FORM10-K_____________________________________________________________ xANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year endedDecember31, 2024OR oANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _________________ to ___________________ Commission File Number:001-35020_____________________________________________________________ INFUSYSTEM HOLDINGS, INC. (Exact Name of Registrant as Specified in its Charter)_____________________________________________________________ 3851 West Hamlin RoadRochester Hills,Michigan48309(Address of Principal Executive Offices) (Zip Code)Registrant’s Telephone Number, including Area Code:(248)291-1210_____________________________________________________________ Securities Registered Pursuant to Section12(b) of the Act: Securities Registered Pursuant to Section12(g) of the Act:None(Title of Class)_____________________________________________________________ Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.Yes o No x Indicate by check mark if the registrant is not required to file reports pursuant to Section13 or Section15(d) of the Act.Yeso No x Indicate by check mark whether the registrant (1)has filed all reports required to be filed by Section13 or 15(d) of the Securities ExchangeAct of 1934 during the preceding 12 months (or for such shorter periods as the registrant was required to file such reports) and (2)has beensubject to such filing requirements for the past 90days.Yesx No o Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit suchfiles).Yesx No o Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reportingcompany or emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and“emerging growth company” in Rule 12b-2 of the Exchange Act. Large accelerated fileroAccelerated filerxNon-accelerated fileroSmaller reporting companyxEmerging growth companyo If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complyingwith any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.o Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of itsinternal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered publicaccounting firm that prepared or issued its audit report.x If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrantincluded in the filing reflect the correction of an error to previously issued financial statements.o Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).o Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).Yeso No x The aggregate market value of the 20,061,997 shares of voting and non-voting equity of the registrant held by non-affiliates, computed byreference to the $6.83 closing price of the registrant's common stock on June 28, 2024, the last business day of the registrants most recentlycompleted second fiscal quarter, was $137,023,440. Aggregate market value excludes an aggregate of 1,253,049 shares of common stockheld by officers and directors and by each person known by the registrant to own 10% or more of the outstanding common stock on suchdate. This determination of affiliate status is not necessarily a conclusive determination for other purposes. The number of shares of theregistrant’s common stock outstanding as of March9, 2025 was21,009,216. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement to be filed with the Securities and Exchange Commission in connection with thesolicitation of proxies for its 2025 Annual Meeting of Stockholders are incorporated by reference in Part III of this Form 10-K. TABLE OF CONTENTS PART I Item 1.Business3Item1A.Risk Factors9Item 1B.Unresolved Staff Comments20Item 1C.Cybersecurity20Item 2.Properties22Item 3.Legal Proceedings22Item 4.Mine Safety Disclosures22 PART II Item 5.Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of EquitySecurities23Item 6.[Reserved]24Item 7