和铂医药-B2024年年报

2459133540769698103104105107109112202 Robert Irwin KamenAlbert R. Collinson P.O. Box 472, Harbour Place, 2nd Floor103 South Church Street, George TownGrand Cayman KY1-1106Cayman Islands Albert R. Collinson 218A3202 Albert R. Collinson 33191918 International Corporation Services Ltd.P.O. Box 472, Harbour Place, 2nd Floor103 South Church Street, George TownGrand Cayman KY1-1106, Cayman Islands Robert Irwin Kamen 1617 201623 97927 www.harbourbiomed.com 02142 HARBOUR THERAPEUTICS 1.(HBM9161) gMGBLANMPA 2.HBM9378/WIN378 NMPACOPDINDIND Windward BioII 3.(HBM4003) PD-1CRC 4.HBM1020 I 5. HBM9027FDAINDI 1. a.LSE/STO/NasdaqAZN1910575b.Candid Therapeutics, Inc.CandidTTCE320Candidc.WindwardBioWindwardBioHBM9378/WIN378970 2. a.Boostimmune,Inc.BoostimmuneADCb.Alaya.bioCAR-Tc.UmojaBiopharmaUmojaBiopharmaCAR-Td.Alkyon Therapeutics, Inc.(AlkyonTx)HarbourMice® e.OverTBioOverTBioHCAb Harbour Mice®CARHCAbNonaCarFxTM f.KodiakSciences Inc.KODHarbour Mice® 3. a.HBMAlpha TherapeuticsHBMATb.NKA++ a.•b.Ic.ESMOB7H7HBM1020Id.Toxicon:Xe.SARS-CoV-2f.AACRClaudin-18.2CAR-T g.mRNATCARh.TFR1i.j.15TTk.9CAR-TCRNonaCarFxTMBCMA HarbourTherapeutics IdeaINDHarbour BioMedHarbour Mice®HBICE®HBICATMB HarbourTherapeuticsHarbourTherapeuticsINDIND 8 gMGBLAHBM9378COPDIND T200 HBICE®Harbour Mice® HBICE®HBM9027PD-L1xCD40FDAINDPD-L1×CD40DC Harbour BioMed (Suzhou) CO.,LTD)IdeaINDHCAb CandidTherapeuticsT HarbourTherapeuticsHarbourTherapeutics TADC HarbourTherapeuticsIdeaIND HARBOUR THERAPEUTICS HarbourTherapeutics HarbourMice®(H2L2)(HCAb)HCAb(HBICE®)HCAb(HBICATM)B IITM IdeaINDHarbourMice®B HarbourTherapeutics HarbourTherapeutics HarbourTherapeutics (HBM9161) FcRnFcRnGIgGIgGFcRn FcRngMGIIIIIIgMGgMGgMG (HBM9161)gMGBLANMPANMPABLA NMPA(HBM9161)BLA (HBM9161)gMGBLANMPA •gMG IIIHBM9161 HBM9378 HBM9378H2L2HBM9378TSLPTSLPTSLPDCT helper 2 (Th2)HBM9378HBM9378 NMPAINDI NMPACOPDINDINDNMPA Windward Bio WindwardBioWindwardBioHBM9378/WIN378 WindwardBioWindwardBioWindwardBioII (HBM4003) HBM4003CTLA-4T4(CTLA-4)THCAbHBM4003CTLA-4CTLA-4CTLA-4HBM4003T(ADCC)TregHBM4003HBM4003CTLA-4 HBM4003PD-1 PD-1 PD-123ORR1PR(DCR)30.4%47.8% IPD-1/PD-L1(ORR)33.3%PD-1/PD-L1ORR40.0% HBM1020 HBM1020Harbour Mice®B7H7B7B7H7PD-L1PD-L1HBM1020B7H7HBM1020PD-L1PD-(L)1I ESMOHBM1020157(46.7%)(SD)11%25% HBM7008 HBM7008(TAA)B7H44-1BBTAATTHBM7008HBICE®PD-L1PD1/PD-L14-1BB Cullinan Therapeutics, Inc.Cullinan Oncology, Inc.CullinanCullinanB7H4x4-1BB(HBM7008) CullinanCullinanCullinanHBM7008 IND H B I C E®HBM9027(PD-L1xCD40)HBM7004 (B7H4xCD3)Harbour Mice®HBM9033MSLNADCADC/RDC 1.HBM7020 H B M7020H B I C E®H a r b o u rM i c e®BCMAxCD3HBM7020BCMACD3TTBCMACD3CRSHBM7020 HBM7020NMPAINDI IND 2.HBM9027 HBM9027PD-L1×CD40HBICE®Harbour Mice®PD-L1×CD40 HBICE®PD-L1×CD40DCHBICE® HBM9027FDAINDI 3.HBM7004 HBM7004B7H4xCD3HBICE®HarbourMice®H2L2HCAbB7H4xCD3HBICE®HBICE® HBM7004B7H4THBM7004HBM7004B7H4x4-1BB HBM7004IND 4.HBM9014 H B M 9 0 1 4L I F RH a r b o u rM i c e®L I F RI L6HBM9014IL6 H B M9014HBM9014 IdeaIND 1.HBM9033 HBM9033HarbourMice®ADCI 2. 1910575 3.Candid CandidTherapeutics,Inc.CandidTTCE320Candid 4.Windward Bio WindwardBioWindwardBioHBM9378970HBM9378/WIN37845WindwardBioWindward BioWindwardBioWindward Bio 5.HBM Alpha Therapeutics (HBMAT) HBM Alpha Therapeutics(CRH)HAT001HBM9013CRHHBMAT395HBMAT 1.Boostimmune BoostimmuneADCHarbourMice®H2L2ADC 2.Alaya.bio Alaya.bioCAR-THCAbHarbour Mice®Alaya. bioCAR-T 3.Umoja Biopharma UmojaBiopharmaUmoja BiopharmaCAR-THCAbHarbour Mice®CARHCAb(Nona CarFx™)UmojaVivo Vec™CAR-T 4.Alkyon Therapeutics, Inc. AlkyonTherapeutics,Inc.(AlkyonTx)HarbourMice®(ECM)Alkyon 5.OverT Bio OverTBioHCAb Harbour Mice®CARHCAbNonaCarFxTM 6.Kodiak Sciences Inc. KodiakSciences Inc.KODHarbourMice® ••HBM9161 •I •ESMOB7H7HBM1020I •40516296 HCAb-CARmRNA •Toxicon: X•SARS-CoV-2•CARAACR•mRNAT •TFR1 •9CAR-TCRNonaCarFxTMBCMA 18A.08(3) NKNK15.8%15.8%AA++10.90% 7.633.55%1.88 5% AstraZenecaHoldings B.V.1.3810.749.15%105.3819.2 17544 HarbourTherapeuticsINDHarbourMice®HBICATMHBICE® 38.189.55.716.921.045.124.153.4%13.219.56.332.3%6.64.669.7%11.22.7130.7 5.711.2196.5%16.9 4.52.02.5 6.611.2 45.124.153.4%21.0 (i)(ii)14.210.4 19.513.210.48.0 1.40.2 2.7 71.9% (1) (2) (3) 0.90.7 59.41.9 156252 23.71.226.3 M.D.Ph.D.60HBM Holdings BVIHBM Therapeutics 1521 (theCommonwealth of Massachusetts Boardof Registration in Medicine)(the American Board of Internal Medicine)(the State Board of Medicine of the Commonwealth of Pennsylvania) Ph.D.47 SMII RobertIrwin KamenPh.D.80KamenKamenHarbourAntibodiesHarbourAntibodiesKamen KamenImperialCancer Research FundGenetics Institute, Inc.BASFResearch CorporationKamenOxfordBioscience PartnersThird Rock Ventures Kamen •Jounce TherapeuticsJNCE •N e o nT h e r a p e u t i c sN T G NBiopharmaceutical New TechnologiesBNTX Kamen(theEuropean Molecular Biology Organization) Ph.D.62 3003473347 300244 AlbertR.CollinsonPh.D.6730CollinsonTheracos,Inc.2Collinso