MIRXES-B中期报告2025

:2629 2-56-78-1819-282930-3132-343536-52 BC-1BC-1RT-qPCRmiRNA CE-IVD(IVDR 2017/746)IVD cGMP FDA LUNGClearTMmiRNAmiRNA RTqPCR RNA RT-qPCR SARS 571 108 TSUI Sin Lai Judy •••1151509 2920 89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands 2 Tukang Innovation Grove#09-02 JTC MedTech HubSingapore 618305 Ogier Global (Cayman) Limited89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands 1982126 33191920 183171712–1716 1 2629 www.mirxes.com 12 Marina BoulevardMarina Bay Financial Centre Tower 3Singapore 018982 25 2014miRNA2025630GASTROClearTMLUNGClearTM FortitudeTMGASTROClearTM12miRNAmiRNAGASTROClearTM20195HSACIVD 2025630GASTROClearTM LUNGClearTM50%10.520249.69.4%10.520242.6COVID-19FortitudeTM7.120243.5102.9%20244.751.1%7.149.0%67.6% GASTROClearTMIVDGASTROClearTM12miRNAmiRNAGASTROClearTM20195HSAC IVD201711CE-IVDGASTROClearTM20235FDAmiRNAFDAGASTROClearTM2019LDT202210GASTROClearTMGASTROClearTMmiRNA656miRNA LUNGClearTM GASTROClearTMLUNGClearTM1,688miRNALUNGClearTMmiRNALDCTLDCTLUNGClearTMLDCTLUNGClearTM20221220231LUNGClearTMLDT CRC-1 CRC-1miRNACRC-120252025CRC-1LDTCRC-1IVD20262026IVD LV-1 LV-1miRNALV-12025630202122,0002026 BC-1 BC-1RT-qPCRmiRNABC-120256302026 CADENCE CADENCE20,000miRNADNACADENCE2027 PHinder PHinderActelionPharmaceuticalsmiRNAPHindermiRNAmiRNANT-proBNPmiRNA2025PHinderIVDPHinderIVD2025PHinderLDTPHinder HF-1 HF-1miRNAmiRNAmiRNAmiRNA2026 FortitudeTM FortitudeTMRT-qPCRCOVID-19SARS-CoV-2FortitudeTM2.020204IVD20206CE-IVDCOVID-19 RT-qPCRCOVID-19 18A.08(3)GASTROClearTMLUNGClearTMIVD miRNAmiRNAmiRNA2025630— 202563019276320256301718 20 cGMP590,695miRNAmiRNAmiRNA GASTROClearTMFortitudeTM LUNGClearTMGASTROClearTM20195HSAC IVD201711CE-IVDFortitudeTM 2.020204HSA20206CE-IVDFortitudeTM20221220231LUNGClearTMLDT MiRXES 2025 GASTROClear™miRNA qPCR oCLDTLDToIIIIIICE-IVDoLDT LUNGClear™miRNA qPCR oLDToIVD CRC-1miRNA qPCR ooCIIIoIVDLDT 2025630 2024630 10.520249.69.4%GASTROClearTM LUNGClearTMFortitudeTM2.6 10.520247.050%GASTROClearTM LUNGClearTM COVID-1920242.6 20244.465.9%7.320245.238.5%3.2 3.420244.930.6% 7.120244.751.1%7.120243.5102.9% 202463049.0%18.667.6% 8.820243.3 6.320247.010% 9.2202410.714.0% 20.2202421.24.7% 78,0002024 120,000202425,000380.0% 8.420246.823.5%2024 27,000202461,00055.7%20242025 28.2202444.336.3% 2025630129,725,2102024123134,796,409202563033,137,1082024123148,108,811 2025630108.42024123111.1 0.420240.7 202563010.4202412319.3 100%202563029.8%20241231377.8% 20256306.311.72.00%15.00% 2025630 20256305.8 2025630 2025630 2025630 202563034718.9202419.7 2021317202164— D. 13.51B(1) 2025630XV23336 (1)2025630276,342,331 (2)Central Road Holdings LimitedCentral RoadHoldings Limited (3)SLW Gene LimitedSLW Gene Holding LtdSLW Gene Holding LtdFrandor LimitedFrandor LimitedSLWSLW Gene Holding LtdTrident Trust Company (Singapore)Pte. LimitedTridentTridentSLWSLWTridentFrandor LimitedSLW Gene Holding LtdSLW Gene Limited18,660,556 (4)Accurate Gene LimitedAccurate Gene Holding LtdAccurate Gene Holding LtdFrandor LimitedFrandor LimitedAccurate GeneAccurate Gene Holding LtdTridentTridentAccurate GeneAccurate GeneTridentFrandor LimitedAccurate Gene Holding LtdAccurate Gene Limited17,860,556 (5)MSEA Ltd15,160,000Frandor LimitedFrandor LimitedMirxes HoldingMSEA LtdTridentTridentMirxes HoldingMirxes HoldingTridentFrandor LimitedMSEA Ltd 2025630XV23336 2025630XVXV78352 2025630XVXV78352 20213172023721 (i)(ii)(iii) 1,600,000 (1)(i)(ii)50% 2021642023721 (i)(ii)(iii) (a)(b)(i)(ii)(iii) 13,560,00012813,560,000(i)(ii)(iii) (1)(i)(ii)50% (2) 2025630 13.2013.2113.22 2025630 C12025630 C3 2025630 20256302025630 2025523880.5 2025630 (1) 2025630— 2025630— 2025630— 2025630— 1. 2020111789 Nexus Way, Camana Bay, Grand Cayman, KY1-9009, Cayman Islands331919202025523 miRNA 2. 342025825 20251231202551520222023202412313 34 20241231 3. 4. 4. 4. 4. 6. (a) (b) 6. (c) 7. 202442913,197,35010,152,236 17%25% 9. 13 112213 20256302024123132025630320241231 3 202563010%475,79820241231468,096 10. (a) 28,352,272202444,451,768153,080,0452024120,062,653 (b) 20256302024630177 11. 2025630232,7452024630743,64720256301,032,0692024630322,2241,031,201202463064,028 2024123112—15—20256305,765,447202412315,845,813 12. 2025630395,19120246301,067,782 13. 2025630136,09320246302025630202463057,35557,355 14. 6,000,000 17. BCD11 BCD 202411 20241231202511 2025630 18. 19. (a) 202563010,000,000,000202412319,903,537,67239,700,000B37,618,800C19,143,528D 2025630 (b) 2025630 2025630Trident Trust Company (Singapore) Pte. Limited3,045,1142024123113,197,3507 19. (c) (i) (ii) 20241231 2025630 (iii) (iv) (d) 20252024630 20. 202563020241231 ————