华熙生物医美产品临床应用学术文献集

Academic Literature Collection on Clinical Application ofBLOOMAGE BIOTECH Aesthetic Medicine Products Academic Literature Collection on Clinical Application of BLOOMAGEBIOTECH Aesthetic Medicine Products 41322283240455664687381 8591102116123131139148152157 Academic Literature Collection on Clinical Application of BLOOMAGEBIOTECH Aesthetic Medicine Products 170178184192196201 RESEARCH ARTICLE Clinical outcomes of intense pulsed light combined with non-crosslinkedsodium hyaluronate, tranexamic acid, and vitamin C mesotherapy for facialphotoaging: a retrospective study Houhuang Qiu*, Jialu Xu*, Xixin Wu, Yutong Wu, Xi Chen, Ping Zhong, Fangfang Wang, Qiusheng Lin, Fei Liand Tianhua Xu medicalcosmeticcenter, Shenzhennanshan People’s Hospital, Shenzhen,china ARTICLE HISTORYReceived 17 November 2025 ABSTRACTBackground:Facial photoaging involves structural and functional deterioration across multiple skin layers. Single-modality treatments rarely address pigmentary, vascular, and dermal matrix changesconcurrently. Intense pulsed light (IPL) is widely used for the treatment of dyschromia and vascularlesions. Mesotherapy incorporating non-crosslinked sodium hyaluronate (NCSH), tranexamic acid (TXA),and vitamin C (VC) has been introduced to improve skin hydration and related dermal parameters. Thepresent study assessed the efficacy and safety of combining these modalities for facial rejuvenation.Methods:Eighty-four patients underwent three sessions of IPL with mesotherapy. Standardized VISIA Accepted 20 December 2025 KEYWORDSFacial photoaging; intense pulsed light; non-crosslinkedsodium hyaluronate;Tranexamic acid; Vitamin C;mesotherapy imaging was conducted before each treatment (T0, T1, T2) and at 1–2months (T3) and 3–6months (T4)post-treatment. Efficacy was assessed using the Modified Fitzpatrick Wrinkle Scale (MFWS) and GlobalAesthetic Improvement Scale (GAIS); adverse events and satisfaction were recorded.Results:All six VISIA parameters and MFWS scores improved significantly (p<0.001), peaking at T3 with mild non-significant rebound at T4. GAIS and satisfaction assessments confirmed consistent aestheticimprovement. No severe adverse events occurred; transient burning, papular reactions, and erythemawere most common. The overall satisfaction rate was 82.15%.Conclusions:IPL combined with NCSH/TXA/VC mesotherapy provided safe, effective, and well-tolerated improvement in facial photoaging, representing a promising multimodal rejuvenation approach. synthesis, restoring dermal structure and elasticity. Consequently, IPLhas become a cornerstone non-ablative modality for skin rejuvenation(7–9). However, optical therapies alone offer limited improvement inhydration and extracellular matrix remodeling. To address this, inject-able or mesotherapy-based techniques are increasingly employed toreplenish bioactive substances and enhance the dermal microenviron-ment (10,11). Non-crosslinked sodium hyaluronate (NCSH), a principalmesotherapy component, improves hydration and supports matrixrenewal, creating favorable conditions for fibroblast function and col-lagen synthesis (1,12,13). When combined with IPL, its photothermalsynergy enhances active ingredient penetration and tissue respon-siveness while minimizing adverse reactions due to its non-crosslinked,fully metabolizable nature. In mesotherapy formulations, vitamin C(VC) and tranexamic acid (TXA) are often added to modulate pigmen-tation and improve skin tone uniformity. VC downregulates matrixmetalloproteinases (MMPs), alleviates inflammation, and inhibits tyros-inase to suppress melanogenesis (14), whereas TXA acts on the sameenzymatic target, further reducing melanin synthesis. Their combineduse demonstrates well-documented efficacy in hyperpigmentary dis-orders (15,16).Building on these findings, we integrated NCSH/TXA/VC mesother- 1. Introduction Facial photoaging is a multifactorial biological process driven bychronic environmental exposure. Long-term ultraviolet radiationand reactive oxygen species (ROS) progressively impair dermal col-lagenintegrity and accelerate extracellular matrix degradation.Amongkey components,hyaluronic acid markedly decreases,reducing hydration and elasticity while thinning the epidermal anddermal layers. These changes compromise the skin barrier andmetabolic activity, clinically manifesting as wrinkles, laxity, dyschro-mia, and telangiectasia that reflect cumulative photodamage (1,2).In a 15-year longitudinal follow-up study, the overall prevalence ofsevere cutaneous photoaging rose markedly from 42% at baselineto 88% at the final assessment (3). Recent studies emphasize that effective management of photoa-ging requires multimodal strategies targeting photodamage repair,collagen regeneration, and epidermal homeostasis. Monotherapiesfocusing on a single pathway often produce short-lived or incompleteimprovements (4,5). Intense pulsed light (IPL) therapy, based onselectivephotothermolysis(6),delivers broad-spectrum li