减肥方法及药物的研究进展

WU ZhixunYANG Tian HUANG Yanni LI Qiangxiang Department of Endocrinologythe First Affiliated Hospital of Hunan UniversityHunan Provincial People' s HospitalChangsha 410005China Corresponding authorLI Qiangxiang Email liqiangxiang@ nxmu． edu． cn AbstractObesity is a chronic metabolic diseaseand the prevalence rate is increasing year by year． Obesity isan important risk factor for chronic diseases such as cardio cerebrovascular diseasesdiabetes and various cancers whichhas brought a huge burden to patients' physical and mental health as well as the country's medical care． Now there are avariety of weight loss methods and drugswith different effects and drawbacks． This article briefly reviews the research pro-gress of existing weight loss methods and drugs in order to provide a certain reference for the more reasonable applicationof weight loss methods and drugsand to provide a certain reference for the research and development of weight loss drugs． KeywordsObesityObesity management Bariatric surgery Anti-obesity agentsＲeview 2023SK4054 、6。2、、、7。。2． 14。。、、、、7。3。2． 1． 18-9。《2022》2 000 ～ 2 500 kcal1 kcal = 4． 184 kJ500 ～ 750 kcal。55%～ 65%25% ～ 30%10%～ 15%7。2． 1． 27、、500 ～1 000 kcal13%44%43%。、。2． 1． 310“5 + 2”。“5 + 2”12 d5 d。2 d2 d。2500 ～ 600 kcal2 d。8。9、。、、、、、8。、、、、、、7-810。7。2． 2、、、11。、、。、、11。、、。11150 min75 min2。。11。12。3、“”8。、13、6、14、3。3． 1、、、15。、、、、·924·20246273Chin J Clin HealthcJune 2024 Vol． 27 No． 3 3． 2 studyJ． Int J Environ Ｒes Public Health2023 20 31831．2WANG YZHAO L GAO L et al． Health policy and public healthimplications of obesity in ChinaJ． Lancet Diabetes Endocrinol20219 7446-461．3．J．202023 5704-708．4LIN XLI H． Obesity epidemiology pathophysiology and therapeu-ticsJ / OL． Front EndocrinolLausanne202112 706978．DOI10． 3389 / fendo． 2021． 706978．5ABIＲI BHOSSEINPANAH F BANIHASHEM S et al． Mentalhealth and quality of life in different obesity phenotypesa system-atic reviewJ． Health Qual Life Outcomes2022 20 163．6．J．201922 6852-855．7JOSHI SMOHAN V． Pros＆Cons of some popular extreme weight-loss dietsJ． Indian J Med Ｒes2018 148 5642-647．8ZHANG QZHANG C WANG H et al． Intermittent fasting versuscontinuous calorierestriction Which is better for weight lossJ． Nutrients2022 14 91781．9CLOETENS LELLEGAＲD L． Energy a scoping review for theNordic Nutrition Ｒecommendations 2023 projectJ / OL． Food Nu-tr Ｒes2023 67 10233． DOI10． 29219 / fnr． v67． 10233．10TSITSOU SZACHAＲODIMOS N POULIA K A et al． Effects oftime-restricted feeding and ramadan fasting on body weight bodycompositionglucose responses and insulin resistance a systematicreview of randomized controlled trialsJ． Nutrients 2022 14224778．11CELIK OYILDIZ B O． Obesity and physical exercise J． MinervaEndocrinolTorino 2021 46 2131-144．12．J．202140 427-28．13YU Z WLU M J YU Z et al． Mechanism and protocol optimiza-tion of acupuncture in treatment of obesity based on sympatheticnerve systemJ． Policy Ｒes2022 47 8744-748．14．J．2022896-101．15．J．202213 1450-52．16．《》J．201430 278-79．17WU SCOOMBS D M GUＲUNIAN Ｒ． Liposuction Concepts safe- tyand techniques in body-contouring surgery J． Cleve Clin JMed2020 87 6367-375．18AＲTEＲBUＲN D ETELEM D A KUSHNEＲ Ｒ F et al． Benefitsand risks of bariatric surgery in adultsa review J． JAMA20203249879-887．19．22019J．201939 4301-306．20．J．201220 663．21．J．201636 112032-2035．22．J．201726 283189-3192．23HASSEN GBELETE G CAＲＲEＲA K G et al． Clinical implica-tions of herbal supplements in conventional medical practicea usperspectiveJ / OL． Cureus 2022 14 7e26893． DOI10．7759 / cureus． 26893．24ABDI BESHIＲ SAHMED ELNOUＲ A SOOＲYA A et al． A nar-rative review of approved and emerging anti-obesity medications J /OL． Saudi Pharm J 2023 31 10101757． DOI10． 1016 / j．jsps． 2023． 101757．25MAＲKHAM A． Setmelanotidefirst approval J． Drugs 2021 813397-403．26ONAKPOYA I JLEE J J MAHTANI K Ｒet al． Naltrexone-bupro-pionMysimbain management of obesitya systematic reviewand meta-analysis of unpublished clinical study reports J． Br JClin Pharmacol2020 86 4646-667．27XIE ZYANG S DENG W ET A L． Efficacy and safety of liraglu-tide and semaglutide on weight loss in people with obesity or over-weighta systematic reviewJ．Clin Epidemiol 2022 141463-1476．28PASS ABIALONCZYK D CHIQUETTE E et al． Oral superabsor-bent hydrogelPlenity for weight management J． Ann Pharma-cother2021 55 91146-1152．29．J．202136 91297-1302．30LEI X GＲUAN J Q LAI C et al． Efficacy and safety of phenter-mine / topiramate in adults with overweight or obesitya systematicreview and meta-analysis J． ObesitySilver Spring2021296985-994．31DHILLON S． Phentermine / topiramatepediatric first approval J．Paediatr Drugs2022 24 6715-720．2023-10-19