Inspira Technologies Oxy B.H.N. Ltd American Stock Prospectus (Version 2026-02-17)

Up to $2,015,985Ordinary Shares We have entered into a sales agreement (the “Sales Agreement”) with A.G.P./Alliance Global Partners (“A.G.P.” or the “SalesAgent”), dated February 17, 2026, relating to the sale of our ordinary shares, no par value (“Ordinary Shares”), offered by thisprospectus supplement and the accompanying prospectus. In accordance with the terms of the Sales Agreement, we may offer and sell Sales of our Ordinary Shares, if any, under this prospectus supplement may be made in sales deemed to be “at the marketofferings” as defined in Rule 415 promulgated under the Securities Act of 1933, as amended (the “Securities Act”). A.G.P. is notrequired to sell any specific number or dollar amount of securities, but will act as a sales agent using commercially reasonable efforts A.G.P. will be entitled to compensation at a commission rate of 3.0% of the gross sales price per share sold pursuant to theterms of the Sales Agreement. See “Plan of Distribution” beginning on page S-12 for additional information regarding thecompensation to be paid to A.G.P. in connection with the sale of the Ordinary Shares on our behalf, A.G.P. will be deemed to be an“underwriter” within the meaning of the Securities Act, and the compensation of A.G.P. will be deemed to be underwriting The Ordinary Shares are listed on the Nasdaq Capital Market under the symbol “IINN.” On February 13, 2026, the lastreported sale price of the Ordinary Shares on the Nasdaq Capital Market was $0.589 per share. The aggregate market value of our outstanding Ordinary Shares held by non-affiliates was approximately $40,465,439 basedon 39,671,999 shares of outstanding Ordinary Shares held by non-affiliates and a price per share of $1.02, the closing price of ourOrdinary Shares on December 19, 2025. Pursuant to General Instruction I.B.5 of Form F-3, we may not sell securities registered onForm F-3 with a value more than one-third of the aggregate market value of our Ordinary Shares held by non-affiliates in any 12- We are an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012, and have elected tocomply with certain reduced public company reporting requirements. Investing in the Ordinary Shares involves risk. See “Risk Factors” beginning on page S-4 of this prospectussupplement and in the documents incorporated by reference into this prospectus supplement and the accompanying Neither the Securities and Exchange Commission nor any state or other foreign securities commission has approved ordisapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to thecontrary is a criminal offense. A.G.P. The date of this prospectus supplement is February 17, 2026 TABLE OF CONTENTS Prospectus Supplement Table of Contents ABOUT THIS PROSPECTUS SUPPLEMENT This prospectus relates to part of a registration statement on Form F-3 that we have filed with the Securities and ExchangeCommission (the “SEC”) utilizing a “shelf” registration process. Under this shelf registration process, we may sell the securitiesdescribed in our base prospectus included in the shelf registration statement in one or more offerings up to a total aggregate offering This document contains two parts. The first part is this prospectus supplement, which describes the terms of this offering ofthe Ordinary Shares, and also adds, updates and changes information contained in the accompanying prospectus and the documentsincorporated herein and therein by reference. This prospectus supplement relates only to an offering of up to $2,015,987 of ourOrdinary Shares through A.G.P. These sales, if any, will be made pursuant to the terms of the Sales Agreement, entered into betweenus and A.G.P. on February 17, 2026, a copy of which will be incorporated by reference into this prospectus supplement. The secondpart is the accompanying prospectus, which gives more general information about us, some of which may not apply to this offering.You should read both this prospectus supplement and the accompanying prospectus, including the information incorporated byreference herein and therein. To the extent the information contained in this prospectus supplement differs or varies from theinformation contained in the accompanying prospectus or any document filed prior to the date of this prospectus supplement andincorporated herein or therein by reference, the information in this prospectus supplement will control; provided, that if any statement You should rely only on the information contained in or incorporated by reference into this prospectus supplement and theaccompanying prospectus. We have not authorized anyone to provide you with information that is different. No dealer, salesperson orother person is authorized to give any information or to represent anything not contained in or incorporated by reference into thisprospectus supplement and the accompanying prospectus, and you must not rely upon any info