Arvinas Holding Co LLC 2024年度报告

Washington, D.C. 20549________________________________________________ (Mark One) ARVINAS, INC. (Exact name of registrant as specified in its Charter)________________________________________________ (Title of class)Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes x No o Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes o No x Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the SecuritiesExchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file suchreports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submittedpursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period thatthe registrant was required to submit such files). Yes x No o Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smallerreporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smallerreporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. Large Accelerated FilerxNon-accelerated filero Accelerated fileroSmaller reporting companyoEmerging growth companyo If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period forcomplying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of theeffectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) bythe registered public accounting firm that prepared or issued its audit report.If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements.□Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to § 240.10D-1(b).□ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YesNo xAs of June 28, 2024, the last business day of the registrant’s most recently completed second fiscal quarter, the aggregate marketvalue of the Common Stock held by non-affiliates of the registrant was approximately $1,796.6 million, based on the closing price ofthe registrant’s Common Stock on such date. The number of shares of registrant’s Common Stock, $0.001 par value per share,outstanding as of February 5, 2025 was 68,771,867. DOCUMENTS INCORPORATED BY REFERENCE Part III of this Annual Report incorporates by reference information from the definitive Proxy Statement for the registrant’s 2025Annual Meeting of Stockholders, which is expected to be filed with the Securities and Exchange Commission not later than 120 daysafter the registrant’s fiscal year ended December 31, 2024. Table of Contents PART I Item 1.Business6Item 1A.Risk Factors78Item 1B.Unresolved Staff Comments127Item 1CCybersecurity127Item 2.Properties128Item 3.Legal Proceedings129Item 4.Mine Safety Disclosures129 PART II Item 5.Market for Registrant’s Common Equity, Related Stockholder Matters and IssuerPurchases of Equity Securities130Item 6.[Reserved]131Item 7.Management’s Discussion and Analysis of Financial Condition and Results ofOperations131Item 7A.Quantitative and Qualitative Disclosures About Market Risk149Item 8.Financial Statements and Supplementary Data149Item 9.Changes in and Disagreements With Accountants on Accounting and FinancialDisclosure149Item 9A.Controls and Procedures149Item 9B.Other Information152Item 9C.Disclosure Regarding Foreign Jurisdictions That Prevent Inspection152 PART III Item 10.Directors, Executive Officers and Corporate Governance 153 Item 11.Executive Compensation153Item 12.Security Ownership of Certain Beneficial Owners and Management and RelatedStockholder Matters153Item 13.Certain Relationships and Related Transactions, and Director Independence153Item 14.Principal Accountant Fees and Services153 PART IV Item 15.Exhibits, Financial Statement Schedules154Item 16.Form 10-K Summary159 CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS AND RISK FACTORSUMMARY Forward-Looking Statements This Annual Report on For