世界卫生组织妊娠期体重增加技术咨询小组第五次会议报告

theFifthMeetingofthe WHOTechnicalAdvisory Group on 24November2025 Reporton TheFifthMeeting of theWHOTechnicalAdvisory 24November2025 CONTENTS ACRONYMS.................................................................................................................................41.INTRODUCTION...................................................................................................................52.SUMMARY OF DAY 1 PRESENTATIONS AND DISCUSSIONS.....................................................6Session 1: Updates on the GWGdatabase................................................................................6Session 2: Definition of initial weight.........................................................................................9Session 3: Outliers’ assessment.............................................................................................14Session 4: Descriptive database.............................................................................................18 ReportontheFifthMeetingof theWHOTechnicalAdvisoryGrouponGestationalWeightGain ACRONYMS ANCAntenatal careBMIBodymassindexcmCentimetreGWGGestational weight gainkgKilogram ReportontheFifthMeetingof theWHOTechnicalAdvisoryGrouponGestationalWeightGain 1.INTRODUCTION Pregnancy is a unique period in the life cycle for implementing interventions to optimize longer-term maternal and child health. Pregnant women’s frequent contact with the health care system There is a lack of evidence-based public health tools for monitoring gestational weight gain (GWG)that apply to women of all body mass index (BMI) categories and geographic locations. The GWGrecommendations used worldwide and endorsed by the World HealthOrganization (WHO) in the To address this critical gap, WHO initiated a normative process to develop global GWG standardsthat can be used as a tool for dynamic monitoring during ANC in a diverse range of settings. Animportant outcome of this project will also be the definition ofrecommended GWG ranges based This project is led by the WHO Departments of Nutrition and Food Safety (NFS) and Sexual andReproductive Health and Research (SRH), with contributions of the Department of Maternal,Newborn, Child and Adolescent Health and Ageing, in partnership with scientists from the FederalUniversity of Rio de Janeiro (Brazil), Cornell University (USA), and the University of British Columbia The TAG-GWG's focus is to advise on the development of the GWG charts and optimal ranges. Thisincludes providing advice on the development of a detailed research protocol,encompassingthedefinition of study-and individual-level eligibility criteria to determine a sample that is asprescriptive as data and evidence allow. The advice will also include the methods and approaches The Fifth Meeting of the WHO TAG-GWG was convened virtuallyon24 November 2025. Theobjectives of the meeting were to present and discuss: 1)Updates on the GWG database, including the final list of included studies and theweighting methods2)Decisions on the initial weight used to calculate BMI and GWG3)Results on the outliers’ assessment Thisreportprovides asummaryofdiscussions and recommendations emanating from thismeeting. A list of participants and the meeting agenda are available inAnnexes IandII. 2.SUMMARYOFDAY 1PRESENTATIONS AND DISCUSSIONS Elaine Borghi,WHO/NFS,opened the meeting and thankedthe TAG-GWG working groups for theirwork since the previous meeting.She introducedthe meetingchair,Helena Teede.AllTAG-GWGadviserswereasked to declare any conflicts of interest;nonewere declared. Session 1:Updates on the GWGdatabase Giovanna Gatica-DomínguezandRichard Kumapleypresented an overview of thestudiesincludedin the GWG databaseand the weightingproposed for the final sample. Approximately 50 studies were initially included in the database, however, a total of 20 studiesfrom nine countrieswere excludedfor a variety of reasons, including: (1)Ahigh prevalence of pre-eclampsia (one multi-country studyexcluded)(2)More than 30percentmissing values for initial weight (11 studiesexcluded)(3)Ethical constraints (two studiesexcluded)(4)Data sharing agreements not signed (four studiesexcluded)(5)Data was not shared in time (two studiesexcluded) Theremaining30 studies come from 26 countries across all seven WHO regions(Table 1). The final sample includes over 370,000 pregnancies.The proportion of thefinalsample waspresented by country and BMI category.Notably, 71percentof the sample comes from Sweden(Table 2).Stratified by pre-pregnancy BMI category, approximately 5.5percentof the samplehad Different classification strata are being investigated tomake the sample more representativeacross contexts, including the Global Burden of Disease(GBD)super regions.Figure 1shows thedistribution of the sample population across the seven GBDsuperregions compared to thereference population (the estimatednumber of pregnantwomenin each region2). There is a highnumber of high-i