2025年粮农组织-世界卫生组织农药残留联合会议（JMPR）总结报告

Summary report of the2025JointFAO/WHOMeeting on Pesticide Residues(JMPR) Acceptabledailyintakes,acutereferencedoses,residuedefinitions,recommendedmaximumresiduelevels,supervisedtrialsmedian residue and highest residue values, andgeneral consideration items Geneva,Switzerland,20–22 January 2026 Contents Abbreviations..........................................................................................................................................................iiSummary and recommendations...........................................................................................................................1General considerations.........................................................................................................................................291. Updates on upcoming dietary risk assessment activities.............................................................................292. Integration of data from new approach methodologies (NAMs) into JMPR’s pesticide safety assessments..........................................................................................................................................................................293. Non-linear toxicokinetics guidance electronic working group.....................................................................304. Plasma and/or blood area under the concentration–time curve (AUC) ratio use for identification of majorrat metabolites.................................................................................................................................................315. Update on the Guidance Document for WHO Monographers and Reviewers............................................316. Transition of maximum residue recommendations for meat according to the new Codex Classification for Tables 1. Recommendations made by the 2025 JMPR......................................................................................................22. Previous and current health-based guidance values (HBGVs) for phosmet.....................................................343. Screening inputs and acute intake estimates for withdrawn Codex maximum residuelimits (CXLs) (only thosewhich exceed 100 percent of acute reference dose [ARfD])................................................................................35 Abbreviations ADIacceptable daily intakearasreceivedARfDacute reference doseCCNCodex classification numberCCPRCodex Committee on Pesticide ResiduesCIFOCOssChronic individual food consumption database–SummarystatisticsCXLCodex MRLsdwdryweightFAOFood and Agriculture Organization of the United NationsGAPgood agricultural practiceGECDEglobal estimate of chronic dietaryintakeHBGVhealth-based guidance valueHRhighest residueHR-Phighest residue in a processed commodity (inmg/kg; calculated by multiplying the HR in theraw commodity by the processing factor)HRPhighest reliable percentileIEDIinternational estimated daily intakeIESTIinternational estimate of short-term intakeJMPRJoint FAO/WHO Meeting on Pesticide ResiduesMRLmaximum residue limit Units bwbody weightggram(s)kgkilogram(s)mgmilligram(s) Summary and recommendations The following extracts of theresults of the2025Joint FAO/WHO Meeting on Pesticide Residues (JMPR)are provided to make them accessible to interested parties at an early date. Themeetingevaluated38pesticides,estimatingmaximum residue levels, which it recommended for useas maximum residue limits (MRLs) by theCodex Committee on Pesticide Residues (CCPR). It alsoestimatedlevels ofsupervised trials median residue (STMR) and highest residue (HR) as a basis forestimation of the dietaryintake of pesticideresidues.The meeting also established new acceptable daily Table 1 includes the Codex classification numbers (CCNs) of the commodities to facilitate reference to theCodex maximum limits for pesticide residues (Codex Alimentarius, Volume2B) and other documents of Apartfromtheabbreviationspresented in the section, Abbreviations (p. iii),thefollowingqualificationsare •*:at or about the limit of quantification;•**:compound evaluated under the periodic review program;•***:new compound; and •a:for monitoring and regulatory purposes, whole milk is to beanalysed, and the result compared to theMRL for whole milk. General considerations 1.Updates on upcoming dietary risk assessment activities The meeting received a range of documents summarizing a number of issuesrelatedto the dietary riskassessment methodologies being developed by the JMPR. These documents included the draft report ofthe 56th Session of the Codex Committee on Pesticide Residues (CCPR56) (FAO and WHO, 2025a) and The meeting was informed by the Joint Secretariat that anad hocmeeting will be convened to addressand develop, to the extent possible before the next JMPR, methodologies that are updated and adequatefor the dietary risk assessment of compounds evaluated by the JMPR. The meeting recommends thatparticipants to thismeeting include