三生制药2024 中期报告

(於開曼群島註冊成立的有限公司)股份代號：1530Convertible Bonds Code 40285 中期報告 23562638404142444648 rhEPOrhTPOIQVIA1266.2%rhEPOrhEPO42.7%TNF 282515761210RABRVO411 16pegsiticase1PD-1 5,6079,700 Cricket Square, Hutchins DrivePO Box 2681Grand Cayman, KY1-1111Cayman Islands 13 3485 Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DrivePO Box 2681Grand Cayman, KY1-1111Cayman Islands () 97927 183171712–1716 •97914 01530 www.3sbio.com 77334 77 Conyers Dill & Pearman8129 •605.616.0%4,389.4•595.818.6%3,797.484.6%86.5%•109.311.1%1,089.9316.71.5%1,112.4•EBITDA311.023.4%1,641.5EBITDA4241.617.0%1,663.9* 5% IIIROGAINE® ITP ITP ITPITP 2.74,500(MAH) rhTPOCITITPITPCITITP CITITP(CSCO)CTIT20245rhTPOI20216rhTPO20207rhTPOITPITPITP20198rhTPOCITrhTPO 1)IL2)3)34.5%66.2%ITPNDAIII CKDCIArhEPOrhEPOrhEPOrhEPO10,000 IU1)2)3)4)5) IITNFRAASRAASTNFCMATNFRATNFRATNFEULAR2022(GRAPPA)20219301SNDA FcHER2HER2(CSCO)20242024HER2HER2HER2 OTCAGAFDA1)2)3)AGA20225%(FAGA) 1)2)3)5% 2.53%-4% ® TRK-820Remitch®NDATRK-820® TRK-82010HBV9,000HCV1,00070017,300–31,0006,2004620%–70%20%–60%20%–50%5.1%–58.4%HCV8%–36.2%HBV1157.8%Remitch TRK-820 CDMO CDMOSirton Pharmaceuticals S.p.A.Sirton500GMPCDMO7.6 Winlevi® Cosmo Pharmaceuticals N.V.Cosmo1%WS204CosmoCassiopeaWinlevi® 201995%3%–7%11025 WS2041%CosmoAR12Winlevi®FDA40FDA(MOA)1%CosmoWinlevi®15,000109WS204AR SSS06NuPIAOrhEPO608IL-17ACS1003PD-1601ABRVOVEGF613IL-1ßRD-01rhEPO611ADIL4R610IL-5SSS07RATNFpegsiticaseHIF-117SSS17HIF(Winlevi®) 700 282515761210RABRVO411 (1)(2)IND(3)BE(4)ANDA (MN709)5% (rhTPO)ITPNDAIIINDA (TRK820)TRK820IIINDA NuPIAO (EPO, SSS06)SSS06 Pegsiticase (SSS11)Swedish Orphan Biovitrum ABSOBISobiSEL-212SobiFDA(BLA)SEL-212pegsiticasepegadricaseSSS11b IL-17A(608)608BLA608 VEGF(601A)601ABRVO (WS204)WS204 IL-4R(611)AD611AD611(CRSwNP)611 IL-1ß(613)613613 IL-5(610)610 PD-1/VEGF(707)707PD-L1707707CLF2PD-1/VEGFFDA HIF-117(SSS17)SSS17SSS17HIFHIFSSS17rhEPO IND NGF(SSS40)(NGF)SSS40Ib/IIa (SSS39)SSS39 BDCA2(626)(SLE)(CLE)INDIND 2,7781,1891,7862,9006,80016 2023–2027CDMO 608IL-17A 4,389.43,783.8605.616.0% 2,475.92,019.1456.822.6%56.4% 515.7463.252.511.3%393.1365.927.27.4%122.697.425.225.9%11.7% 557.2508.848.49.5%549.8499.850.010.0%12.7% 328.69.5%7.5% (1)(2)476.2415.660.614.6%161.7108.653.148.9% 582.3592.113.5% 3,797.43,201.6595.818.6%84.6%86.5% 86.1-7.293.3 1,594.01,374.8219.215.9%36.3% 201.2214.413.26.2%4.6%5.7% 476.2306.6169.655.3%10.8%8.1% 40.75.135.6 104.488.915.517.4%104.465.538.859.2% 314.3207.6106.751.4%22.1%17.4% EBITDA EBITDA1,641.51,330.5311.023.4%EBITDAEBITDA(a)(b)(c)(d)(e)(f)EBITDA1,663.91,422.3241.617.0% 1,089.9980.6109.311.1%(a)(b)(c)(d)(e)(f)1,112.41,095.716.71.5% 0.450.4012.4% 1,092.71,184.591.87.7%7,944.5 3,847.55,465.12.51.7 2,966.53,574.32,071.61,482.9 1,200.71,226.018 29.3%25.0% 977.8993.6 (1) Sirton(2)32.30.7%Sirton(1)99.5708.9(2)363.7332.0(3)2.519.1 (i)586.7(ii)3,542.6(iii)2,139.05.0% 1,0001,100 5,6075,411721.9604.4 C1 C.2.1 C3 13.51B(1) • • • • • 61 • 13.51B(1) 2410 43,346,500266,284,34022,119,50021,227,000 XVXV78352C3 (2)440,000440,00041,746,0009,410,895476,774,553 (3)24,384,630440,000440,000 (4)80,00080,000 (ii) (1)4.08% (2)0.036%0.032% XVXV78352 336 (L)*(1)2,416,800,912(2)DSLCSLCSLDSL476,774,553Lambda International LimitedCSL 42.52%35.65%476,774,553(3)(4)TMF (Cayman) Ltd.476,774,55351,156,89516,486,00032,668,480TMF (Cayman) Ltd. 336 5.242,439,85710.03%225,953,857225,953,8570 121%1.00 0.5 # 1% 20 Tricor Trust (Hong Kong) LimitedTricor Trust (Hong Kong) Limited (i)40,357,688487,784,0821.67%20.18%(ii)40,357,6881.67%0 4.5 20 (1)3710,000,00020(2)10,000,0005,000,0002,250,000(3)(4)(5)17 4079343434 2410 34 1. CricketSquare, Hutchins Drive, P.O. Box 2681, Grand Cayman, KY1-1111, Cayman Islands 2. 2.1 34 2.2 161177 2. 2.2 (a)1616 (b)12 (c)77 3. 10% 4. 5. 6. 7. 8. 25%Sirton Pharmaceuticals S.p.A.Sirton27.9% 8. 15% 10% 9. 25 10. 1,089,942,000980,577,0002,429,790,6872,438,919,579 11. 11. 2,679,0002,748,000 39,436,00040,218,000 1,083,345,0002,679,0002,748,00031,920,00090,680,00017 12. 13. 14. 177,664,000195,432,000 15. 16. 18. 1,200,000,0001004.20% 19. 19. 20. The Empire TrustTMF (Cayman) Ltd.TMF20,000,0009.10 20,000,00020,000,00020,000,000TMF7.627.307.62 16,486,0000.68% 20. 3710,000,0009,885,44832 (%)(%)(%)(%) 44.830.8617.0010.005.12 9,885,4481,626,000 10,000,00010,000,00084,400,0002,750,0000.11% 20. 4.002,670,6002,243,500427,10013933 808,000 21. 131.4131.1401.02 22. 23. Medical Recovery LimitedMedical Recovery 23. (a) 23. (b) (i)10,000,0004.35%3.29%155,000157,000 (ii)30,000,0003.48%2.50%4,391,00030,000,000548,000 55,000,0003.15%5,203,00055,000,000894,000 1,100,000 (iii)Medical Recovery30,000,000Medical Recovery4.00%3,085,0006,486,000Medical RecoveryThe Sun Shine TrustThe Sun Shine TrustMedical Recovery 23. (c) 24. 24. EBITDAEV/EBITDA 24. 24. 24. 24. 25. 11.95925,174,500 26.