,546105%116%62,413 ADC CDMO2023DisacLink™ ADCADC TAE020TAC020CDMO 1 20232 18A.05 2022® 2 ® 20232023161%®20236 302082023 ®20236 30®ADC1002030490202120307.6%2030184202120308.3%® ® ® AIDSAIDS®2021513NMPAAIDSAIDS125mg/mL150mL ®20215 31NMPA2021®202220236 30 ®® 2.ADC (ADC) –ADC 1. ADCADCADCADC202279203064730%ADCADC 20214,10020257,10214.7%2030ADC2023ADCADC ADCADC20235700ADC15200ADC CDMO ADC CDMOADC ADCCMCADCCDMO70%34% ADC CDMO2022152018202234.5%21.8%2030ADC CDMO1102022203028.4%ADCADC CDMO CDMO 2.ADC CDMO 1.CDMO 2023 2023ADC CDMOCDMOCDMOCDMO/CMO46,546105%20236 304596%ADCADC 2862% •ADC •ADCADC ADC2015ADC3pre-BLAADC17IND2 •(RDC) •CDMOADCCDMOADCIND ADC 3.CDMO –3.1•ADC ADC•ADCCDMOADCADC20,000L3ADC2ADCADC 3.2 – ADCCDMO2023DisacLink™ADCDisacLink™CDMOADCDisacLink™ADC DisacLink™ADC 200L500L2,000L20,000LADC3ADC2ADCADC 3.3 2022QP 3.5 CDMO – CDMOCDMOCDMOCDMO13%80%CDMO83% –3.4 ADC•ADCADC –3.6 CDMO20233pre-BLAADC •GMPADCOEB-5ADC100L200L500L5kg 1 2023 •200L500L 2,000L •ADCSyntegon40(2*20m2)Kyowa2R-50R200(RTP)100% 2 GMPADCADC CDMO CDMOADC/XDC/AXCCDMOCDMO •20234ADC •20235ADCADCADC •20235BIONNOVA CDMOADC CDMO • • • • ADC CDMOXDC/AXC 2023328,0632022182,019146,04480%202315,163202215,7245614%202349,969202270,268202331,104202225,6982023197,376202270,091 CDMO 202349,969202270,26820,299 2023197,376202270,091127,285 CDMO/CMO 2023277,8812022104,170173,711167%® 2023CDMO/CMO46,546202222,65723,889105%CDMO/CMO 202331,104202225,6985,406 2023630708,0502022715,4397,389 20231,2782022415863 20236 30432,9752022417,76915,206 202362,413202228,85233,56184,748202263,41121,33734,085202233,383702 20232,26120223,4181,157 202312022 2023202215,72415,163 2021ADC20236 3028,618 2023630328,482202212 31287,633311,018202212 31237,36713 20236 30 20236 300.52022 12 310.4 2023 202111 91.8202112 3183,500202112 3120236 3022,41957,834 20236 30 20236 30 20236 3046320236 30 (1) 202380,899202260,831 1 200912 43485 CDMOCMO 201911 8 20238 11 2 2.1 20236 3034 202212 31 20236 30202212 31622436 622662(3)63202212 31 2 2.1 (a) 12 i> ii> 12 2 2.1 3 3.1 20221231 202212 31 3 3.2 3 3.3 13 1 22 33 20236 30202212 31 • • 20236 3020226 30 20236 3012 320226 30 4 2022 5 (a) CDMO/CMO (b) 5 (c) (d) 5 (e) 2017110 84,500,00020236 3055,500,00020236 30202263032,400,00029,000,000 2022110 30,000,00020236 3020226 3020,000,0005,000,000 CDMO/CMO115 (f) 202320226 30 6 7 8 (a) 8 (b) 202363020226 30202320226 30202320226 30 11 (a) 11 (a) 20236 30202212 31 (b) 12 (a)20227293.15150,000,000(i)33,750,000(ii)116,250,000472,500,000405,788,000 (b)202211 120227,558,390 20236 30202212 3147,590,948 13 (a)20236 3041,100,0002.95%4.00%230,000,000202212 3175,500,0003.80%4.00%100,000,000 (b)2023630287,382,0003.50%4.20%81,018,000202212 31212,133,0003.80%4.25%137,367,000 13 20236 30202212 31 20236 30311,018,000202212 31237,367,000 14 14 20236 30202212 31 15 20236 30202212 31 16 (a) (b) 17 202320226 3020236 30202212 31 (a) 17 (b) (i) (ii) (c) (i) 17 (c) (iv) (d) 20211015 (i) 20236 30XVXV78352 (1)L(2)20236 30772,787,887(3)(4)Teeroy Limited 20236 30XV78352 20236 30XV23336 (1)L (2)20236 30772,787,887 (3)Advantech Capital Investment V Limited49,136,800Advantech CapitalInvestment V LimitedAdvantech Capital II Master Investment LimitedAdvantech Capital II L.P.Advantech Capital II L.P.Advantech Capital II L.P.Advantech Capital Partners II LimitedAdvantech Capital Partners II LimitedAdvantech Capital II Master Investment LimitedAdvantech Capital II L.P.Advantech Capital Partners IILimitedAdvantech Capital Investment V Limited (4)56,573,500Chengwei Evergreen Capital,L.P.Chengwei Evergreen Capital, L.P.Chengwei EvergreenManagement, LLCChengwei Evergreen Capital, L.P.Chengwei EvergreenManagement, LLC (5)Vivo Capital Fund VIII, L.P.90,718,100Vivo Capital Surplus Fund VIII, L.P.12,526,900Vivo Capital Fund VIII, L.P.Vivo Capital Surplus Fund VIII, L.P.Vivo CapitalVivo CapitalVivo Capital VIII, LLCVivo Capital LLCVivo CapitalVivo Capital VIII, LLCVivo Capital VIII, LLCVivo Capital LLCVivo Capital (6)116,250,000 (7)Tricor Trust (Hong Kong) Limited20205 2938,993,566 20236 30XV23336 20132 20201712 11201812 2020193 1220194 1620197 22 V-36V-47202212 3127 20236 30 202211 187,558,390202212 307,558,390 20205 29(i)(ii)20207 29202112 23202211 17 20236305,274,9130.68%202212315,274,913Tricor Trust(Hong Kong) Limited10,330,831202212318,474,304 20208 3821202112 23(1)(2)(3)202211 1(1)(2)(3)(4)202212 8202212 3127 57,000,0005,700,000202114,250,000202112 2320211223(1)(2)(3) 20205 298431,413,7962020122830,466,6