百济神州2025中期报告

（根據瑞士法律註冊成立的公司） Cancer has no borders. Neither do we. 2 4 7 28 82 83 87 89 124 128 Margaret Han DuganRanjeev Krishana Anthony C. Hooper3Michael GollerAlessandro RivaShalini Sharp3 Olivier BrandicourtMargaret Han DuganMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. SandersShalini Sharp Alessandro RivaMargaret Han DuganMichael GollerCorazon (Corsee) D. Sanders Anthony C. HooperOlivier BrandicourtMargaret Han DuganRanjeev KrishanaCorazon (Corsee) D. Sanders Shalini Sharp(1)Olivier BrandicourtCorazon (Corsee) D. SandersAnthony C. Hooper2 1.2025312.2025313.2025116 (FCG, HKFCG)Vistra Corporate Services (HK) Limited Homburger AG 183171712-1716 Ernst & Young LLP Ernst & Young AG Computershare Switzerland LtdBaslerstrasse 90, P.O. Box, 4601 Olten BeOne Medicines I GmbHAeschengraben 27, 4051 Basel 06160 www.beonemedicines.com ••••••••••• ••••••••••••••• GAAP GAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAPGAAP ®5BTK3BCL2BTKCDAC BGB-166731820 2025829BCL2(BTK)CD20(MCL)1/2(BGB-11417-201) 2025731EMA(BTK)BGB-16673(PRIME)BTK(WM) 2025728CHMP®(NSCLC) 2025710® 2025626 2025625CHMP®CHMP 2025611® 2025527 3,700CROCRO 1,200202563015MoACDACADC ®® ®30357,000®®BTKCDACCLLBBTK CDAC®CLL3CLL PD-1 PD-1®®®® 202563028202563045%20252025GAAP2025 20256302024630 202463016.808202563024.32644.7%® 202563044.5%24.10616.681®®®®2025630 2025630®17.41554.7%2025630®12.4698.30850.1%®BTK2025630®2.66479.7%®1.64435.8%2025630®6,390147.2% 2025630®3.6473.03720.1% 20256302.4041.620® 202563020246302,2001,280 202563020.81014.05084.2%202563086.3%®®®84.7%86.9% 20246309.1519,17010.0%202563010.06820256302024630 1.20256309,2704,7104,560 2.GAAPGAAP 2025630BCL2 2,1503.7%6.065 1.GAAPGAAP 20246308.7121.26014.5%20256309.972202563041.4%52.2% 20246302,9402,00068.2%2025630930 20256301,21020246301,020 20246302,22020256302,49020256308702024630 202574(H.R. 1)(OBBBA)OBBBAOBBBA 2025630GAAP 20256300.07ADS0.890.850.27ADS3.56 GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAP GAAPGAAP GAAP GAAPGAAP GAAP GAAP GAAP GAAPADS GAAPADSGAAP ADS GAAPADS GAAPADS1GAAP ADS 12024GAAPADSADSADS0.02GAAPGAAP GAAP(GAAP) GAAP 2025630(1)11(2)10014;(3)2.811 202412316.76320256307.70814.0% 202412311.92920256302.80545.4%(i)(ii) 2024123115.784202563016.1582.4% 2024123151.1202563064.927.0% 2025630202412313.6084.05 202563020241231 202412318.03720256309.08913.1%(i)(ii) 2024123110.1820256309.5456.2% 202563020241231 202520246301231 2,786,0862,638,747954,4851,018,013 20241220256309.54520256307,1106.72312 2021121520256303.595 20256302024630 20256307.1183.597 20256301.8853.209 20256301201.853 128.084 2025630650 2025630 20256301.3013,2609,750 128.0841.461202563012 12.520256302.429 2025630670 20256306,200 GAAP 2024123110-K72025630 202563010-Q11. 20256306.1542025630100620 200520256301.9%202412312.8% 202563020246306501,35020256301.289202563010%1,170 2025630 20256302024123130.6%25.3% 2025630 2025630 630 11,00020256301020246309 202563030.02024123111.3158.220241231144.9 20256302024630 2 2025630XV(a)XV78(b)352(c) (1)20256301,539,858,5621,117,3362025521BG NC 2, Ltd133,000,000201617202563021,880,88520255142025522(2)(1)7,158,352(2)14,721,503(3)814,323(4)1,721,174(3)Roth IRA PENSCO(4)The John Oyler Legacy Trust(5)(6)Oyler Investment LLCOyler Investment LLC 99%(7)The Oyler Family Legacy Trust(8)(9)(10)(1)4,910,312(2)5,964,265(3)244,458(11)Wang Investment LLCWang Investment LLC99%(12)(13) (14)(1)Brandicourt16,341(2)BrandicourtBrandicourt84,695(3)Brandicourt10,985 (15)(1)Dugan45,955(2)DuganDugan141,102(3)Dugan10,985 (16)(1)Goller63,037(2)GollerGoller463,437(3)Goller10,985 (17)(1)Hooper24,492(2)HooperHooper203,372(3)Hooper40,248 (18)(1)Krishana63,037(2)KrishanaKrishana463,437(3)Krishana10,985 (19)(1)Riva45,955(2)RivaRiva141,102(3) Riva10,985 (20)(1)Sanders46,241(2)SandersSanders163,501(3) Sanders10,985 (21)(1)SharpSharp39,988(2) Sharp19,136 (22)(1)16,341(2)463,437(3)10,985 2025630(a)XV78(b)352(c) 2025630XV23336 (S) (1)20256301,539,858,5621,117,3362025521BG NC 2, Ltd133,000,000201617202563021,880,88520255142025522 (2)Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLCBaker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.BBAMichael GollerRanjeev KrishanaBBA BakerBrothers Life Sciences Capital,L.P.Baker Bros.Advisors(GP)LLC Julian C.BakerFelixJ.Baker20255272025521104,889,368BakerBrothers Life Sciences,L.P.Julian C.BakerFelixJ.Baker Baker Bros.Advisors(GP)LLCBBA667,L.P.10,289,430BakerBrothersLife Sciences,L.P.104,889,368723,996BBABaker Brothers Life Sciences Capital, L.P.BakerBrothers Life Sciences,L.P.104,889,368723,996BBA JulianC.BakerFelixJ.Baker270,868FBB3LLC144,517 (3)(i)5,725,341CapitalInternational,Inc.(ii)985,896CapitalInternational Limited(iii)1,926,053CapitalInternational Sarl(iv)