Ardelyx Inc 2024年度报告

2025 Annual Meeting of Stockholders Notice andProxy Statement 2024 Annual Report on Form 10-K ARDELYX, INC.400 Fifth Avenue, Suite 210, Waltham, MA 02451 NOTICE OF ANNUAL MEETING OF STOCKHOLDERSTO BE HELD ON JUNE 18, 2025 To the Stockholders of Ardelyx, Inc.: The 2025 Annual Meeting of Stockholders, or the 2025 Annual Meeting, of Ardelyx, Inc., a Delawarecorporation, or the Company, will be held on June 18, 2025 at 8:30 a.m. Eastern Time. The 2025 AnnualMeeting will be held entirely online. You will be able to attend the meeting online where you will be able tolisten to the meeting live and vote. The 2025 Annual Meeting will be held for the following purposes: (1)To elect two Class II directors to hold office until the 2028 Annual Meeting of Stockholders and untiltheir successors are elected and qualified;(2)To approve, on a non-binding, advisory basis, the compensation of our named executive officers, asdisclosed in the proxy statement accompanying this notice pursuant to the compensation disclosurerules of the Securities and Exchange Commission, or Say-on-Pay;(3)To ratify the selection, by the Audit and Compliance Committee of our board of directors, of Ernst &Young LLP as the independent registered public accounting firm of the Company for the fiscal yearending December 31, 2025;(4)To adopt the amendment (the ‘‘Equity Plan Amendment’’) to the Amended and Restated 2014 EquityIncentive Award Plan (the ‘‘Restated Plan’’) to increase the number of shares reserved for issuanceunder the Restated Plan by 10,000,000 shares; and(5)To transact such other business as may properly come before the 2025 Annual Meeting or anyadjournment or postponement thereof. The foregoing items of business are more fully described in the proxy statement accompanying this Notice ofAnnual Meeting of Stockholders. Only stockholders who owned the Company’s common stock at the close ofbusiness on Monday, April 21, 2025 may vote at the 2025 Annual Meeting or any adjournments that take place. You are cordially invited to attend the virtual 2025 Annual Meeting online via live audio-only webcast atwww.virtualshareholdermeeting.com/ARDX2025. Whether or not you plan to attend the 2025 Annual Meetingonline, please vote as soon as possible. You may vote over the internet or by a toll-free telephone number, or bymailing a complete, signed and dated proxy card or voting instruction card in the envelope provided. Please notethat any stockholder attending the 2025 Annual Meeting may vote online at the 2025 Annual Meeting, even ifthe stockholder has already voted over the internet or by phone or returned a proxy card or voting instructioncard by mail. Our board of directors recommends that you vote ‘‘FOR’’ the election of the director nominees named inProposal No. 1 of the proxy statement, ‘‘FOR’’ the approval, on a non-binding, advisory basis, of the Say-on-Payproposal as described in Proposal No. 2 of the proxy statement, ‘‘FOR’’ the ratification of the appointment ofErnst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2025as described in Proposal No. 3 of the proxy statement and ‘‘FOR’’ the approval of the Equity Plan Amendment,as described in Proposal No. 4 of the proxy statement. By Order of the Board of Directors:/s/ Elizabeth GrammerElizabeth Grammer, Esq.Chief Legal and Administrative Officer TABLE OF CONTENTS Notice of the Annual Meeting of Stockholders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1Questions and Answers Regarding the Proxy Materials and the Voting Process. . . . . . . . . . . . . . . . . .1Proposal 1 – Election of Directors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7Board and Corporate Governance Matters. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10Board Composition. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10Leadership Structure of the Board. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10Role of the Board in Risk Oversight Processes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10Meetings of the Board of Directors and Committees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11Board Committees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11Governance Policies and Principles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13Non-Employee Director Compensation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16Proposal 2 – Advisory Vote to Approve Named Executive Officer