Scienture Holdings Inc美股招股说明书(2025-10-24版)

Scienture Holdings, Inc.Common Stock This prospectus supplement (“Prospectus Supplement No. 1”) amends and supplements the information in the prospectus supplementdated September 19, 2025, filed with the Securities and Exchange Commission as part of our registration statement on Form S-3, FileNo. 333-289198 (the “Prospectus Supplement”). This Amendment No. 1 should be read in conjunction with the ProspectusSupplement and the accompanying prospectus dated August 8, 2025 (the “Prospectus”), each of which are to be delivered with thisAmendment No. 1, as well as any of our SEC filings which amend and update this Prospectus Supplement. We are filing this Prospectus Supplement No. 1 solely to increase the amount of shares of our common stock, par value $0.00001 pershare (the “Common Stock”), that we are eligible to sell under General Instruction I.B.6 of Form S-3 and pursuant to the equitydistribution agreement (the “Sales Agreement”) with Maxim Group LLC (the “Sales Agent”), dated September 19, 2025, to anaggregate offering price of up to $9,592,009. This Prospectus Supplement No. 1 is registering the offer and sale of up to $9,592,009 ingross proceeds of our shares of Common Stock from time to time through the Sales Agent, acting as agent. This ProspectusSupplement No. 1 is not complete without and may only be delivered or utilized in connection with the Prospectus Supplement, theProspectus, and any future amendments or supplements thereto. Our shares of Common Stock are traded on the Capital Market tier of The Nasdaq Stock Market LLC (“Nasdaq”) under the symbol“SCNX”. On October 23, 2025, the last reported per share sale price of our shares of Common Stock on Nasdaq was $2.60 per share. The aggregate market value of the outstanding shares of our Common Stock held by non-affiliates pursuant to General InstructionI.B.6 of Form S-3 was approximately $68,601,377, which was calculated based on 34,474,230 shares of Common Stock outstandingas of October 23, 2025, of which 8,089,085 shares of Common Stock were held by affiliates, and a price of $2.60 per share, which wasthe closing price of our shares of Common Stock on Nasdaq on October 23, 2025. Pursuant to General Instruction I.B.6 of Form S-3,in no event will we sell securities in a public primary offering with a value exceeding more than one-third of our public float in any12-month period so long as our public float remains below $75,000,000. We have sold approximately $13,252,250 in gross proceedsof securities pursuant to General Instruction I.B.6 of Form S-3 during the 12 calendar months prior to and including the date of thisProspectus Supplement No. 1, and therefore $9,592,009 remains available to be sold pursuant to this Prospectus Supplement No. 1 andthe Sales Agreement. Investing in our securities involves a high degree of risk. You should read this prospectus supplement dated October 24, 2025and the accompanying prospectus carefully before you make your investment decision. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of thesesecurities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminaloffense. MAXIM GROUP LLC The date of this Prospectus Supplement No. 1 is October 24, 2025.