Healthcare MosaicAdvanced Specialty Care Update:As Acuity and Cost of Care Elevate, Please refer to important disclosures on pages 61 and 62. Analyst certification is on page 61.William Blair or an affiliate does and seeks to do business with companies covered in its research reports. As aresult, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of thisreport. This report is not intended to provide personal investment advice. The opinions and recommendations here- Summary............................................................................................................................3Introduction.......................................................................................................................4CMS’s TEAM and Data-Sharing Initiatives Could Serve as Catalysts...............................10Why the Increased Focus on Specialty Care?.................................................................13Key Areas of Advanced Specialty Care............................................................................18Top Disease States for Advanced Specialty Care Management Solutions.....................20Cardiology.....................................................................................................................20 In our quarterlyHealthcare Mosaicreport, we select a far-reaching topic of interest in the health-care space and provide a variety of data points and analyses to offer a more complete picture ofwhat it means for the broader healthcare marketplace—as well as for both public and private In thisHealthcare Mosaic(now our 38thin the quarterly series),we dive back into the growingimportance of advanced specialty care in the value-based care (VBC) market, a topic we first ad-dressed in our September 2023 report on the same topic. •Why the VBC movement requires continued progression toward advanced specialty caremanagement, especially as elevated costs trends and advanced disease progression pressures •The key areas of focus for advanced specialty care—including our updated analyses of the ad-dressable markets, existing risk-based programs, and key savings opportunities for each area; •Key market- and regulatory-driven factors that continue to drive growth in advanced specialtycare—including novel data-sharing requirements and the upcoming launch of CMS’s manda- •Challenges and opportunities in the movement toward advanced specialty care delivery; and •An overview of select companies in both the public and private markets that we believe are Our covered companies that we believe will be most impacted by these trends include the follow-ing:agilon health (AGL), Astrana Health (ASTH), Evolent Health (EVH), Hinge Health (HNGE), P3 Health Partners (PIII), andPrivia Health (PRVA). We also see a number of emerging entities in the space, including operators (categorized by spe-cialty) such as: •Kidney care:Duo Health, Evergreen Nephrology, Healthmap Solutions, Interwell Health,Monogram Health, Nephrology Specialist IPA, Panoramic Health, Somatus, and Strive Health. •Musculoskeletal (MSK):Health Plus Management, Hinge Health, HOPCo (Healthcare Out-comes Performance Company), Icon Health, Limber Health (now part of Net Health), LivaraHealth, Luna Physical Therapy, Kaia Health, Omada Health (OMDA), Protera Health, Recov-eryOne, Regenexx Corporate Program, RightMove Health, Sword Health, TailorCare, United •Oncology and advanced care planning:Aledade, American Oncology Network (AONC), Day-mark Health, Evolent Health, Flatiron Health, Florida Cancer Specialists, GenesisCare, Navista,OncoHealth, OneOncology, The Oncology Institute, The US Oncology Network, Thyme Care,and Verdi Oncology. •Cardiology:Atria Health, CardioOne, Cardiovascular Associates of America, CardiovascularLogistics,Heartbeat Health, Heart & Vascular Partners, Karoo Health, Novocardia (division ofCVAUSA), Nevada Heart and Vascular, US Health Partners, US Heart and Vascular. •Gastroenterology (GI):Ayble Health, Ciba Health, Cylinder Health (formerly Vivante Health),Gastro Health, GI Alliance, Iterative Health, OneGI, Oshi Health, SonarMD, and United Digestive. In addition to these category-specific providers, we also see significant opportunities in the fol-lowing areas: •Virtual specialty care consultations—e.g., DispatchHealth, Ellipsis Health, Included Health,MedArrive, Memora Health (part of Commure), Pager Health, PicassoMD, Quantum Health,RubiconMD (part of CVS Health’s Oak Street Health division), Story Health, and Transcarent. •Third-party VBC measurement and performance analytics providers—e.g., Aidoc, Arca-dia Solutions, Arbital Health, Clarify Health, Innovaccer, MayaMD, Navina, Navvis (a SurroundCare Company), and Wakely (part of HMA); and •Creators ofCenters of Excellence Networks—e.g., Carrum Health, Edison Healthcare, andLantern (fka Employer Direct Healthcare). We profile companies in these areas at the end of our report