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2 3 11 12 58 Conyers & Dill Pearman MUFG Fund Services (Bermuda) LimitedThe Belvedere Building69 Pitts Bay RoadPembroke HM08Bermuda 1831712-1716 Clarendon House, 2 Church StreetHamilton HM11, Bermuda 993302 www.grandpharma.cn •4.88100% •2.6100%Ryaltris® •GPN00884I •Tarsus1,500TP-03 •RDCITM-11III•GPN00884IND•GPN00833APP13007NDAFDA •Ryaltris®NDA •HPV-16ARC01 (A002)IND •6.31890% AF(Atrial Fibrillation)ARAPERTO® OTWARDSccRCCCOVID-19EMAFDA(United States Food andDrug Administration)GABA-ClGEP-NETsGrand Pharma SphereGrand Pharma Sphere Pte LimitedHPV-1616ICSINDITMITM Isotope Technologies Munich SEIVUSLABA2LAMA LEGFLOW® OTWLNPMRMRAmRNANDANMPANovasightNovasight Hybrid SystemOCTPCIRyaltris®GSP 301 NSRDCRESTORE DEB®SARS-CoV-2SirtexSirtex Medical Pty LtdTarsusTarsus Pharmaceuticals, Inc.TelixTelix Pharmaceuticals Limited 3315516336114®®®®®[90Y]LavaTM®®®®®Q10 ccRCCTLX250-CDxI GEP-NETsITM-11(Investigational New DrugINDIII GSP 301 NSRyaltris®GPN00187IGPN00204INDIAPADI CBT-001IIIGPN00884I mRNA 16HPV-16ARC01I 5 3 6 100%Ryaltris® 90% 100% 20182023 650SirtexTelix Pharmaceutical LimitedTelixITM Isotope TechnologiesMunich SEITMRDC1268Ga177Lu131I90Y89Zr57RDC12 ®[90Y]RDC®[90Y] ®[90Y] ®[90Y]SIRT5015(BCLC)NCCNESMO (European Association for the Study of the LiverEASL)National Institute for Health and Care ExcellenceNICECSCO202420232021 ®[90Y] ®[90Y]®7022407®103®62.6%4085% ®FDA701,000®140®50659® ®[90Y]4022027 LavaTM LavaTMLavaTM320LavaTM RDC GPN00289 GPN00289 KonaTM KonaTMKonaTMFDA(PremarketApprovalPMA) AuroLase® AuroLase®AuroLase®FDAPMA RDC 9 TLX591/TLX591CDx TLX591(PSMA)RDC(rPFS)8.8IIITLX591-CDxPSMARDCTLX591TLX591-CDxTLX591-CDxIII TLX250/TLX250CDx TLX250TLX250-CDxTLX250-CDxFDA(CT)(MRI)ccRCCTLX250-CDx(PET)ccRCC86%87%FDA70%93%T1accRCC4cmTLX250-CDx85%89%TLX250-CDxccRCCccRCCTLX250-CDxFDATLX250-CDxCAIXTLX250-CDxIITLX250II GEP-NETsITM-11/TOCscan® ITM-11TOCscan®ITM-11FDAEMAIIIIIIITOCscan® TLX101 TLX101RDCL1LAT-1FDAI/IITLX101I ITM-41 ITM-41177LuRDC 148NOVASIGHT HybridHeartLight X3 +2005060% RESTORE DEB®APERTO®OTWSAFEPAXNovasight Hybrid SystemNovasightPCIOTWOver The Wire®®®® RESTORE DEB®JACCJournal of the American College of CardiologyCardiovascular Interventions APERTO®OTW APERTO®OTWAPERTO®OTWA m e r i c a nJ o u r n a l o f K i d n e yDiseases Novasight NovasightIVUSOCTFDA LEGFLOW®OTW LEGFLOW®OTWSAFEPAX LONG LONG624 aXess aXessESRDAVGaXessAPERTO®OTW Saturn Saturn HeartLight X3 HeartLight X3atrial fibrillationAFFDAAFHeartLight X3AFHeartLight X3 CoRISMA CoRISMA mRNA ®®®® ARDS ®®®®® ® 2022-20232023-202420212021202120202020 ®®II®®IIIII ®®2LABAICS(1)ICSLABALAMAICS-LABAICS-LABALAMA®®(2)(3)®IIIARGON®®2443%®®ICSLABA12®®III®®26%22%19%2023 2022 ARDS Ryaltris® Ryaltris®12IIIRyaltris®Patanase®NS®NSRyaltris®NDA STC3141: STC3141Nature CommunicationsCritical CareARDSCOVID-19COVID-19ARDSIbARDSIbCOVID-19IIaII APAD: APADSTC3141II OTC++ 2022201830 14 ® 2021202020192017• GPN00833: IIIGPN00833FDAIII GPN00153CBT-001: IICBT-001IIIIII GPN00136BRM421: BRM421IIIIIII GPN00884: GPN00884I GPN01768TP-03 -GABA-ClGABA-ClFDAFDAIIIII 30141620 Q10 ® AHA202120212021202120212018201820172016 ESC2 ® Jext® 2110 ® (2016)120172020202020202022 ®Q10 2024(2021)(2021)2020201820 ® MRAmineralocorticoid receptorMRMR20182022MRAMRAMRMRA ®® mRNA mRNAmRNAmRNALNP16HPV-16ARC01 (A002)IHPVmRNALNPHPV-16E6 E7mRNATriMix®LNPTriMix® 1103006050 20 EU GMPWCKFDAISOFSSC22000GRASHALALKOSHER 5024FDA 14050%500 6,047,240,0005,989,490,0001.0%5.4%1,557,950,00051.4%58.0%11,081,310,00035.1%41.0% 342,750,000148,590,000140.8%207,240,000104,200,000107.6%135,510,000 1.Telix 3,772,940,0003,982,170,000962,550,000830,270,00021.0%®®®®1,230,820,0001,310,980,0001,167,410,0001,461,290,00016.6% 1,931,540,0001,858,730,0008.5%1,502,070,0001,534,440,0002.2% 1,611,950,000606,200,0001,637,680,000695,890,00025,730,00089,690,000 86,120,000113,230,000 14.80 4,519,360,0001,451,300,0001,350,540,000 3,517,760,000688,060,000243,880,000395,540,000 5% A:Grand Pharma Sphere57.98%Grand Pharma Sphere23,301,00089,070,000 B:55%46,690,000104,700,000 C:5% 1.Grand Pharma Sphere 2. 3. 14149 mRNAmRNA RDC 70045060% 3821 30503162%3708428128144PCT53mRNAPCT231 4,1003,600OTC70,00013,000OTC1,000271001,50040050®[90Y] 8320 + • 631,800,00090% • Tarsus Pharmaceuticals, Inc.Tarsus1,500TP-03 • 2.6100%Ryaltris®®®II®®IIIII • 4.88100% 1. 40,206,351(1)(2)39,193,773.9727 5,000,00010,000,00011,200,00010,000,000644,135 278,560,000268,730,00047,761,5001.35% 5%177,478,5571%35,495,711 10,77510,534 10 3.13 14 XVXV78352 35278 XV23336 1.Outwit1,671,671,149Outwit99.85%0.15%1,671,671,149 2.70%255,142,14830,897,005286,039,153 3.41,520,0001,999,230,302 4.CDH Giant356,648,142CDH GiantCDH FundCDH Fund356,648,142CDH FundCDH VCDH VChinaDiamond V80%China Diamond VChina Diamond100% 5.CNCB (Hong Kong) Investment Limited208,750,000 China CITIC Bank Corporation LimitedCNCB (Hong Kong) Investment Lim
