东盟一号健康研究视角下健康影响和微/纳米塑料危害的双重暴露

Economic Research Institutefor ASEAN and East Asia Policy Brief The Double Exposure of Health Impacts andMicro/Nanoplastic Hazards in the Perspectiveof ASEAN One Health Studies Key Messages: •Research on the nexus of micro/nanoplastics(MNPs)and healthis increasing in ASEAN countries,supported by both member statesand their dialogue partners. However,there remains a lack of in vivo andinvitro studies investigating thehealth impacts of MNPs. AmongstASEAN Member States, Indonesia,Malaysia, Thailand, Viet Nam, andthePhilippines have publishedthehighest number of studiesaddressing the MNPs–health dyad. Achmad Solikhin, Rahayu Susanti, Mirrah Nabighah,YasuyukiMitsuhashi, and Manami Uechi In ASEAN countries, interest in and publication of research on micro/nanoplastics(MNPs)have significantly increased,reflecting growingpoliticalwill to understand,regulate,and reduce MNP-related risks.However, the research agenda has largely focused on MNP distribution,exposure pathways, characterisation, and material properties, with limitedattention to their toxicological effects. Although there is a rise in MNP-healthresearch outputs, there has not yet been a systemic or holistic application ofthe One Health approach to assess the health risks of MNPs, nor to evaluatethe hazardous nature of MNP constituents and their impacts on humans,animals, and ecosystems. •It is time to adopt and integratetheOne Health approach intoASEANMNP studies,given thecomplex and multilayered impactsofplastic pollution on human,animal, and environmental health.Thisintegrationcanfacilitatethegeneration of more robustmultidisciplinaryevidenceontheinteractions between healthsystems and micro/nanoplastics atthe planetary level. This policy brief calls for the mainstreaming of the One Health Frameworkinto the MNP research agenda across ASEAN.One Health – a transdisciplinaryandintegrative approach–is particularly suited to addressing thecomplexity of MNP pollution by accounting for the interconnectedness ofhuman, animal, and environmental health. Integrating One Health into MNPresearch would foster collaboration across scientific disciplines and enablea more comprehensive evaluation of the implications of MNP exposure. Suchintegration would allow for robust, multidisciplinary data collection on MNPinstrumentations, exposure routes, constituent hazards, and toxicity effects. •The One Health Framework offers avaluable guide for assessing the risksassociated with MNPs by examiningtheir components, exposure routes,hazardousproperties(includingplasticpolymers,additives,heavymetals, persistent organic pollutants,antibiotics,andassociatedpathogens), and their toxicologicaleffectson humans,animals,andplants. To this end, ASEAN Member States are strongly encouraged to embed theOne Health Framework in national and regional studies on MNPs. Doingso will enhance the capacity of the region to generate actionable evidenceand support more informed, effective policy decisions on the intersection ofhealth and micro/nanoplastic pollution. •MNPs have been detected in variousorgan systems of humans, animals,and plants through multiple exposureroutes,includingentanglement,inhalation,ingestion,and dermalcontact.However,standardisedcharacterisationsforassessingMNPs and their toxic properties arenot yet fully developed. Toxicity fromMNPs may lead to a range of healtheffectssuch as oxidative stress,immuneresponses,inflammatorylesions,membranedamage,genotoxicity,cytotoxicity,anddisruptions to biological barriers. Achmad SolikhinHealthcare Policy Program Manager,ERIA Rahayu SusantiResearch Assistant, ERIA Mirrah NabighahResearch Assistant, ERIA Yasuyuki MitsuhashiSenior Health Policy Fellow, ERIA Manami UechiDirector of Healthcare Unit, ERIA Chronicles of MNPs–Health Studies in ASEAN methods,policy frameworks,and environmentalthreats posed by MNPs. However, in vitro and in vivostudies examining the direct health impacts of MNPsremainscarce.Additionally,ASEAN-based studieson MNP exposure routes, organ-level accumulation,hazard analysis, and toxicological effects are stilllimited. As of 2 May 2025, a bibliometric analysis of Scopus-indexed publications confirms a growing trend inresearch interest and published studies on the nexusof micro/nanoplastics (MNPs) and health in the ASEANregion. This increase is likely driven by the evident andescalating risks that MNPs pose to human, animal,and ecosystem health, as well as the dramatic risein plastic waste generation, facilitated by widespreadplastic consumption and population growth. TheOne Health framework–an integrated,collaborative, and transdisciplinary approach – offersa comprehensive method to address the multifacetednature of the MNPs–health nexus. This frameworkfunctionseffectively through multisectoral andinterdisciplinary engagement, supported by strongcommunication, coordination, collaboration, capacity-building,and governance mechanisms.While itsapplication to MNP–health studies is relatively newin the ASEAN