Up to $1,000,000,000 of Class A Common Stock On December 17, 2025, Healthcare Realty Trust Incorporated (the “Company” or “HR”) and Healthcare Realty Holdings, L.P. enteredinto equity distribution agreements (as amended from time to time, the “equity distribution agreements”) with each of J.P. MorganSecurities LLC, BofA Securities, Inc., Barclays Capital Inc., BTIG, LLC, Citigroup Global Markets Inc., Credit Agricole Securities(USA) Inc., Fifth Third Securities, Inc., Jefferies LLC, Mizuho Securities USA LLC, Morgan Stanley & Co. LLC, MUFG SecuritiesAmericas Inc., RBC Capital Markets, LLC, Regions Securities LLC, Scotia Capital (USA) Inc., Truist Securities, Inc., and WellsFargo Securities, LLC, as sales agents (each a “sales agent,” and together, the “sales agents”), and each of the forward sellers andforward purchasers (as defined below), to offer and sell up to an aggregate of $1,000,000,000 of the Company’s Class A CommonStock, par value $0.01 per share, which we refer to herein as our common stock, from time to time through the sales agents. The equity distribution agreements provide that, in addition to the issuance and sale of shares of common stock by us through the salesagentsacting as our sales agents or as principals, we also may enter into forward sale agreements under separate master forward saleagreements and related supplemental confirmations between us and each of JPMorgan Chase Bank, National Association, Bank ofAmerica, N.A., Barclays Bank PLC, Citibank, N.A., Crédit Agricole Corporate and Investment Bank, Jefferies LLC, Mizuho MarketsAmericas LLC, Morgan Stanley & Co. LLC, MUFG Securities EMEA plc, Nomura Global Financial Products, Inc., RegionsSecurities LLC, Royal Bank of Canada, The Bank of Nova Scotia, Truist Bank, and Wells Fargo Bank, National Association. We referto these entities, when acting in this capacity, individually as a “forward purchaser” and collectively as “forward purchasers.” We referto the sales agents,or their applicable affiliates or, in the case of BTIG, LLC, Nomura Securities International, Inc. (acting throughBTIG, LLC as agent), when acting as agents for the forward purchasers, individually as a “forward seller” and collectively as “forwardsellers.” Each forward purchaser will be either one of the sales agents named herein or an affiliate of one of those sales agents and,unless otherwise expressly stated or the context otherwise requires, references herein to the “related” or “relevant” forward purchasermean, with respect to any sales agent, the affiliate of such sales agent that is acting as forward purchaser or, if applicable, such salesagent acting in its capacity as forward purchaser. In connection with each particular forward sale agreement, the relevant forwardpurchaser will, at our request, borrow from third parties and, through the relevant forward seller, sell a number of shares of ourcommon stock equal to the number of shares of common stock underlying the particular forward sale agreement. In no event will theaggregate offering price of shares of common stock sold through the sales agents and forward sellers under the equity distributionagreements and under any forward sale agreements exceed $1,000,000,000.As of the date of this prospectus supplement, we have not sold any shares of our common stock under the equity distribution agreements, and as a result, shares of our common stock having an aggregate price of up to $1,000,000,000 remain available for offerand sale pursuant to this prospectus supplement and accompanying prospectus. Any sales pursuant to this prospectus supplement willbe made in accordance with the equity distribution agreements and related master forward sale agreements. The Company’s common stock trades on the New York Stock Exchange (the “NYSE”) under the symbol “HR.” On July 30, 2026, thelast reported sales price of the Company’s common stock on the NYSE was $21.53 per share. Sales of shares of the Company’s common stock under this prospectus supplement and the accompanying prospectus, if any, may bemade in privately negotiated transactions (including block transactions) and/or any other method permitted by law, including salesdeemed to be an “at the market” offering as defined in Rule 415 under the Securities Act of 1933, as amended (the “Securities Act”),which includes sales made directly on the NYSE, the existing trading market for the Company’s common stock, or sales made to orthrough a market maker other than on an exchange. The sales agents and forward sellers will make all sales on a best efforts basisusing commercially reasonable efforts consistent with their respective normal trading and sales practices, on mutually agreed termsbetween the sales agents or forward sellers and the Company. There is no specific date on which the offering will end, there are nominimum purchase requirements and there are no arrangements to place the proceeds of the offering in an escrow, trust or similaraccount. Under the terms of the e