腾盛博药-B2024 中期报告

Brii Biosciences Limited騰盛博藥生物科技有限公司 ()於開曼群島註冊成立的有限公司 股份代號 :2137 2 3 5 18 42 43 45 47 48 49 67 騰盛博藥2018騰盛博藥騰盛博藥騰盛博藥 騰盛博藥HBVHBVelebsiranHBVsiRNABRII-835tobevibartBRII-877BRII-179HBVHBV HBsAgHBV騰盛博藥HBV騰盛博藥2024 騰盛博藥HBVHBV HBV騰盛博藥HBVHIVMDR/XDRCNS Zhi HONG Martin J MURPHY JRGrace Hui TANGGregg Huber ALTON Grace Hui TANG Maples and Calder (Hong Kong) LLP Martin J MURPHY JRGrace Hui TANG Gregg Huber ALTONZhi HONGMartin J MURPHY JR • Gregg Huber ALTON PO Box 309, Ugland HouseGrand Cayman KY1 – 1104Cayman Islands 173100192 First Citizens BankGoldman Sachs International BankJ.P. Morgan Chase Bank WeWork One City CenterSuite 05-110, 110 N Corcoran StDurham, NC 27701United States of America www.briibio.com 2137 3485 2021713 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman KY1-1102Cayman Islands 1617 HBVHBVHBVBRII-179PEG-IFNαelebsiranPEG-IFNαBRII-179PEG-IFNαelebsirantobevibartHBVelebsirantobevibartBRII-179CDEHBV2024 VBIHBV2024HBV HBsAgHBVHBVHBsAgHBV 10HBVHBV * (1)騰盛博藥2 •Elebsiran + BRII-179•BRII-179 + PEG-IFNα•ENSUREelebsiran ± PEG-IFNαPEG-IFNα (2)ElebsiranBRII-835VIR-2218 (4)VBIPreHevbrio/PreHevbri騰盛博藥20237 (5)EpetraboroleBRII-658AN2 HBV 2024HBVHBVHBsAgBRII-179siRNAPEG-IFNαHBV HBVMDR/XDRHIVCNS HBVHBVHBV87 ElebsiranTobevibart ElebsiranBRII-835VIR-2218HBVsiRNAHBVRNAHBVHDVsiRNA2020Virelebsiran TobevibartBRII-877VIR-3434HBVHBVHDVTobevibartXencorXtend™FcHBVHDVT2022Virtobevibart •2024elebsiranBRII-179PEG-IFNα •20245CDEelebsirantobevibart•2024EASL™Vir2SOLSTICEtobevibartelebsiran122448ALT60SOLSTICE242024•MARCHBPEG-IFNαelebsirantobevibart482024•elebsiranPEG-IFNα2ENSURE2024•Tobevibart1 BRII-179 BRII-179HBVPre-S1Pre-S2SHBVBT •202462024EASL™2BRII-179elebsiranHBVBTPEG-IFNαBRII-179HBsAgBRII-179HBV •20242本公司VBIBRII-179VBI-1901 HBV PreHevbriTMHBVPreHevbrio®PreHevbriTMSci-B-Vac® •PreHevbriTM BRII-693MDR/XDRBRII-693BRII-693MDR/XDR FDABRII-693QIDPFDA •BRII-693202471PKIND3 HIV BRII-753NRTTIEFdANCEBRII-753HIV •BRII-753 BRII-732NCEEFdAHIVEFdANRTTIHIV •BRII-7321HIVBRII-732HIV EpetraboroleBRII-658LeuRSepetraborole •AN22024823EBO-301AN2EBO-3012803EBO-301epetraborole BRII-296PPDAPPD •BRII-296PPD2BRII-296 BRII-297 •BRII-2971BRII-2972024BRII-297 Zhi HongDavid MargolisBrian A.JohnsEllee de Groot 2024630126.2 HBVVirHBVHBV HBV 2024630 1. 2024630COVID-190.6 2. 202363085.915.0202463070.917.3 3. 202363023.3138.72024630115.4 4. 20236304.55.520246301.0 5. 2023630202.276.02024630126.2HBV36.636.4 6. 2023630102.824.2202463078.6202363065.021.7202463043.3 7. 2024630202312312,661.42,477.8 8. 9. (1) (2)100% 10. 202463017.8 2024630 2024630161.9 11. 20246302024630 12. 202463020231231 13. 202463045.5%38.0%16.5% 14. 2024630952024630 202463096.22023630155.0 15. 202171326.14 2023324 2027 C1C.2.1 C.2.1Zhi HongZhi HongZhiHongZhiHong C3 2024630 Grace Hui TangGrace Hui Tang 20246302024630 202313.51B(1) 2024630 2024630XVXV78352 1.2024630729,989,776 2.ARCH Venture Fund IX, L.P.45,205,210ARCH Venture Fund IX, L.P.ARCHVenture Partners IX, L.P.ARCH Venture Partners IX, L.P.ARCH Venture Partners IX, LLCARCH Venture Partners IX, LLCRobert Taylor Nelsen2024713Clinton BybeeKeith CrandellARCH VentureFund IX Overage, L.P.45,205,208ARCH Venture Fund IX Overage, L.P.ARCHVenture Partners IX Overage, L.P.ARCH Venture Partners IX Overage, L.P.ARCH VenturePartners IX, LLCRobert Taylor NelsenARCH Venture Fund IX, L.P.ARCH Venture Fund IX Overage, L.P. 3.ZhiHong54,507,739(i)124,906(ii)12,000,000(iii)8,787,333(iv)1,195,500(v)Jingfan Huang 2020Zhi Hong 202016,400,000(vi)Hong202016,000,000 4.8,012,833(i)1,152,207(ii)3,066,668(iii)2,590,833(iv)1,203,125 5.Martin J Murphy Jr87,000(i)73,000(ii)14,000 6.Grace Hui Tang87,000(i)73,000(ii)14,000 7.87,000(i)73,000(ii)14,000 8.GreggHuber Alton87,000(i)73,000(ii)14,000 9.327,000(i)109,000(ii)218,000 2024630XVXV78352 2024630XV23336 1.2024630729,989,776 2.ARCH Venture Fund IX, L.P.45,205,210ARCH Venture Fund IX, L.P.ARCHVenture Partners IX, L.P.ARCH Venture Partners IX, L.P.ARCH Venture Partners IX, LLCARCHVenture Partners IX,LLCRobertTaylor Nelsen2024713Clinton BybeeKeithCrandellARCHVenture Fund IX Overage, L.P.45,205,208ARCH Venture Fund IX Overage, L.P.ARCH Venture Partners IX Overage, L.P.ARCH Venture Partners IX Overage, L.P.ARCHVenture Partners IX, LLC ARCH Venture Partners IX, LLCRobert Taylor NelsenClinton BybeeKeith CrandellARCH Venture Fund IX, L.P.ARCH Venture Fund IX Overage, L.P. 3.BoomingPassion Limited72,019,612BoomingPassion LimitedBoyuCapital Fund III,L.P.BoyuCapital Fund III,L.P.BoyuCapital General Partner III,L.P.BoyuCapital General Partner III, L.P.Boyu Capital General Partner III, Ltd.Boyu Capital GeneralPartnerIII,Ltd.BoyuCapital Group Holdings Ltd.Boyu Capital Group Holdings Ltd.BoyuGroup, LLCBoyu Group, LLCXYXY Holdings Ltd.XYXY Holdings Ltd.100% Boyu Capital Fund III, L.P.Boyu Capital General Partner III, L.P.BoyuCapital General Partner III, Ltd.Boyu