四环医药：截至二零二五年六月三十日止六个月中期业绩公告

SihuanPharmaceutical Holdings Group Ltd. 0460 2410 •1,146.2949.720.7%196.5 •585.2322.881.3%262.43.0 •502.7597.315.8%94.6 •58.229.696.6%28.6 •757.3608.524.5%148.866.1%64.1%2.0% •152.8195.621.9%42.8 •264.4109.1142.3%155.3•66.268.0•102.633.4•1.11•0.991.09•3,894.3 2030License-out 10% + ®®®®NASHGLP-1 1.1 • III •1AINDA2HR+HER2-Cancer CommunicationsNature CommunicationsIIIAACR •III •GLP-1RNDAP052GLP-1R/GCGRINDSGLT-2 2. •®®®®® ®®® •®HR+HER2-CDK4/6CDK4/6 •(PPI)®PPIPPIIII •++SGLT-21®®® 3. •6,8002303834200 •2® + •PPI1,00090III •20++ 500306100®1,80060%1,000200%®500 4.3,894.32,944.00.997,524.9 • •KOL•GenesisBiosystems Inc. •GLP-1 •• 3.0585.281.3%309.5215.3% HA8060 ®®(PLLA)+®®1 ®11® ®®® ®3834®441601,000® ® PCLPLLA15®®® 5050%20 ®BYoung Club ®Sylfirm X2024CW+PW00024 Sylfirm X過2001,00018045(VIOL Co., Ltd.)100160 Sylfirm X311002375020010 ®®®Sylfirm X 1.CDK4/6 10NASH2PPI NMPA(1)HRHER2-(2)HR+HER2-HR+HER2-CDK4/6 (ET)CDK4/6i(mPFS)14.7(BIRC)mPFS17.5mPFS11 IICancer Communications20.1IIINature Communications14.7IIIAACRCDK2/4/6/9CDK4/6 (AI)HR+HER2-NDANMPAHR+HER2-HR+HER2- 3775%HR+HER2-CDK4/6130CAGR78.8%130CAGR20.2%CDK4/6 IIIPPIPPIPPI75%74.381.238.342.4NMPA1,00090PPI100 10NASH2NDA2NDA4I5IND 2.20 SGLT-2DPP-4GLP-11172426Biotech GLP-1GLP-1NDAIII(GLP-1R/GCGR)P052INDNMPA NMPA2SGLT-270(20%-30%) (IDF)1.4825.1%1.683 ++ 500103055061001,80060%1,000200%500 PIC/sGMPANVISA 10 + 502.715.8%168.41.2% 9522 102,603(33,424)(36,409)(34,534) 66,194(67,958) 66,194(67,958) 66,194(67,958) 102,603(33,424)(36,409)(34,534) (i) 1. 1.1 34 1.2 21 21 2. (a) (b) (c) 10% (23,439) (ii)30 (iii) 1,4156,783 i12,62529,75711,697–8475,17332––10,930–10,541(3,042)3,974–61 22,15960,436 (i) 4. 104,970134,377–(1,917) 5. 16.5%16.5%25%25%15% 6. 102,603,00033,424,0009,204,012,0009,280,033,000 102,603(33,424) 9,204,0129,280,033 1.11(0.36) 7. i198,374170,451 (i)(ii) (i)84,917,00078,343,000116,415,000 202,348,00085,933,000 10. 919,591841,784 (a) (i)616,380,000626,749,000(ii)56,000,00056,000,000(iii)(b)(c)2.55%4.10%2.80%4.60% 11. 6611 12. 0.991.90 0.9991,016,000177,080,000 1,146.2949.720.7%196.5 585.2322.881.3%262.43.0 502.7597.315.8%94.6 58.229.696.6%28.6 757.3608.524.5%148.866.1%64.1%2.0% 22.260.463.2%38.2 231.4213.58.4%17.9 211.9240.311.8%28.4 152.8195.621.9%42.8 19.318.35.5%1.0 264.4109.1142.3%155.3 105.0132.520.8%27.587.0107.6 156.919.2 90.748.786.2%42.0 66.268.0 102.633.4 36.434.5 3,894.33,976.42.1%82.13,257.23,522.4341.7110.6295.4343.4 4,102.614.2214.2314.075% 919.6841.830.741.583.8%16.2%91.0%9.0%21.7%20.2% 472.3417.013.3%55.3206272 1,555.21,424.29.2%131.0736.3593.924.0%142.4 1,957.62,007.52.5%49.9 899.0841.76.8%57.3 1,636.11,687.93.1%51.8 135.3 102.627.175.5 D232(4A) 10 2,767219.6311.613.82.516.036.3 C1 C3 2410 84.58116,415,0001 136,415,000 0.991.0911.097 1617 136,415,000 (www.sihuanpharm.com)(www.hkexnews.hk) 1617sihuanpharm-ecom@vistra.com