雅各臣科研制药二零二四/二零二五年年报

: 2633 158 260 461 62 6 763 124 8 125 22 37126 38811232313-18 Conyers Trust Company (Cayman) LimitedCricket SquareHutchins DrivePO Box 2681Grand Cayman KY1-1111Cayman Islands 1617 jacobsonpharma@sprg.com.hk 2633 www.jacobsonpharma.com Cricket SquareHutchins DrivePO Box 2681Grand Cayman KY1-1111Cayman Islands 43.1%300.8 219 7.4%1,576.9 70,000 AI CDCC 20 ArsenolAPL97%100%ArsenolAPL Axicabtagene Ciloleucel (Yikaida)CAR-TATPB (e-Jacob Pharma2U)800 9 SAP • • • 2024J+ Fellow CDCC 7.4%1,576.943.1%300.8 12.7%300.8 EBITDA572.812.2%8.3%509.0 1327 21965136322 20 NCEGERD 23.3%45,600 32330.2250 70,000 ArsenolAPL ArsenolAPL97%100%APL 10 ArsenolEMAODDArsenolpre-IND meetingINDFDAINDSDK TherapeuticsSDK Yikaida(FDA)BCAR-TZUMA-7 Arsenol ArsenolArsenoldossier license agreement ATPCAR-T e-Jacob Pharma2U Arsenol e-JacobPharma2U CAR-T AxicabtageneCiloleucelYikaidaAdvanced Therapeutic ProductATPATP 75%80% YikaidaCAR-TKite Pharma, Inc.FosunKairosFosunKairos 1,280 20%652019 1.8%1.1% CDCC58,000 e-Jacob Pharma2U800 70,000 1,7491,723473.1452.1 109.17.4% 14.7114.0%1.23.6% 36.74.3%43%34%23% 13.93.8% 18.96.8%3.92.0% 81.524.5%414.672.5 37.347.4% 33.812.7%300.890.643.1%56.7 318.6125.230.34.3 18.74.9 1,268.31,157.3 99.3%97.5% 695,540,00098,438,000 *(a)4.1(b) 0.6066,000,0000.010.6139,600,00038,898,0000.59 100%12.2%8.3%588.1 100,500衆 C1 C.2.1C.2.1C.2.1 C.2.1 3.13 AB 3.10(2)3.21 (ii) (iii) (iv) (v) (vi) (vii) (viii) 6 1,000,0003,000,0014,000,0007,000,0018,000,00017,000,00118,000,000 313 2221 2221 14.29%142.25%736 ••••••• (a) (i)(ii)(iii)(iv) (b) (i)(ii)(iii) A.2.1 (1) 5457 I. I. II. 33 III. ••• • • • • • IV. XIVA ••• 4,880,0006,243,0001,642,0002,145,000348,000200,000 58221 www.jacobsonpharma.com/download/Procedures.pdf F.2.2 http://www.jacobsonpharma.comhttp://www.hkex.com.hk (a) (i) (ii) (iii) (iv) (v) (b) www.jacobsonpharma.com 2.07A (c) jacobsonpharma@sprg.com.hk 15 12 http://www.jacobsonpharma.comhttps://www.hkexnews.hk(i)(ii) PIC/S GMPGMP GMPPIC/S 58123 5.503.006.003.5015.005.509 125 23 1,748,875,0001,871,169,0001072461 21 ***^****** *^** 3 3.133.13 13.51B(1) (1)2161 (2)2161(3)(4)1920 6 (A) 62QueenshillKingshillKingshill37 2161 Cardiff UniversityThe Royal Pharmaceutical Society of Great Britain 63Jacobson Pharma Group (BVI) Limited40 2161 1321958781168182687GPI40 University of ManchesterAssociation of Chartered Certified AccountantsChartered Association of Certified Accountants 73 (B) 57The School of Pharmacy, University College London Institute of Child Health, University of LondonGreat Ormond Street Hospital for Children United Kingdom Department of Health Public Health Career Scientist AwardChemist andDruggists Pharmacy Practice Research MedalRoyal College of Paediatrics and Child HealthHonorary Fellowship*Royal Pharmaceutical Society*British Pharmacological Society*Faculty of Public Health, Royal Colleges of Physicians of the United KingdomFellowship Medicines Control AgencyRegulatory AuthorityDavid Lewis Centre for EpilepsyDavid Lewis CentreManchester Medical SchoolUniversity of Bradford Therakind LtdTherakind Ltd (C) 62 (C) 61TGS Global32Hodgson Impey Cheng952878 66 33661559663319201418 6 138,000,0006.90% 301 121% (i)(ii)(iii) 37,000,00037,000,000 3%120.5%120.1% 6,400,0006,000,00020,400,000 (2)21 0.94 Longjin Investments LimitedLongjin 76 (i)(ii)30% KingshillLongjinLongjin30%30% XVXV78352347 (1)31,250,000Queenshill308,404,000Queenshill308,404,000UBS Trustees (B.V.I.) LimitedThe Kingshill TrustUBS NomineesLimitedKingshill Development Group IncTrust CoTrust CoKingshillKingshill850,684,000The Kingshill TrustThe QueenshillTrustThe Kingshill TrustThe Queenshill TrustKingshill850,684,000The Queenshill TrustTheQueenshill TrustThe Queenshill Trust8,200,000The Queenshill TrustThe Queenshill Trust8,200,000 XVXV78352347 XV23336 (1)QueenshillQueenshill308,404,000 (2)UBS Trustees (B.V.I.) LimitedThe Kingshill TrustUBS Nominees LimitedTrust CoTrust CoKingshillKingshill850,684,000The Kingshill TrustThe Queenshill TrustUBS Trustees (B.V.I.) LimitedTrust CoKingshill850,684,000 (3)31,250,000 (4)The Queenshill TrustThe Queenshill TrustThe QueenshillTrust8,200,000The Queenshill TrustTheQueenshill Trust8,200,000 (5)2.06200,000,000200,000,000200,000,000 (6)Longjin75%Longjin157,050,000 (7)696,000 336 Po Chai Herbal Technology LimitedPo Chai HerbalPCHT Herbal SciencesLimitedPCHTPo Chai HerbalPCHT56,50044,000衆46,230,000衆衆(i)59.58%(ii)62.39%Po Chai HerbalPCHTA衆 衆 衆衆218,000(i)59.92%(ii)62.39%衆A 247,000衆 990,0005,580,0005,580,0004,590,000 衆990,000 A (I) (i)(ii)(iii) 10.0% 5,000,0006,000,0007,000,00030 4,554,0004,077,000 (II) (i)(ii)Dr. FreemanDr. Freeman (II) Dr. Freeman 15.0%(i)(ii) (i)(ii)3,500,0003,500,0003,500,0003,000,0004,000,0005,000,00030 5,000,0006,500,000 4,189,0003,390,000209,000112,000 (III) (III) 3,000,0003,500,0004,000,000