Common Stock We have entered into a sales agreement (the “Sales Agreement”) with TD Securities (USA) LLC (“TD Cowen”),dated May22, 2026, relating to the sale of shares of our common stock, par value $0.0001 per share (“CommonStock”), offered by this prospectus supplement and the accompanying prospectus. In accordance with the termsof the Sales Agreement, we may offer and sell shares of our Common Stock having an aggregate offering price of Our Common Stock is listed on The Nasdaq Global Market (“Nasdaq”) under the symbol “AVR.” Our CHESSDepositary Interests over our Common Stock (“CDIs”) trade on the Australian Securities Exchange (“ASX”)under the symbol “AVR.” On May21, 2026, the last reported sale price of our Common Stock on Nasdaq was Sales of our Common Stock, if any, under this prospectus supplement and the accompanying prospectus will bemade in negotiated transactions, including block trades or block sales, or by any method permitted by lawdeemed to be an “at the market offering” as defined in Rule415 promulgated under the Securities Act of 1933, asamended (the “Securities Act”), including without limitation sales made through Nasdaq or on any other tradingmarket for our Common Stock, or by any other method permitted by law. TD Cowen is not required to sell anyspecific amount of securities, but will act as our sales agent using commercially reasonable efforts consistent with The compensation to TD Cowen for sales of Common Stock sold pursuant to the Sales Agreement will be anamount equal to 3.0% of the gross proceeds of any shares of Common Stock sold under the Sales Agreement. Inconnection with the sale of the Common Stock on our behalf, TD Cowen may be deemed to be an “underwriter”within the meaning of the Securities Act and the compensation of TD Cowen may be deemed to be underwriting Investing in our Common Stock involves a high degree of risk. You should read carefully and consider therisks referenced under the section titled “Risk Factors” beginning on page S-5 of this prospectus Neither the Securities and Exchange Commission nor any state securities commission has approved ordisapproved of these securities or passed upon the accuracy or adequacy of this prospectus supplement or Prospectus Supplement TABLE OF CONTENTS ABOUT THIS PROSPECTUS SUPPLEMENT This prospectus supplement relates to the offering of shares of our Common Stock having an aggregate offeringprice of up to $250,000,000 from time to time pursuant to the Sales Agreement with TD Cowen and adds to andupdates information contained in the accompanying prospectus. The accompanying prospectus provides moregeneral information, some of which may not apply to this offering. Generally, when we refer to this prospectus, we This prospectus forms a part of a registration statement on FormS-3 that we have filed with the Securities andExchange Commission (the “SEC”) utilizing a “shelf” registration process. You should read this prospectus and therelated exhibits filed with the SEC, together with the additional information described under the headings “Where We have not, and TD Cowen has not, authorized anyone to provide you with any information other than theinformation contained or incorporated by reference in this prospectus supplement or the accompanying prospectus orany free writing prospectus prepared by or on behalf of us in connection with this offering to which we have referredyou. We and TD Cowen take no responsibility for, and can provide no assurances as to the reliability of, any otherinformation that others may give you. The information contained in this prospectus supplement or the accompanyingprospectus, or incorporated by reference herein or therein, or in any such free writing prospectus provided inconnection with this offering is accurate only as of the date thereof, regardless of the time of delivery of such Information contained on, or accessible through, our website is not part of this prospectus supplement. Neitherwe nor TD Cowen are offering to sell, or seeking offers to buy, our Common Stock in any jurisdictions where offersand sales are not permitted. The distribution of this prospectus supplement and the accompanying prospectus and theoffering of our Common Stock in certain jurisdictions may be restricted by law. Persons outside the United Stateswho come into possession of this prospectus supplement and the accompanying prospectus must inform themselvesabout, and observe any restrictions relating to, the offering of our Common Stock and the distribution of this In this prospectus supplement, unless otherwise indicated or the context otherwise requires, all references inthis prospectus to the “Company,” “Anteris,” “Anteris®,” “we,” “us” and “our” refer to Anteris Technologies Pty Ltd(formerly Anteris Technologies Ltd) (“ATPL”) prior to the Reorganization (as defined herein) and Anteris TABLE OF CONTENTS PROSPECTUS SUPPLEMENT SUMMARY This summary highlights selected information, some of which is presented