康希诺生物2025中期报告

02 04 05 24 32 33 34 37 63 Xuefeng YU Xuefeng YUShou Bai CHAO Xuefeng YU Xuefeng YU (FCG HKFCG (PE)) •8835 185401–420 6185688185 33191901 www.cansinotech.com H 183171712–1716 1526 77334 2025 3(i)®®®Ad5-EBOVPBPVDTcP-Hib-MCV4(ii)®®®DTcPTdcp(iii)CS-2606 mRNACS-2028CS-2023 • ®® ®NDAMCV4® ®IIIMCV2®3623 20211220216®®NDA®MCV4®MPSV4®3347COC® ®363.738.4% 202411MCV433473683MCV4759 202412MCV4MCV41855MCV4 20252MCV4(LPPOM MUI)MCV4 ® ®T2B 20256®NDA®NDA®®® ®®®XBB.1.5 ®5SCOVID-19 ®®®®®®®®® 20212®NDANDA 20229®® 202312XBB.1.5XBB.1.5 Ad5-EBOV Ad5-EBOV50%201710Ad5-EBOVNDAAd5-EBOVGMP Ad5-EBOV(i)2˚C8˚C12(ii)(iii) Ad5-EBOVAd5-EBOV • DTcP DTcP(DTaP)DTcP DTcPDTcPTdcpDTcP 202412DTcPNDADTcPIIIIII 20252DTcPNDANDAs2025DTcPNDA 20252NDA2026NDA 20253 Tdcp Tdcp6TdcpTdcpBoostrixAdacel 202412TdcpII/III TdcpIII • 20241I 202412I/III/II 20257 PBPV PBPV23(PPV23)13(PCV13)2390PBPVAPspAPBPVPPV23PCV13 20244PBPVIIaIbIaIbPBPVIPBPV 20237Barinthus Biotherapeutics(UK)LimitedVaccitech (UK) LimitedShingrixShingrix 202311II I Ad5Ag85AIaI Ib 20255II1849 DTcP–Hib–MCV4 DTcP–Hib–MCV4MCV4®DTcPIIIHibIDTcP–Hib–MCV4 20252DTcP–Hib–MCV42025DTcP–Hib–MCV4I • mRNA mRNACMC (Chemistry, Manufacturing and Controls)mRNAmRNA 20247(NIBM)mRNAmRNA 20256ISLISL-3C-LNPISLISL-3C-LNPISL-3C-LNPmRNA ®®®mRNAmRNA A ®MCV4MCV®®®®® COC®®® 2025630374.12024630285.488.731.1%®MCV4 202563077.5202463098.320.821.1%(i)(ii)202463022.92025630 2025630296.62024630187.2109.467.3%79.3%(i)(ii)(iii) 202463054.174.4%202563094.4(i)48.9(ii)9.8 2024630112.539.0%2025630156.3 202463087.811.4%202563077.8 2024630185.920.5%2025630147.8 202463075.320256302.0(1)70.5(2)4.70.6 – 202563017.1202463021.338.4(1)15.39.0(2)21.(3)6.2 20256305.820246301.0 20241231180.12025630210.7III 20241231280.52025630323.2 20241231439.72025630407.2 20241231737.62025630660.3 202422024 20241231113.7202563091.014.86.2 2024123162.5202563046.22025630 20241231632.314.6%2025630540.0(i)(ii)2024 2024123175.1202563040.5 202412311,556.527.5%20256301,128.4 20256304,334.8202412314,282.51,128.41,340.91,865.5 20256301,758.9202412311,772.01,008.2540.0210.7 202563081.420241231377.4926.820241231514.8864.4202412311,098.5MCV4 2025630505.8833.8 20256302,244.7886.9 202433ª Vara Civel de Maringa/PRBelcher Farmaceutica Ltda.Belcher2021COVID-19167219 BelcherBelcher2025630 2025630 202563037.220241231129.271.2% 20256302025630154.920241231158.9 202563020241231 2025630 (i)(ii)202563074.4533.012 3100% 202563013.18%202412318.14% C.2.1Yu(i)(ii)Yu(iii) B.3.520251231B.3.5 20255688588 20256600820 13.51B(1) 2025630 • •2410 2024630 2025630XV352 (1)(L) –(2)2025630(3)(4)ChaoMaoChaoMaoMaoCHAMPDENLLCMedicharms LLC 2025630352 20256 30336 (1)(L) – (2)2025630 (3) (4)20247242024123Mao6,000,000H1,127,372HCHAMPDEN LLCMedicharms LLC2024724202412320247252024124 2025630336 HA H H1,309.81,122.3HA20208212020630H682.82020109202212220221130H100DTcPDTcP20221221H2022125 2025630HHAH A 2020813AA4,979.5A2021429A2021528A2021512 A2025630 (1)2021429II20215282,244.7(i)AII550.0(ii)A550.0(iii)2021512A202482920262024829A (2)2023328A150.0DTcP-Hib3030DTcP2023630202368A202482920252024829A (3)A(i)1,000.0A(ii)3,979.5AA (4)20201092021101120221221A3,429.5A HA 2022123150300A446.78A2022683,748A150.2152,0002025630277,650A2023 2025630 Xuefeng YU 2025820 2332025630343434 2410 34 • 2025820 1. Xuefeng YuDongxu QiuHelen Huihua Mao20091131854401–42020172102017213 H2019328A2020813 2. 34 3. 202563020241231 202511 21 4. 20241231 5. 5. 202563045,038,0002024123114,687,000 6. 5 202563020241231 7. (a) 8. 8. 20256301,243,0002024630 9.– 11. 12. (a) 20252024630 (b) 202320252024630 13. 20256302024630 14. 87,145,0002024630206,788,00048,00020246305,00048,00020246305,000 20256 30154,856,00020241231158,868,000 20246302,237,000 120,998,00020241231123,981,000 15. 36242024630203,278,00020246301,070,0003,246,00020246301,070,000 6,422,00020246306,506,0002024630 202563020241231 202563020241231 16. 917,00020246302,788,00035,822,000202463062,441,000 17. 17. (a) 3,399,620,000202412313,239,508,000698,508,00020241231595,506,000104,785,0002024123189,327,0002,701,112,000202412312,644,002,000 1,469,074,000202412311,545,886,000734,557,00020241231804,635,000110,214,00020241231121,366,000734,517,00020241231741,251,000 17. (b) 19. 630885,00020241231885,000 (a)2025(b)20256308,530,0002024123114,475,000(c)202563020241231 22. 23. 2023 20233272023A2023202342020232023 202563020232023 (a) 23. 2023 (b) 202563078,420,0002024123177,865,00078,420,0002024123174,290,000 24. 24. 20256302.20%2.95%202412312.20%3.30% 20256302024123114 202563020241231 2025630621,259,00020241231244,477,000 25. 27. 28. (a) 2025630 202422 20242212 3 28. (b) (i) (ii) 28. (c) (i) (ii) (iii) 28. (c) (iv) 28. (d) 29. 29.1 20241231 2024 29. 29.2 (a) ••• 29. 29.2 (b) 29. 29.2 (b) (i)Bio–Link BiologicalPT Etana Biotechnologies Indonesia20