腾盛博药-B2023年度报告

Brii Biosciences Limited騰盛博藥生物科技有限公司 ()於開曼群島註冊成立的有限公司 股份代號 :2137 2023年度報告 2 3 5 6 7 21 31 62 78 83 85 87 88 90 152 2018的使命是 HBVBRII-179siRNA BRII-835 (elebsiran)BRII-877 (tobevibart)HBV2023BRII-1792024 BRII-693HBV HBVMDR/XDRHIVCNS Zhi HONG Robert Taylor NELSEN Gregg Huber ALTONMartin J MURPHY JRGrace Hui TANG Grace Hui TANG Maples and Calder (Hong Kong) LLP Martin J MURPHY JRGrace Hui TANG • Gregg Huber ALTONZhi HONGMartin J MURPHY JR PO Box 309, Ugland HouseGrand Cayman KY1 – 1104Cayman Islands Robert Taylor NELSENGregg Huber ALTON 1617 173100192 First Citizens BankGoldman Sachs International BankJ.P. Morgan Chase Bank WeWork One City CenterSuite 05-110, 110 N Corcoran StDurham, NC 27701United States of America www.briibio.com 3485 2137 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman KY1-1102Cayman Islands 2021713 2023HBVHBVHBV HBVBRII-179BRII-835(elebsiran)BRII-877 (tobevibart)HBV BRII-179HBV20237BRII-17920242BRII-179BRII-179VBI BRII-179HBVBRII-179CHB 2024BRII-179HBV2024BRII-835PEG-IFNα2Virelebsiran(BRII-835)tobevibart (BRII-877) HBVMDR/XDRHIVCNSHBV HBV2024 Zhi HONG HBV HBVVirelebsiranPEG-IFNαBRII-179elebsirantobevibartPEG-IFNαBRII-179PEG-IFNα2024BRII-179HBV HBVBRII-179VBIVBI CdaSciVacBRII-179BRII-179/PreHevbriTMBRII-179/PreHevbriTMRehovotHBV 20232HBsAgHBV 10HBV (1)2 •BRII-179/PEG-IFNα•BRII-179/BRII-835•BRII-835/PEG-IFNα (2)ElebsiranVIR-2218 (3)TobevibartVIR-34342VIR (4)VBIPreHevbriTM/PreHevbrio®20237 (5)AN2 HBV HBVHBVMDR/XDRHIVCNS VirVBIHBVHBVHBV87 BRII-179 BRII-179HBVPre-S1Pre-S2SHBVBT •202311BRII-179CDEHBV •202311AASLD The Liver Meeting®BRII-179HBsAgHBs BRII-179PEG-IFNαHBsAg B R I I -179B R I I -179e l e b s i r a n1b /2aBRII-179 •2024BRII-179HBV •202432833BRII-179PEG-IFNα2NRTI ElebsiranTobevibart ElebsiranBRII-835VIR-2218HBVRNANsiRNA TobevibartBRII-877VIR-3434HBV10TobevibartXencorXtend™FcHBVT •elebsiranPEG-IFNα2elebsiranPEG-IFNαHBVBRII-1792024 •202311VirAASLDMARCHBtobevibartPEG-IFNαelebsiran24tobevibart+elebsiran+PEG-IFNα15.0%tobevibart+elebsiran14.3%482024 •A A S L D2 0 2 414 2V i rSOLISTICE12tobevibartelebsiran65HDVRNA66HDV RNA2024242024 •Tobevibart1PK PreHevbriTM PreHevbriTMHBVPreHevbrio®PreHevbriTMSci-B-Vac® •20237PreHevbriTMPreHevbriTMCDEINDPreHevbriTM HBV BRII-693MDR/XDRBRII-693BRII-693MDR/XDR FDABRII-693QIDPFDA •20236BRII-693BRII-693BRII-693 •20234BRII-693pre-IND1PKPK332025 HIV BRII-753NCEBRII-753HIV •BRII-753 BRII-732NCEEFdAHIVBRII-732NRTTIHIV •BRII-7321HIV BRII-658(Epetraborole)LeuRSepetraborole (BRII-658) •20242AN2epetraborole2/33 BRII-296PPD/MDDAPPD/MDD •20239BRII-296PPD220242 BRII-297 •BRII-2971BRII-2972024 •BrianA.Johns •PharmaVoice2023PharmaVoice100MSCI ESGA CROCMOCDMO ZhiHongDavidMargolisBrianA.Johns 202312314.027 PreHevbriTM HBVVirHBVBRII-179 CNSHIVPreHevbriTM PFIC 2023123120231231BriiBiosciences OffshoreLimited72.8% 1.1295-1(j)(1)2024412PFIC20231231PFIC2023PFICPFIC2023PFICPFIC 1. COVID-192022123151.651.0202312310.6 2. 20221231107.955.820231231163.770.815.0 3. 2022123112.3264.720231231252.4 4. 2022123130.110.52023123119.6 5. 20221231440.637.920231231402.7COVID-1934.65.3 6. 20221231168.627.920231231196.520221231100.825.720231231126.5202320227.1IT 7. 20231231202212312,999.32,661.4 8. 9. (1) (2)100% 10. 20231231 20231231 20231231163.2 11. 2023123120231231 12. 2023123120221231 13. 2023123137.9%42.9%19.2% 14. 2023123112820231231 2023123130220221231294 15. ZhiHONG60201832202132420213242018223202291202171320229120217132022930 Hong20181BriiBiosciences,Inc2019220185201811BriiBiosciencesOffshore Limited Hong25GlaxoSmithKlineplc.GSKG S K2007420183ViiVHealthcare LimitedViiVGlaxoSmithKlineplc.HIV20091020183HIV20061220073ArdeaBiosciences,Inc.2000620073Bausch Health Companies Inc.Valeant Pharmaceuticals InternationalBHC Hong1985719921 4620229302022916202091202148202232220218202172021620233Brii Biosciences Pty Ltd Terns Pharmaceuticals, Inc.TERN20196202082018120196201692017122014820169Ropes& Gray LLP2012920148Davis Polk & Wardwell LLP2007920099Salk Institute for Biological Studies 1999720021020076201262013120168 Robert Taylor NELSEN60201862220213242021713 1994NelsenARCHVenture Partners30201852552202210201892018820171PrimeMedicine,IncPRMESanaBiotechnology, IncSANALyell ImmunopharmLYELVir Biotechnology Inc.VIR Nelsen2021320224RenovationHealthcare Acquisition Corp.REVH20158201810SiennaBiopharmaceuticals,Inc.SNNA2012820186SyrosPharmaceuticals,Inc.SYRS2013820183JunoTherapeutics,Inc.JUNO20061201412KYTHERABiopharmaceuticals,Inc.KYTH20071220176AgiosPharmaceuticals Inc.AGIO2013920163SageTherapeutics,Inc.SAGE20142201511BellerophonTherapeutics,Inc.BLPH19941120045AdolorCorporationADLR1998620068Illumina,Inc.ILMN2007920146FateTherapeutics,Inc.FATE2000720137NeurogesX,Inc.NGSX201111202012UnityBiotechnology,Inc.UBX2018820216KarunaTherapeuticsInc.KRTX2017620216BeamTherapeutics Inc.BEAM2015520226Denali Therapeutics, Inc.DNLI201262