Structure Therapeutics Inc ADR 2024年度报告

Securities registered pursuant to Section 12(b) of the Act: *Not for trading, but only in connection with the registration of the American Depositary Shares Securities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.Yes☒No☐ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.Yes☐No☒ Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Actof 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subjectto such filing requirements for the past 90 days.Yes☒No☐ Indicate by check mark whether the registrant has submitted electronically; every Interactive Data File required to be submitted pursuant to Rule405 of Regulation S-T (§232.0405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required tosubmit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reportingcompany, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and“emerging growth company” in Rule 12b-2 of the Exchange Act. Large accelerated filer☒Accelerated filer☐Non-accelerated filer☐Smaller reporting company☒Emerging growthcompany☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying withany new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of itsinternal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accountingfirm that prepared or issued its audit report.☒ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrantincluded in the filing reflect the correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to § 240.10D-1(b).☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes☐No☒ The aggregate market value of the registrant’s ordinary shares held by non-affiliates of the registrant as of June 30, 2024, the last businessday of the registrant’s most recently completed second fiscal quarter, was approximately $1,953.6million, based on the closing price of theregistrant’s ordinary shares represented by ADSs on the Nasdaq Global Market of $39.27 per ADS. In determining the market value of the votingequity held by non-affiliates, ordinary shares of the registrant beneficially owned by each director and officer and each person who owns 10% ormore of the registrant’s outstanding ordinary shares have been excluded. This determination of affiliate status is not necessarily a conclusivedetermination for other purposes. The number of outstanding ordinary shares of the registrant, par value $0.0001 per share, as of January 31, 2025 was172,028,543, ofwhich 162,671,754 ordinary shares were held in the form of ADSs. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement for its 2025 Annual General Meeting of Shareholders, which the registrant intends to filepursuant to Regulation 14A with the Securities and Exchange Commission not later than 120 days after the registrant’s fiscal year endedDecember 31, 2024, are incorporated by reference into Part III of this Annual Report on Form 10-K. TABLE OF CONTENTS Part I Item 1.Business6Item 1A.Risk Factors59Item 1B.Unresolved Staff Comments139Item 1C.Cybersecurity139Item 2.Properties140Item 3.Legal Proceedings140Item 4.Mine Safety Disclosures141Part IIItem 5.Market for Registrant’s Common Equity, Related Stockholder Matters andIssuer Purchases of Equity Securities141Item 6.[Reserved]149Item 7.Management’s Discussion and Analysis of Financial Condition and Resultsof Operations150Item 7A.Quantitative and Qualitative Disclosures About Market Risk157Item 8.Financial Statements and Supplementary Data159Item 9.Changes in and Disagreements With Accountants on Accounting andFinancial Disclosure191Item 9A.Controls and Procedures191Item 9B.Other Information193Item 9C.Disclosure Regarding Foreign Jurisdictions that Prevent Inspections193Part IIIIt