君圣泰医药-B：(经修订标题) 截至二零二五年十二月三十一日止年度的全年业绩公告以及所得款项用途变更

HighTide Therapeutics, Inc. 2511 君聖泰醫藥 (CKM) CKM HTD1801(NME)CKMHTD1801AMPKNLRP3AMPKNLRP3HTD1801Lp(a)ApoBALT/ASThs-CRPHTD1801HTD1801 HTD1801AMPKNLRP3CKMCKMCKMCKM90%80%5.9CKMCKMHTD1801CKMHTD1801HTD1801CKM 4,580HTD1801HTD1801CKM(T2DM)(CKD)(MASH)(PSC)HTD1801HTD4010HTF1037 HTF1057 HTD1804HTD18058 100+HTD1801 6826 HTD1801 •HTD1801CKMT2DMCKD MASHPSC HTD1801•HTD1801T2DMIII(NMPA)HTD1801T2DM(NDA)MASHIIb (T2DM) •T2DMT2DM2-4T2DM •T2DMIbIIIIIHTD1801(HbA1c)HTD1801HOMA-IRT2DMIbIIIIIMASHT2DMIIaHTD1801 •61(EASD)HTD1801T2DMIII(SYMPHONY-2) HTD180124HbA1c(LS)-1.21%-0.68%LS-0.53%p0.000133%HTD180124HbA1c7%11%p0.000124HTD1801 HTD1801eGFR HTD1801 HTD1801 HTD1801 •(ADA)85III(SYMPHONY-1)HTD1801T2DM HTD1801HbA1c(-1.3%)42%HTD1801HbA1c7%HTD1801HbA1c≥8.5%HTD1801HbA1c-1.5%HTD1801HbA1c HTD1801(LDL-C)(non-HDL-C) HTD1801T2DMγ(GGT)C(hs-CRP)T2DM HTD1801 •(EASL)T2DM IIHTD1801T2DM(MASLD) HTD1801T2DMMASLDHTD1801 •JAMA Network OpenHTD1801T2DMII12HTD1801HTD1801T2DM • •60EASDT2DM IIHTD1801T2DMHTD1801EASD T2DMMASHHTD1801HTD1801T2DMMASH HTD1801T2DMMASH •84ADAT2DM IIHTD1801T2DMHbA1c HTD1801HTD1801T2DMMASHT2DM •S Y M P H O N YH T D 1 8 0 1T 2 D MI I I(SYMPHONY-1SYMPHONY-2)HTD1801SYMPHONYIII2452SYMPHONY-1(NCT06350890)SYMPHONY-2(NCT06353347)IIIHTD1801(SYMPHONY-1)(SYMPHONY-2)T2DMHTD180124HbA1c28(OLE)HTD180152HTD1801 2452HTD1801 HTD180152HTD1801HTD1801 •HARMONYHTD1801T2DMIII(HARMONY)T2DMHTD1801HARMONY(NCT06415773)IIIHTD1801T2DM24HbA1c IIIHTD180124HbA1cLS-1.12%-0.93%LS-0.20%95% CI-0.37 ~-0.03P < 0.001 HTD1801HTD1801LDL-Cnon-HDL-CHTD1801HbA1c<7.0%Lp(a) HTD18013.8%4.4%HTD1801 •HTD1801T2DM (CKD) •CKD •HTD1801CKDeGFR24T2DMeGFR60-89 mL/min/1.73m²HTD1801eGFR •HTD1801HTD1801 •22(CVCT)HTD1801CKDCVCT CKMHTD1801 T2DMIIISYMPHONYHTD1801eGFRHTD1801HTD1801 •58(ASN)HTD1801ASN 2025 HTD1801T2DMIIIHTD1801eGFReGFRHTD1801eGFRHTD1801 •HTD1801 •HTD1801CKDT2DMIIT (MASH) •HTD1801MASHT2DMIIaIIaHTD1801 •HTD1801T2DMMASHIIb48%(NAS)≥2MASH •IIa •EASLIIaMASHMASHT2DMHTD1801 HTD1801MASHHTD1801(MRI-PDFF)(cT1) •( A A S L D )MASH IIaHTD1801AASLD 1(GLP-1RAs)HTD1801MASHT2DMGLP-1RAsHTD1801 HTD1801(GI)HTD1801 •MASHMASHHTD1801 IIa •EASLMASHIIaHTD1801GLP-1RAsHTD1801HTD1801EASL GLP-1RAsHTD1801MASHT2DMGLP-1RAsHTD1801 T2DMMASHHTD1801MASHHTD1801HTD1801MASHT2DM H T D 1 8 0 1HTD1801MASH •HTD1801T2DMMASHIIaT2DM3IIIHTD1801T2DMHTD1801MASH(FDA) •196.5(BMI) •HTD1801CKMHTD1801MASHT2DMIIa3.5kg8kg •GLP-1RAsHTD1801GLP-1RAs •(Obesity &Weight Loss Drug Development Summit)HTD1801 HTD1801HTD1801GLP-1RAsHTD1801 •HTD1801GLP-1RAII (PSC) •PSCPSCEASLHTD1801 •HTD1801PSCHTD1801PSC •HTD1801PSCIIHTD1801HTD1801HTD1801HTD1801PSCIIIII HTD4010 •HTD1801(AH)AHHTD4010AH •HTD4010IAHAHHTD4010Toll4AHEASL(DDW)HTD4010 •EASL(DDW)HTD4010 HTD4010DUR-928HTD4010 HTD4010 HTF1037 •HTF1037GLP-1RAHTF1037NASASTALT(ROS)HTF1037HTF1037 HTF1057 •HTF1057HTF1057HTF1057(BDNF) HTD1804 •HTD1804T2DM •HTD1804HTD1804 HTD1805 •HTD1805HTD1805HTD1801HTD1805 HTD1801T2DMT2DMHTD1801T2DMCKDMASHPSC CKM(i)(ii)(iii)(iv)(v) 68.049.019.072.1%29.89.9 3.225.020.1 (i)(ii)(iii)(iv) 363.554.7%164.5156.2 81.227.2%59.1 2.41.50.9 232.1381.8 532.2325.9206.3 98.350.932.58.76.2 110.056.92.6%3.5% (1)(2) 30.2%13.4%5.44.7 (1)(2) Apollo Multi-Asset GrowthFundApolloChaince Capital Fund LPChaince12.5 Apollo6.4Apollo Chaince2.014.1Chaince1.812.80.21.3Chaince Apollo12,375Apollo176.8 69.743.51.5 32.1% 0.074.3(i)(ii) (232,101)(381,788)27,09496,932(205,007)(284,856) 51 32436613215170 49.2108.2 D. C12C.2.1 C.2.1 C3 194.19.3 HTD18019.0HTD18044.6%HTD1801 HTD1801 60,000,0002.21 56,555,0002.21(HTD1801)HTD1801 123.42.69110.4 H T D1801(MASH)IIb H T D18012( T2D M )(NDA) 183171712-1716 (www.hkexnews.hk)(www.hightidetx.com) (232,101)(381,788) (232,101)(381,788) 8(0.51)(0.84) (232,101)(381,788) (239,654)(375,538) (239,654)(375,538) 433,900403,425 1. 君聖泰醫藥（「」）Great Mantra Group LimitedCricket Square, Hutchins Drive, P.O. Box 2681, Grand Cayman KY1-1111, Cayman Islands24840 HighTide Therapeutics,Inc. 2.1 2.2 21 2.3 18 181187733 1818 3. 8 4. *** *2024 ** 5. 6. 8.25%8.25% 15%15% 20% 25%25% 21%21%8.25%8.25%8.84%8.84%5.50%5.50%6.50%7.50% 7. 8. 479,740,151452,076,548 9. 50,88851,473 *4,400,000 君聖泰醫藥