Final Report Acknowledgements The team wish to thank the very large number of people who contributed to this review, especially thosewho agreed to be interviewed. Particular thanks are due to Michael Mihut, Christine Coze and AnnabelFrancois for their help in arranging interviews and assembling relevant documents. Table of Contents Glossary............................................................................................................................................iiiExecutive Summary...........................................................................................................................viIntroduction and Background............................................................................................................ 1Evolution of TDR since the sixth review....................................................................................................................1Key achievements over the period (2018-2021).......................................................................................................2VES, IIR and IMP....................................................................................................................................................2RCS........................................................................................................................................................................4Global engagement..............................................................................................................................................5Extent of fit between the TDR’s strategy and structure...........................................................................................7Effects of the COVID-19 pandemic............................................................................................................................8Review Methods............................................................................................................................... 9Background to the Review................................................................................................................12The sixth external review........................................................................................................................................12HRP and AHPSR evaluations....................................................................................................................................12Other reviews..........................................................................................................................................................13Findings...........................................................................................................................................15Relevance................................................................................................................................................................15Effectiveness...........................................................................................................................................................20Efficiency.................................................................................................................................................................31Impact.....................................................................................................................................................................43Sustainability...........................................................................................................................................................51Quality of science....................................................................................................................................................56Crosscutting issues..................................................................................................................................................62Gender and intersectionality..............................................................................................................................62Partnerships........................................................................................................................................................68Climate change...................................................................................................................................................70COVID-19............................................................................................................................................................72Conclusions and Recommendations..................................................................................................77Documents Cited in the Report.........................................................................................................92Annex 1: Terms of Reference.....................................................................