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Series onTesting and Assessment OECD Series on Testing and Assessment Guidance Document for In Vitro Testing ofthe Intestinal Fate of Orally IngestedNanomaterials This work was approved and declassified by the Chemicals and Biotechnology Committee on 22/06/2026. Please cite this publication as: OECD (2026),Guidance Document for In Vitro Testing of the Intestinal Fate of Orally Ingested Nanomaterials, OECD Series onTesting and Assessment, OECD Publishing, Paris,https://doi.org/10.1787/be2a4b9e-en; Photo credits: Egorov Artem/Shutterstock.com © OECD 2026 Attribution 4.0 International (CC BY 4.0) This work is made available under the Creative Commons Attribution 4.0 International licence. By using this work, you accept to be bound by the terms of this licence(https://creativecommons.org/licenses/by/4.0/). Attribution–you must cite the work. Translations–you must cite the original work, identify changes to the original and add the following text:In the event of any discrepancy between the original work and thetranslation, only the text of original work should be considered valid. Adaptations–you must cite the original work and add the following text:This is an adaptation of an original work by the OECD. The opinions expressed and arguments employedin this adaptation should not be reported as representing the official views of the OECD or of its Member countries. Third-party material–the licence does not apply to third-party material in the work. If using such material, you are responsible for obtaining permission from the third party andfor any claims of infringement. Any dispute arising under this licence shall be settled by arbitration in accordance with the Permanent Court of Arbitration (PCA) Arbitration Rules 2012. The seat of arbitrationshall be Paris (France). The number of arbitrators shall be one. About the OECD TheOrganisation for Economic Co-operation and Development(OECD)is an intergovernmentalorganisation in which representatives of 38 countries in North and South America, Europe and the Asiaand Pacific region, as well as the European Union, meet to co-ordinate and harmonise policies, discussissues of mutual concern, and work together to respond to international problems. Most of the OECD’swork is carried out by more than 200 specialised committees and working groups composed of membercountrydelegates.Observers from several Partner countries and from interested internationalorganisations attend many of the OECD’s workshops and other meetings. Committees and working groupsare served by the OECD Secretariat, located in Paris, France, which is organised into directorates anddivisions. The Environment, Health and Safety Division publishes free-of-charge documents in twelve differentseries:Testing and Assessment;Good Laboratory Practice and Compliance Monitoring;Pesticides;Biocides;Risk Management;Harmonisation of Regulatory Oversight in Biotechnology;Safety ofNovel Foods and Feeds; Chemical Accidents; Pollutant Release and Transfer Registers; EmissionScenario Documents; Safety of Manufactured Nanomaterials;andAdverse Outcome Pathways.More information about the Environment, Health and Safety Programme and EHS publications is availableon the OECD’s World Wide Web site (https://www.oecd.org/en/topics/chemical-safety-and-biosafety.html). This publication was developed in the IOMC context. The contents do not necessarilyreflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organisation Programme for the Sound Management of Chemicals (IOMC)was established in 1995 following recommendations made by the 1992 UN Conferenceon Environment and Development to strengthen co-operation and increase internationalco-ordination in the field of chemical safety. The Participating Organisations are FAO,ILO,UNDP,UNEP,UNIDO,UNITAR,WHO,World Bank,Basel,Rotterdam andStockholm Conventions and OECD. The purpose of the IOMC is to promote co-ordinationof the policies and activities pursued by the Participating Organisations, jointly orseparately, to achieve the sound management of chemicals in relation to human healthand the environment. Acknowledgements The following Italian experts contributed to the drafting of this Guidance Document: Maria Alessandrelli( Italian National Institute of Health/Italian Ministry of Health ,REACH/CLP CompetentAuthority); Cristina Andreoli (Italian National Institute of Health); Chiara Laura Battistelli (Italian NationalInstitute of Health); Federico Benetti (EcamRicert);Fabio Boccuni (Italian Workers’ CompensationAuthority, INAIL); Isabella De Angelis (formerly Italian National Institute of Health); Etienne Mantovan(EcamRicert); Valentina Prota (Italian National Institute of Health); Stefania Sabella (Italian Institute ofTechnology); Olimpia Vincentini (Italian National Institute of Health); Michela Zanella (EcamRicert). We would like to thank for the fruitful comments from the Heads of the OECD WPMN Italian Delegation,Cecilia Bossa and F