非HIV免疫功能低下个体HPV疫苗接种的疗效、有效性、免疫原性和安全性的系统评价和荟萃分析

ECDCASSESSMENT Asystematic review and meta-analysesofthe efficacy, effectiveness,immunogenicity and safety of HPVvaccination in non-HIVimmunocompromised individuals Thisreportwas commissioned by the European Centre for Disease Prevention and Control (ECDC), as part of theactivities of the ECDC NITAG Collaboration, in close cooperation with the European Commission and the EuropeanHealth and Digital Executive Agency. The commissioning and production of this review was coordinated by KateOlsson (ECDC) and Karam Adel Ali (ECDC). Authors Philipp Kapp [Institute for Evidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine,University of Freiburg,Freiburg, Germany];Waldemar Siemens [Institute for Evidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany];Lea Gorenflo [Institute forEvidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg,Germany; Cochrane Germany, Cochrane Germany Foundation, Freiburg, Germany];Henriette Schulz[Institute forEvidence in Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg,Germany];Yuan Chi[Beijing Yealth Technology Co., Ltd, Beijing, China];Irma Klerings[Universität Krems, Krems,Austria];Marianne Röbl-Mathieu[Gynaecologist, Munich, Germany];Mona Askar[Immunization Unit, Robert Koch-Institute, Berlin, Germany];María Brotons [Cancer Epidemiology Research Programme, Catalan Institute ofOncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain;Bellvitge Biomedical Research Institute–IDIBELL.L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health–CIBERESP, Madrid, Spain];Peter Henrik Andersen [Department of Infectious Disease Epidemiology, SSI,Copenhagen, Denmark];Deborah Konopnicki[Saint-Pierre University Hospital, Université Libre de Bruxelles,Brussels, Belgium];Judi Lynch [National Cervical Screening Laboratory, The Coombe Hospital, Dublin, Ireland];Simona Ruţă[Carol Davila University of Medicine and Pharmacy & Stefan S. Nicolau Institute of Virology, Bucharest,Romania];Liisa Saare [Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia];BéatriceSwennen [Public Health School, Université Libre de Bruxelles, Brussels, Belgium];Ruth Tachezy[Faculty of ScienceBIOCEV Charles University, Prague, Czech Republic];Anja Takla[Immunization Unit, Robert Koch-Institute, Berlin,Germany];Veronika Učakar[National Institute of Public Health, Ljubljana, Slovenia];Simopekka Vanska[FinishInstitute for Health and Welfare,Helsinki, Finland];Dace Zavadska[Rīgas Stradiņa Universitāte, Riga, Latvia];Karam Adel Ali[European Centre for Disease Prevention and Control, Stockholm, Sweden];Kate Olsson[EuropeanCentre for Disease Prevention and Control, Stockholm, Sweden];Thomas Harder[Immunization Unit, Robert Koch-Institute, Berlin, Germany];Joerg J Meerpohl[Institutefor Evidence in Medicine, Medical Center-University ofFreiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany]. Stockholm,August 2025 Contents Abbreviations........................................................................................................................................................................ivExecutive summary................................................................................................................................................................1Summary of findings table......................................................................................................................................................41. Background.....................................................................................................................................................................122. Objectives.......................................................................................................................................................................123. Methods..........................................................................................................................................................................134. Results............................................................................................................................................................................185. Discussion.......................................................................................................................................................................386.Conclusions.....................................................................................................................................................................417. References......................................................................................................................................................................42Annex A. Search strategies.....