复旦张江截至二零二三年六月三十日止六个月中期报告

中 期 報 告截 至 二 零 二 三 年 六 月 三 十 日 止 六 個 月 5.2392.74% 11 1 IQVIA3-6%1.93.70%2,2143,4984,574 2 WHO4.21.5925.59266.693,0044,71811.95% 2 HPVHPV20030HPV-611 16 180.5%5%80%-90%TCABCA5(ALA) 75%-80%65%40 3 57.27%406.40223.43182.96IQVIA3,700 3() DNRADMEPITHPMIT PEG 1)® ®®® ®®®® 2)复美達® 复美達®LED 1)® ®www.menet.com.cn264469.23% 1. 1. (1) ADCADClinker-drugBB05Me-betterADC ADCADC ADCCD30DM1ITrop2SN38FDA018IHer2BB05FDA022ITrop2Trop2BB05FZ-AD004ICDEIDLL3DLL3BB05 (2) 1. (2) ®复美達®II ® 复美達®65%40复美達®IV复美達® ®®20142017 ALA 1. (2) HPVIIcIIAKII (3) EPR ®®10ml:20mg (4) 1. (4) (WD-1603)IIUGi-PumpRIIIPBC 2. Her2BB05FDA022I Trop2BB05FZ-AD004ICDEI 3. 4. 4. 1 5. % 6. 1. 1. 2. --1 3. 4. cGMPFDAEMAcGMPCAPA cGMP cGMP 5. 5.2392.74%HPV®®复美達®99.83% Me-too - 1. 2. 1. ®®复美達® 1. 1. Me-too- ®复美達®®92.74%HPV®®复美達®99.83%- ICH ADCADC 复美達®昂內達®IIII4442,000ADC 1. 1.2. 1. %%%100,099,3913.30172,740,2465.80-42.058,945,6780.3017,987,1400.60-50.27––33,320,6251.12-100.008,682,8850.294,057,2180.14114.01366,6790.01604,2410.02-39.32Kintara 1. (i) HA 1,231,128,499 1. (ii) 100,000 37,8752.7% 46,6542.7% 15,4712.7% (iii) (iv) IIII4442,00060,0001,265ADC 1.(vi)(vii) 2. 1)3,968,7200.13%2) 1. 299,338234,7858%- 5% (1) 1. (2)(3) Adgero Biopharmaceuticals Holdings, IncAdgeroAdgeroDelMar Phamarceuticals, IncNASDAQDPMIDelmarDelmarAdergoDelmarKintara Therapeutics,IncNASDAQKTRAKintaraKintaraKintara12,592KintaraKintara366,679 A2.02625 I3.084IIA1.584 A1.9147146 I1.585IIA1.585 1.5027 A 1,028 1 2 3 A 1234 H 12 12345678A9101111.111.2 12 13 13.113.213.3 14 14.1 14.2 15A 1 2 3 12345 101010 AAAAH A3,8003,277258523125 7,572,100A38,000,000A15,723,000AA3.69%1.52% A16.73A9.34A9.35 (1) (2) a)b)c)d)e)f)g)h)i)j)k)l)m)n) (2) C.2.1 C.2.1 (3) 10 (4) 3.10(1)3.10(2)3.21 (5) 911817116,719,64183,322,505 (6) 103.97 1 2 (1) (2) 2 (3) 3 117.651 A 1 23 1234 123 123 123 A107,400.009,967.6197,432.39 1A23AA45248,307,075.73246,430,652.001,876,423.7369,600 1 2 3 35,000- 4 A9,600 1 2 434,357,902 7,572,100A 4 21,67221,672A21,563H136 571XV23336 12,030,000A1,980,000H50,000 27,572,100A 3 4 123 (a)XV7 8(b)352(c) 1L23 A 2023630 2023630 2023630 2023630 20236306 20236306 20236306 2023630620226306 51,342,057(51,562,444) 20236306 20236306 20236306 20236306 2023630620226306 66,861,643– 66,861,643– (2,705,716)–(4,857,461)(12,858,552) (7,563,177)(12,858,552) 59,298,466(12,858,552) –– (39,492,994)1,713,3771,187,769,1371,083,259,371 1,148,276,1431,084,972,748 20236306 20236306 20236306 20236306 199611115,295,000 200010205,295,00053,000,000 200011853,000,00053,000,0001 20021 20153,000,0000.10530,000,000 20028 13198,000,0000.10H71,000,000710,000,0000.1 2012629201324H92,300,000923,000,0000.1 20131216H 20206 12120,000,0000.10A2020619104,300,0001,043,000,0000.1 20226 714,000,000H1,043,000,0001,029,000,0000.1 20235 112021205A7,572,1000.1103,657,210 20236306 2023810 (8))(9))(11)(13)(22))(13))(18)) (25) 20236306 (1) 200621515 201433 (2) 20236306202363020236306 (3) 111231 (4) (5) 20236306 (6) (7) (a) (b) (8) (a) (i) (1)(2)(3) 20236306 (8) (a) (i) (ii) 20236306 (8) (a) (ii) 12 12 12 20236306 (8) (a) (iii) (1)(2)(3) (b) (c) (9) (a) (b) 20236306 (9) (c) (d) (e) (10) (a) (b) 20236306 (10) (b) (c) (d) (15)) (e) 20236306 (11) (a) (b) (c)(15)) (d) (12) (15)) 20236306 (13) (a) 47-50 (b) 5-10 (c) 5-10 (d) 3-10 (e) 20236306 (13) (f) (g) (15)) (14) (15) 20236306 (15) (16) (a) (b) (17) (18) (8)) 20236306 (18) (a) (b) (c) (19) (20) 20236306 (21) (22) 12 20236306 (22) (1)(2) (23) (1)(2)(3) (24) 20236306 (25) (a) (i) (ii) (b) (i) (ii) 20236306 (25) (b) (iii) 510 (iv) (1)15%25% 20236306 (a)2020GR20203100626432023630615%2022630615% 2022GR202231000054320236 30615%20226 30615%2023630620226306 2021GR20213200743232023630 615%20226 30615%2023630620226306 2018112,000,0008.25%16.5%2023630620226306 20236306 (1) 202363020221231 (a)2023630 (b)2023630 (i) (i)20236306 (c) 20236 30202212 31 20236306 30120 20236 30202212315%5% (a) (b)2023630 (i)202363020221231 20236306 (3) (c) (ii)2023630 120121 20236306 (b)2023630 20236306 (5)(a) (b) (i)2023630 2023630 2023630 (ii)20221231 20221231 20236306 (d)2023630 20236306 20236306 Kintara Therapeutics, IncKintara12,592KintaraKintara5,623,983 2023630KintaraKintara366,679 20236306 202363029.85%30.47% 20236306 2023630623,890,9742022630623,345,0835,978,6571,9437,407,9861,056,6169,445,77220226 3068,487,93640,6517,225,6361,111,9666,487,894 662,19920226306 202363020221231 20236306 20236306 20236306118,590,85320226 306106,844,837117,953,59320226 306102,559,780637,26020226 3064,285,057202363019% (2022123121%) 20236306 20152015930 (17) 111 20236306 202320242026202720282029203020312032 20236306 20236 30202212315%5% 20236306 20236306