和铂医药-B2023年年报

年度報告2023 24891318404681100102107108109111113116202 P.O. Box 472, Harbour Place, 2nd Floor 103South Church Street, George Town GrandCayman KY1-1106Cayman Islands 218A3202 Robert Irwin KamenAlbert R. Collinson 3485 International Corporation Services Ltd.P.O. Box 472, Harbour Place, 2nd Floor 103South Church Street, George Town GrandCayman KY1-1106, Cayman Islands 1617 Robert Irwin Kamen 201623 97927 www.harbourbiomed.com 02142 HarbourTherapeuticsHarbourTherapeutics HarbourTherapeuticsHBM9161HBM4003HBM7008HBM1020 (HBM9161) FcRnFcRnIgGIgGFcRngMGIII HBM4003 HBM4003CTLA-4T4(CTLA-4)THCAbHBM4003CTLA-4CTLA-4CTLA-4HBM4003TPKADCCTregHBM4003HBM4003CTLA-4 HBM7008 HBM7008B7H44-1BBTTHBM7008HBICE®PD-L1PD1/PD-L14-1BBCullinan Oncology, Inc.CullinanCullinanB7H4x4-1BB(HBM7008) HBM1020 HBM1020Harbour Mice®B7H7B7B7H7PD-L1HBM1020B7H7B7H7PD-L1PD-(L)1PD-L1B7H7IHBM1020 HBM1022(CCR8)HBM1007CD73HBM9378TSLPHBM1047CD200R1HBICE®HBM7020(BCMAxCD3)HBM9027(PD-L1xCD40)HBM7022(CLDN18.2xCD3)HBM7004(B7H4xCD3)HarbourMice®HBM9033MSLNADC HBM4003Harbour Mice®Harbour Mice®(H2L2)(HCAb)H2L2(H2L2)HCAbmRNAADCHCAbHBICE®HCAbB I to ITMINDHarbourMice®B HCAb HarbourTherapeutics50 HarbourMice®HCAb PlusTMI to ITM HARBOUR THERAPEUTICS a.gMGIII 2.(HBM4003) PD-1HCC a.(ASCO)HCCIb PD-1NET/NEC b.AACRNENIb 3.HBM9378 a.Ib.I 4.HBM1020 a.FDAINDIb.I 5. a.HBM1007FDAINDIb.HBM1022FDAINDIc.HBM9027FDAINDI 1. a.HBM7022HBICE®FDANMPAINDI/II b.Cullinan Oncology Inc.CullinanCullinanHBM7008c.HBM9033HarbourMice®MSLNd.INDIND 2. a.Harbour Mice®b.6160Harbour Mice®H2L2Harbour Mice®c.ADCADC d.M y t h i cT h e r a p e u t i c sM y t h i cTherapeuticsADCe.(mAbs)(WEEV)(SFTSV)f.PIRCHarbour Mice®g.OPKO HealthModeX TherapeuticsModeXh.INGENIATherapeuticsHarbour Mice®i.j.LyciaTherapeuticsHarbour Mice HCAbLYTACModeXk.Harbour Mice® 3. a.HBM Alpha TherapeuticsHBMATb.NKASCONK-010NK-010FDAINDI a.Front ImmunolSARS-CoV-2b.AACRNET/NECIc.ASCOHCCId.e.HBM7008f.PEGSHBM9014R1055g.Festival of Biologics U.S.HCAbHarbour Mice®h.CAR-TCR(CAR-TCRsummit)CAR-TCARi.mRNA(mRNA Therapy Summit)mRNAT HarbourTherapeutics INDHarbourBioMedHarbourMice®HBICE® HarbourTherapeuticsHarbourTherapeuticsIND/IND HBM4003HBM4003CTLA-4HCAbHBM4003II HBM1020FDAINDIHBM1020Harbour Mice®B7H7B7B7H7PD-L1HBM1020B7H7HBM1020 HBM7008B7H44-1BBHBM7008HBICE®HBM7008HBICE®HBM7008ICullinan HBM9378IHBM9378HBM9378 H B M1022H B M1007HBM1020HBM1022HBM1007HBM9033FDAINDHBM9027FDAIND HBM7004HBM1047HBM9014IND HARBOUR THERAPEUTICS HarbourTherapeuticsHBM7008CullinanHBM7022NMPAINDHBM9378IHBICE® HarbourBioMed(Suzhou)CO., LTD)IdeaINDHCAb HBM9033MSLNADCHCAbPlusTM HarbourTherapeuticsHarbourTherapeutics TNK HARBOUR THERAPEUTICS HarbourTherapeutics HarbourMice®(H2L2)(HCAb)HCAb(HBICE®)B Ito ITMINDHarbour Mice®B HarbourTherapeutics 10 HARBOUR THERAPEUTICS HarbourTherapeutics (HBM9161) gMGIIIIIIgMG(HBM9161)gMGBLANMPANMPABLA(HBM9161)BLAgMGNMPAHBM9161 (HBM4003) HBM4003HCAbCTLA-4HBM4003NET/NECHCC PD-1NET/NEC A.AACR(HBM4003)Ib IbHBM4003NEN(PK)(PD)NEN(pts)(Q3W)0.3mg/kg0.45mg/kg+240mg(RECIST)1.1(ORR) NEN(ORR)(DCR)38.9%61.1%3(DOR)80%DORNECORRDCR38.5%69.2% PD-1HCC B.ASCO(HBM4003)HCCIb IbHBM4003HCC(PK)(PD)12HCC(n=28)(Q3W)0.45mg/kg+240mg1VEGFRPD-(L)1(n=16)2PD-(L)1VEGFR(n=12)RECIST 1.1(ORR) 115ORR(DCR)46.7%73.3%211ORRDCR9.1%RECIST18.2%54.5% 1Treg HBM9378 HBM9378HBM9378 H B M9378H2L2TSLPTSLPTSLPDCT helper 2 (Th2)HBM9378HBM9378 HBM9378II HBM1020 HBM1020H2L2B7H7 B7H7HHLA2B7B7TB7PD-(L)1CTLA-4B7B7B7H7PD-L1PD-L1PD-(L)1PD-L1B7H7 INDI IND 1.HBM1022 HBM1022GGPCRCCR8CCR8TTHBM1022CCR8 CCR8TregGPCRGPCRCCR8TregTTreg HBM1022CCR8GPCRHBM1022CCR8T HBM1022FDAINDI 2.HBM1007 HBM1007H2L2CD73CD73(AMP)CD73HBM1007CD73AMP(TME)CD73CD73 HBM1007FDAINDI 3.HBM9027 HBM9027PD-L1×CD40HBICE®Harbour Mice®PD-L1×CD40PD-L1×CD40HBICE®DCHBICE® •PD-1/PD-L1CD40•T••CD40CD40•T HBM9027FDAINDI 4.HBM7004 HBM7004B7H4xCD3HBICE®HarbourMice®(H2L2HCAbB7H4xCD3HBICE®HBICE® •B7H4B7H4T•CD3•TMHC-TCR••B7H4x4-1BB 5.HBM9014 H B M 9 0 1 4L I F RHarbour Mice® •LIFRIL6IL6•• 6.HBM1047 HBM1047CD200R1HarbourMice®(H2L2)HBM1047CD200R1THBM1047CD200CD200R1 •HBM1047CD200R1•HBM1047T•HBM1047•HBM1047PK•HBM1047200mg/kg HARBOUR THERAPEUTICS HarbourTherapeutics 1.HBM7022 HBM7022HBM7022HBICE®FDANMPAINDI/II 2.HBM7008Cullinan Oncology CullinanCullinanHBM7008 3. HBM1029HBM7015HBM7020INDI 4. HBMATHBMATHBM9013CMC 5.NK AASCONK-010NK-010FDAINDI IdeaIND 1.HBM9033 HBM90335310.5 1. HarbourMice®HarbourMice® 2. HarbourMice®H2L2Harbour Mice®Harbour Mice®HCAb 3. ADCADC 4.Mythic Therapeutics Mythic TherapeuticsMythic TherapeuticsADCMythic Therapeutics(HCAb)Mythic TherapeuticsFateControl™ 5. Michael S. Diamond(mAbs)(WEEV)(SFTSV) 6.PIRC PIRCHarbourMice®H2L2HCAbPIRC 7.ModeX Therapeutics OPKO HealthModeX TherapeuticsModeXModeXHarbourMice®ModeXMSTAR 8.INGENIA Therapeutics INGENIATherapeuticsINGENIA 9. iLDCiGDCHarbour Mice® 10.Lycia Therapeutics LyciaTherapeuticsLycia TherapeuticsHarbour Mice®HCAbLYTAC 11. Harbour Mice® •8251280 •S