辅助生殖技术(ART)新技术领域的CAS洞察报告

NEW TECHNIQUES INASSISTEDREPRODUCTIVETECHNOLOGY EXECUTIVE SUMMARY Assisted reproductive technologies (ART) have revolutionized reproductive medicine,offering hope to millions facing fertility problems through methods like artificial inseminationto cutting-edge gene editing. While established techniques such as in vitrofertilization andintracytoplasmic sperm injection are widely used today, emerging technologies such as invitro gametogenesis, gene therapies, and stem cell-based therapies are expanding theboundaries of what is possible. ART is a rapidly advancing field, but the use of certain novel and emerging technologies inhumans is still highly experimental, tightly regulated, and surrounded by ethical and legalchallenges. Many innovations in ART are being tested only on animal models, yet somehave successfully transitioned to human applications, including preimplantation genetictesting, mitochondrial replacement therapy, time-lapse imaging, and in vitro maturation.Furthermore, artificial intelligence is transforming reproductivemedicine by enablingprecise embryo selection, optimizing clinical protocols, and predicting treatment outcomes. This report explores data from the CAS Content Collection™to outline the researchprogress in ART and identify key emerging concepts and challenges to better understandhow ART is shaping the future of reproductive healthcare. Table of Contents State of the ART: An introduction.........................................................................................................................2Current methods of assisted reproductive technology........................................................................................3Fastest-growing ART methods: AI andin vitrogametogenesis..........................................................................5AI in ART..........................................................................................................................................................5IVG in ART........................................................................................................................................................6Methods of greatest commercial interest: Stem-cell therapies and gene editing..............................................7Stem cell-based therapies...............................................................................................................................7Gene editing.....................................................................................................................................................8Additional novel methods in ART.........................................................................................................................9Genetic screening............................................................................................................................................9Mitochondrial replacement therapies...............................................................................................................9Intracytoplasmic sperm injection (ICSI).........................................................................................................10Improved embryo culture systems.................................................................................................................10Cryopreservation enhancements...................................................................................................................10Fertility preservation innovations...................................................................................................................10Non-invasive and automated technologies.....................................................................................................11Artificial wombs...............................................................................................................................................11ART research in animal models..........................................................................................................................11Challenges and ethical considerations..............................................................................................................12The future of ART...............................................................................................................................................13 State of the ART: An introduction Assisted reproductive technology (ART) encompasses a broad spectrum of medical techniques designed toaid individuals and couples in overcoming infertility challenges and enabling child conception. Infertilityaffectsapproximately 10-15% of couples worldwide, making ART a critical component of modern healthcare. ART procedures typically involve the handling of eggs, sperm, and embryos to achieve fertilization andimplantation. Techniques such as IVF and cryopreservation are now standard practices in fertility clinicsworldwide. In recent years, e