世界卫生组织锥虫病技术咨询小组：第八次会议报告，西班牙托莱多，2024年12月9日至12日

Report of the eighth meeting,Toledo, Spain, 9–12 December 2024 OTS8 WHO OnchocerciasisTechnical Advisory Subgroup Report of the eighth meeting,Toledo, Spain, 9–12 December 2024 WHO Onchocerciasis Technical Advisory Subgroup: report of the eighth meeting, Toledo, Spain, 9-12 December 2024 ISBN 978-92-4-011010-6 (electronic version)ISBN 978-92-4-011011-3 (print version) © World Health Organization 2025 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0IGO licence (CCBY-NC-SA3.0IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work isappropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization,products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the sameor equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with thesuggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content oraccuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the WorldIntellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules/). Suggested citation.WHO Onchocerciasis Technical Advisory Subgroup: report of the eighth meeting, Toledo, Spain, 9-12 December 2024.Geneva: World Health Organization; 2025. Licence: CCBY-NC-SA3.0IGO. Cataloguing-in-Publication (CIP) data.CIP data are available at https://iris.who.int/. Sales, rights and licensing.To purchase WHO publications, see https://www.who.int/publications/book-orders. To submit requests forcommercial use and queries on rights and licensing, see https://www.who.int/copyright. Third-party materials.If you wish to reuse material from this work that is attributed to a third party, such as tables, figures or images, it isyour responsibility to determine whether permission is needed for that reuse and to obtain permission from the copyright holder. The risk ofclaims resulting from infringement of any third-party-owned component in the work rests solely with the user. General disclaimers.The designations employed and the presentation of the material in this publication do not imply the expressionof any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of its authorities, orconcerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for whichthere may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by WHOin preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products aredistinguished by initial capital letters. All reasonable precautions have been taken by WHO to verify the information contained in this publication. However, the published materialis being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of thematerial lies with the reader. In no event shall WHO be liable for damages arising from its use. This publication contains the report of the eighth meeting of the WHO Onchocerciasis Technical Advisory Subgroup and does notnecessarily represent the decisions or policies of WHO. Contents Abbreviations Executive summaryv Introduction 1. Alternative treatment strategies for onchocerciasis and lymphatic filariasis: PICO questions and guidelinedevelopment process 2. New medicines in the pipeline: drug delivery without drug donations 5 3. Opening ceremony and panel discussion 4. Review of the iTAS manual 5. Monitoring and evaluation13 5.1 Surveillance manual and algorithms145.2 Modelling transmission dynamics to inform M&E and surveillance155.3 Post-elimination and post-verification surveillance20 6.1 USAID framework for decision-making226.2 Experience from countries assisted by The Carter Center23 7. DTAG Onchocerciasis Subgroup update on new rapid diagnostic tests 8. CDC update on ND5 and O150 qPCR for blackflies 9.Loa loa339.1 Setting the scene: what we know aboutLoa loain Africa349.2 Estimating diagnostic needs in Africa: assumptions and methodology used toforecast diagnostic needs for OV andLoa359.3Loa: test and not treat379.4 Operational research neds forLoa loa38 10. Loa loa mapping and treatment strategy References Annex 1. Agenda Annex 2. List of participants Annex 3. PICO questions for comparison of alternative intervention