Washington, D. C. 20549________________________________________________ FORM10-K (Mark One) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year endedMarch31, 2025 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number001-38848 STERIS plc (Exact name of registrant as specified in its charter) SECURITIES REGISTERED PURSUANT TO SECTION12(B) OF THE ACT: SECURITIES REGISTERED PURSUANT TO SECTION12(G) OF THE ACT:NoneIndicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.Yesx Noo Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yeso Nox Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports); and (2) has been subject to such filingrequirements for the past 90 days.Yes x No oIndicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).Yesx No oIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growthcompany” in Rule 12b-2 of the Exchange Act. Large accelerated filerxAccelerated filer☐Non-accelerated fileroSmaller reporting company☐Emerging growth company☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any newor revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.oIndicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in thefiling reflect the correction of an error to previously issued financial statements.oIndicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).oIndicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).Yes☐No x The aggregate market value of Ordinary Shares held by non-affiliates of the registrant as of September30, 2024 was $23,874.0million.The number of Ordinary Shares outstanding as of May27, 2025:98,372,310 Table of Contents Part I Item 1BusinessIntroductionInformation Related to Business SegmentsInformation with Respect to Our Business in GeneralItem 1ARisk FactorsItem 1BUnresolved Staff CommentsItem 1CCybersecurityItem 2PropertiesItem 3Legal ProceedingsItem 4Mine Safety DisclosuresPart IIItem 5Market for Registrant's Ordinary Equity, Related Shareholder Matters and Issuer Purchases of Equity SecuritiesItem 6ReservedItem 7Management's Discussion and Analysis of Financial Condition and Results of OperationIntroductionFinancial MeasuresRevenues-DefinedGeneral Overview and Executive SummaryNon-GAAP Financial MeasuresResults of OperationsLiquidity and Capital ResourcesCapital ExpendituresMaterial Future Cash Obligations and Commercial CommitmentsSupplemental Guarantor Financial InformationCritical Accounting Estimates and AssumptionsForward-Looking StatementsItem7AQuantitative and Qualitative Disclosures About Market RiskInterest Rate RiskForeign Currency RiskCommodity RiskItem 8Financial Statements and Supplementary DataItem 9Changes in and Disagreements with Accountants on Accounting and Financial DisclosureItem9AControls and ProceduresItem 9BOther InformationItem 9CDisclosure Regarding Foreign Jurisdictions That Prevent InspectionsPart IIIItem 10Directors, Executive Officers and Corporate GovernanceItem 11Executive CompensationItem 12Security Ownership of Certain Beneficial Owners and Management and Related Stockholder MattersItem 13Certain Relationships and Related Transactions, and Director IndependenceItem 14Principal Accountant Fees and ServicesPart IVItem15Exhibits and Financial Statement ScheduleItem 16Form 10-K SummarySignatures PART I Throughout this