派格生物医药-B2025 中期报告

（A joint stock company incorporated in the People’s Republic of China with limited liability）Stock Code: 2565 （於中華人民共和國註冊成立的股份有限公司）股份代號 : 2565 2025中 期 報 告INTERIM REPORT 4 6 7 24 35 36 37 39 40 51 52 Michael Min XU Davis Polk & Wardwell3A Xiangjun ZHOU 20258262025826 Jiancun ZHANG Michael Min XU20258262025826 Xiangjun ZHOU 1606 Jiancun ZHANG Jiancun ZHANGMichael Min XU 18346 Michael Min XUXiangjun ZHOU www.pegbio.com H 183171712-1716 717710 02565 94 108 6(FIC)(BIC)2025 PB-119GLP-1 PB-1192025522 2025(NDA) ••DTP•• I/II IND I. 20082T2DMNASHOIC II. 2025630INDPEG PB-119GLP-1 PB-119GLP-1T2DMPB-119GLP-1PEGPEG(PEG)(PEG)PB-119 PB-119PB-119 20239PB-119T2DMNDA2025NDAT2DMPB-119PB-119PB-119 2025IIIPB-119PB-119T2DMSGLT-2PB-119T2DMPB-119IIIT2DMT2DMIIIPB-119PB-11920216PB-119IND2024220244PB-119Ib/IIa20246 PB-1192025522 2025(NDA) ••DTP•• PB-119 PB-718GLP-1/GCG PB-718GLP-1GCGNASHPB-718GLP-1GCGPB-718GLP-1GCGGLP-1/GCGPB-718 (PEG)PB-718PB-718I(PB718-001)PB-718Ib/IIaPB-718 PB-718 PB-1902OIC PB-1902OICOICOICOIC PB-1902PB-1902OICIPB-1902(PK)(PD)202210PB-1902OICII2025II PB-1902 PB-722GCG PB-722GCG20215FDAPB-72220235INDPB-722PB-722IND2026IPB-722PKPD2027II PB-722 PB-2301GLP-1/GIPT2DMNASH PB-2301T2DMNASHGLP-1GIPPB-2301PB-2301GLP-1PB-2301T2DMNASH2026IND PB-2301 PB-2309GLP-1/GIP/GCGT2DMNASH PB-2309T2DMNASHGLP-1/GIP/GCGPB-2309PB-2309GLP-1PB-2309T2DMNASH2025IND PB-2309 1013(i)(ii)(iii) 2025630 2025202463026.364.0 CMC 2025630CMCCMC10CMCCMC CDMOCMOCDMO 2025630 PB-119PB-119 ®(PB-119) 1. ® 2. 3. •(KOL)• 4. KV 5. (PV) 6. ® 7. (IIT) PB-119 2024913PB-1192025331PB-1192025630 PB-11920256PB-119PB-119 20256308313152025630HECTOR®(PEG) PB-1192025PB-119 (BIC)(IND) PB-119 PB-119 III. 202563093.72024630155.5 PB-119NDAPB-119 202563093.72024630155.561.8PB-119NDA 202563026.3202463064.037.7(i)202463022.3(ii) PB-119NDA 202563061.3202463091.330.0(i)202463022.8(ii)20255 20242025630106.278.0 202563078.02024630106.2 202563086.8202463073.0 2025630228.820246307.8 2025630264.52024123128.4236.1 202563075.120241231100.024.9 202563020241231 20256302.5%2.9%202412312.6%3.1% 202563032.3%20241231176.6% 202412311.520256309.0 20256305% (i)202344202026443.10%1.39202563021.39 (ii)2023921202481302026813.20%1.61202563031.84 5% 2025630 2025630 20256300.2 202563020241231 2025630 2025630582024123164 12 IV. • • •PB-119PB-119••••••••• I. 20256302024630 II. III. 2 C.2.1 2C.2.1MichaelMinXU20085(i)(ii)(iii) IV. 3.212D.3Xiangjun ZHOU3.10(2)3.21 • • • • • • 20256302025630 V.13.51B(1) 13.51B(1) VI. 2025630XV(a)XV78(b)352(c) 2025630106,791,193279,164,339H (3)2025630MichaelMinXU93.10%MichaelMinXU 2025630XVXV78352 VII. 2025630XV23XV336 VIII. 20256301818 IX. 2025630 X. 2025630 XI. 1.00H2025527H15.619,283,500231.8212.6H12.0219,283,500 2025630 XII. XIII. 13.2013.2113.22 XIV. 2021327 2025112025630 •••••••• 202563029,175,2307.96% 29,175,230 12 •100%•80%•60%20% •40%20% •20%20%•20%• (i)(ii)(iii)(iv) (i)(ii)(20) (i)(ii)(iii) 202563029,175,230 2 0 2 563 02 129,175,2307.96% 365020256303434 2410 202563034 108 2025826 2025630 (78,035)(106,194)–– (78,035)(106,194) (152)(43)–(54)(30,000)(10,142)116,99383,227 53,50065,000(1,412)(1,038)(78,424)(50,000)(805)(704)(145)(67)(1,193)(5,375)H257,284– 1 20255H 342025826 202551920252 34 241035 20241231 2 21 4 (a) (b) 5 25% 20229100%20242025630 20242025630 6 (a) 2 0 2 563 09 3 , 6 1 8 , 0 0 02 0 2 463 01 5 5 , 3 6 7 , 0 0 0370,380,0002024630366,672,000 (b) 20256302024630 7 20256309,559,0002024630 8 20256303.1%3.2%20246303.1%3.2% 13 10 11 2025630 12 2025515.6019,284,0001H300,823,000275,924,00019,284,000234,795,00021,845,000 12 (b) 20256302024630 (c) 2021327 20242312 202563042,572,000202463087,660,000 13 (a) (i) 13 •11•221•3 3 20252024630123 13 (a) (ii)3 13 (a) (b) 202563020241231 14 2025630 15 2025630 www.pegbio.com 1,928,500H 2025919 2025519 2025630 2025112025630 2020828 1.00 15 CDMO 派格生物醫藥 ( 杭州 ) 股份有限公司PegBio Co., Ltd.